scholarly journals Persimmon Leaves (Diospyros kaki) Extract Protects Optic Nerve Crush-Induced Retinal Degeneration

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Hong Ryul Ahn ◽  
Kyung-A Kim ◽  
Suk Woo Kang ◽  
Joo Young Lee ◽  
Tae-Jin Kim ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Retinal Degeneration ◽  
Diospyros Kaki ◽  
Optic Nerve Crush ◽  
Nerve Crush

scholarly journals Roots of Lithospermum erythrorhizon promotes retinal cell survival in optic nerve crush-induced retinal degeneration

2021 ◽  
Vol 203 ◽  
pp. 108419
Author(s):  
Tae Kyeom Kang ◽  
Tam Thi Le ◽  
Kyung-A Kim ◽  
Young-Joo Kim ◽  
Wook-Bin Lee ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Cell Survival ◽  
Retinal Degeneration ◽  
Retinal Cell ◽  
Optic Nerve Crush ◽  
Lithospermum Erythrorhizon ◽  
Nerve Crush

scholarly journals Neuroprotective Properties of Dimethyl Fumarate Measured by Optical Coherence Tomography in Non-inflammatory Animal Models

2021 ◽  
Vol 11 ◽  
Author(s):  
Michael Dietrich ◽  
Christina Hecker ◽  
Milad Nasiri ◽  
Sogol Samsam ◽  
Andrea Issberner ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Nerve ◽  
Animal Models ◽  
Retinal Degeneration ◽  
Dimethyl Fumarate ◽  
Age Related Macular Degeneration ◽  
Optic Nerve Crush ◽  
Optical Coherence ◽  
Neuroprotective Effects ◽  
Nerve Crush

While great advances have been made in the immunomodulatory treatment of multiple sclerosis (MS), there is still an unmet need for drugs with neuroprotective potential. Dimethyl fumarate (DMF) has been suggested to exert both immunomodulatory and neuroprotective effects in MS. To investigate if DMF has neuroprotective effects independent of immunomodulation we evaluated its effects in the non-inflammatory animal models of light-induced photoreceptor loss and optic nerve crush. This might also reveal applications for DMF besides MS, such as age related macular degeneration. Retinal neurodegeneration was longitudinally assessed by in vivo retinal imaging using optical coherence tomography (OCT), and glutathione (GSH) measurements as well as histological investigations were performed to clarify the mode of action. For light-induced photoreceptor loss, one eye of C57BL/6J mice was irradiated with a LED cold light lamp while for optic nerve crush the optic nerve was clamped behind the eye bulb. The other eye served as control. GSH was measured in the optic nerve, choroid and retina and immunohistological staining of retinal microglia (Iba1) was performed. Mice were treated with 15 or 30 mg DMF/kg bodyweight or vehicle. While no protective effects were observed in optic nerve crush, in the light-induced retinal degeneration model DMF treatment significantly reduced retinal degeneration. In these mice, GSH levels in the retina and surrounding choroid were increased and histological investigations revealed less microglial activation in the outer retinal layers, suggesting both antioxidant and anti-inflammatory effects.

Different functional susceptibilities of mouse retinal ganglion cell subtypes to optic nerve crush injury

2017 ◽  
Vol 162 ◽  
pp. 97-103 ◽  
Author(s):  
Zhen Puyang ◽  
Hai-Qing Gong ◽  
Shi-Gang He ◽  
John B. Troy ◽  
Xiaorong Liu ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Crush Injury ◽  
Optic Nerve Crush ◽  
Retinal Ganglion ◽  
Nerve Crush ◽  
Nerve Crush Injury

scholarly journals Protection by an Oral Disubstituted Hydroxylamine Derivative against Loss of Retinal Ganglion Cell Differentiation following Optic Nerve Crush

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e65966 ◽  
Author(s):  
James D. Lindsey ◽  
Karen X. Duong-Polk ◽  
Yi Dai ◽  
Duy H. Nguyen ◽  
Christopher K. Leung ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Optic Nerve ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Optic Nerve Crush ◽  
Retinal Ganglion ◽  
Nerve Crush ◽  
Hydroxylamine Derivative

Inhibition of miR-21 ameliorates excessive astrocyte activation and promotes axon regeneration following optic nerve crush

2018 ◽  
Vol 137 ◽  
pp. 33-49 ◽  
Author(s):  
Hong-Jiang Li ◽  
Yuan-Bo Pan ◽  
Zhao-Liang Sun ◽  
Yi-Yu Sun ◽  
Xi-Tao Yang ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Axon Regeneration ◽  
Optic Nerve Crush ◽  
Astrocyte Activation ◽  
Nerve Crush

scholarly journals Pim-1 Expression in Rat Retina and its Changes after Optic Nerve Crush

2018 ◽  
Vol 301 (11) ◽  
pp. 1968-1976
Author(s):  
Shoumei Zhang ◽  
Dong Wang ◽  
Tingting Huang ◽  
Fang Liu ◽  
Li Shuai ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Crush ◽  
Nerve Crush ◽  
Rat Retina
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