retinal neuroprotection
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Author(s):  
Merve Sen ◽  
M.D. Al-Amin ◽  
Eva Kicková ◽  
Amir Sadeghi ◽  
Jooseppi Puranen ◽  
...  

2021 ◽  
Author(s):  
Katie L. Bales ◽  
Alicia S. Chacko ◽  
John M. Nickerson ◽  
Machelle T. Pardue ◽  
Jeffrey H. Boatright ◽  
...  

Exercise has been shown to be an effective neuroprotective intervention that preserves retinal function and structure in several animal models of retinal degeneration. However, retinal cell morphology and cell types governing exercise-induced retinal neuroprotection remain elusive. Previously, we found that the protective effects of exercise in animal models of retinal disease were accompanied by increased levels of circulating and retinal brain derived neurotrophic factor (BDNF) and required intact signal transduction with its high-affinity receptor, tropomyosin kinase B (TrkB). Studies of neurodegenerative diseases in the brain demonstrate that neurons and astrocytes express BDNF and TrkB. Additionally, astrocytes have been shown to alter their morphology in response to exercise. Here, we have investigated the role of retinal astrocytes as mediators of exercise-induced retinal neuroprotection in a light-induced retinal degeneration mouse model (LIRD). We found that treadmill exercise in both our dim (control maintenance light levels) and LIRD groups promote increased retinal astrocytic population, GFAP expression, branching and endpoints, dendritic complexity, and promotes BDNF-astrocyte interaction. In contrast, LIRD animals that were inactive had significant reductions in all measured parameters. Our findings indicate that exercise is sufficient to rescue retinal astrocyte morphology in a LIRD model maintaining branching and dendritic arborization similar to retinal astrocytes that are not undergoing degeneration. These studies provide essential information to current knowledge gaps in regards to exercise-induced neuroprotection and will additionally provide knowledge in exercise intervention optimization as a rehabilitative method.


Cells ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 633
Author(s):  
Salvatore L. Stella ◽  
Jasmine S. Geathers ◽  
Sarah R. Weber ◽  
Michael A. Grillo ◽  
Alistair J. Barber ◽  
...  

Neurodegenerative retinal diseases, such as glaucoma and diabetic retinopathy, involve a gradual loss of neurons in the retina as the disease progresses. Central nervous system neurons are not able to regenerate in mammals, therefore, an often sought after course of treatment for neuronal loss follows a neuroprotective or regenerative strategy. Neuroprotection is the process of preserving the structure and function of the neurons that have survived a harmful insult; while regenerative approaches aim to replace or rewire the neurons and synaptic connections that were lost, or induce regrowth of damaged axons or dendrites. In order to test the neuroprotective effectiveness or the regenerative capacity of a particular agent, a robust experimental model of retinal neuronal damage is essential. Zebrafish are being used more often in this type of study because their eye structure and development is well-conserved between zebrafish and mammals. Zebrafish are robust genetic tools and are relatively inexpensive to maintain. The large array of functional and behavioral tests available in zebrafish makes them an attractive model for neuroprotection studies. Some common insults used to model retinal disease and study neuroprotection in zebrafish include intense light, chemical toxicity and mechanical damage. This review covers the existing retinal neuroprotection and regeneration literature in the zebrafish and highlights their potential for future studies.


Author(s):  
Marianne Berdugo ◽  
Kimberley Delaunay ◽  
Marie-Christine Naud ◽  
Justine Guegan ◽  
Alexandre Moulin ◽  
...  

2019 ◽  
Vol 30 (3) ◽  
pp. 199-205 ◽  
Author(s):  
Thomas J. Wubben ◽  
David N. Zacks ◽  
Cagri G. Besirli

2019 ◽  
Vol 39 (12) ◽  
pp. 2313-2325 ◽  
Author(s):  
Emiel Geeraerts ◽  
Marie Claes ◽  
Eline Dekeyster ◽  
Manuel Salinas-Navarro ◽  
Lies De Groef ◽  
...  

2018 ◽  
Vol 12 ◽  
Author(s):  
Zhimin Xu ◽  
Abdelrahman Y. Fouda ◽  
Tahira Lemtalsi ◽  
Esraa Shosha ◽  
Modesto Rojas ◽  
...  

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