scholarly journals Tissue Engineering: Reconfigurable Microphysiological Systems for Modeling Innervation and Multitissue Interactions (Adv. Biosys. 9/2020)

2020 ◽  
Vol 4 (9) ◽  
pp. 2070091
Author(s):  
Jonathan R. Soucy ◽  
Adam J. Bindas ◽  
Ryan Brady ◽  
Tess Torregrosa ◽  
Cailey M. Denoncourt ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Microphysiological Systems

scholarly journals Advancing cardiovascular tissue engineering

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 1045 ◽  
Author(s):  
George A. Truskey
Keyword(s):  
Tissue Engineering ◽  
Cardiac Tissue ◽  
Great Promise ◽  
Mechanical Stimuli ◽  
Cardiovascular Tissue ◽  
Microphysiological Systems ◽  
Cardiovascular Tissue Engineering ◽  
Induced Pluripotent ◽  
Improved Methods

Cardiovascular tissue engineering offers the promise of biologically based repair of injured and damaged blood vessels, valves, and cardiac tissue. Major advances in cardiovascular tissue engineering over the past few years involve improved methods to promote the establishment and differentiation of induced pluripotent stem cells (iPSCs), scaffolds from decellularized tissue that may produce more highly differentiated tissues and advance clinical translation, improved methods to promote vascularization, and novel in vitro microphysiological systems to model normal and diseased tissue function. iPSC technology holds great promise, but robust methods are needed to further promote differentiation. Differentiation can be further enhanced with chemical, electrical, or mechanical stimuli.

scholarly journals Tissue chips – innovative tools for drug development and disease modeling

Lab on a Chip ◽  
2017 ◽  
Vol 17 (18) ◽  
pp. 3026-3036 ◽  
Author(s):  
L. A. Low ◽  
D. A. Tagle
Keyword(s):  
Tissue Engineering ◽  
Drug Development ◽  
Disease Modeling ◽  
High Rate ◽  
Human Organs ◽  
Recent Advances ◽  
Microphysiological Systems ◽  
Rate Of Failure

The high rate of failure during drug development is well-known, however recent advances in tissue engineering and microfabrication have contributed to the development of microphysiological systems (MPS), or ‘organs-on-chips’ that recapitulate the function of human organs.

scholarly journals Enhancing Kidney Vasculature in Tissue Engineering—Current Trends and Approaches: A Review

Biomimetics ◽  
2021 ◽  
Vol 6 (2) ◽  
pp. 40
Author(s):  
Charlotta G. Lebedenko ◽  
Ipsita A. Banerjee
Keyword(s):  
Tissue Engineering ◽  
Large Scale ◽  
Kidney Diseases ◽  
Kidney Tissue ◽  
Small Scale ◽  
Current Trends ◽  
Large Size ◽  
Microphysiological Systems ◽  
Primary Obstacle ◽  
Kidney Stem Cells

Chronic kidney diseases are a leading cause of fatalities around the world. As the most sought-after organ for transplantation, the kidney is of immense importance in the field of tissue engineering. The primary obstacle to the development of clinically relevant tissue engineered kidneys is precise vascularization due to the organ’s large size and complexity. Current attempts at whole-kidney tissue engineering include the repopulation of decellularized kidney extracellular matrices or vascular corrosion casts, but these approaches do not eliminate the need for a donor organ. Stem cell-based approaches, such as kidney organoids vascularized in microphysiological systems, aim to construct a kidney without the need for organ donation. These organ-on-a-chip models show complex, functioning kidney structures, albeit at a small scale. Novel methodologies for developing engineered scaffolds will allow for improved differentiation of kidney stem cells and organoids into larger kidney grafts with clinical applications. While currently, kidney tissue engineering remains mostly limited to individual renal structures or small organoids, further developments in vascularization techniques, with technologies such as organoids in microfluidic systems, could potentially open doors for a large-scale growth of whole engineered kidneys for transplantation.

Decellularized bone extracellular matrix in skeletal tissue engineering

2020 ◽  
Vol 48 (3) ◽  
pp. 755-764
Author(s):  
Benjamin B. Rothrauff ◽  
Rocky S. Tuan
Keyword(s):  
Tissue Engineering ◽  
Bone Regeneration ◽  
Tissue Regeneration ◽  
Animal Studies ◽  
Tumor Resection ◽  
Regenerative Capacity ◽  
Skeletal Tissue ◽  
Large Bone

Bone possesses an intrinsic regenerative capacity, which can be compromised by aging, disease, trauma, and iatrogenesis (e.g. tumor resection, pharmacological). At present, autografts and allografts are the principal biological treatments available to replace large bone segments, but both entail several limitations that reduce wider use and consistent success. The use of decellularized extracellular matrices (ECM), often derived from xenogeneic sources, has been shown to favorably influence the immune response to injury and promote site-appropriate tissue regeneration. Decellularized bone ECM (dbECM), utilized in several forms — whole organ, particles, hydrogels — has shown promise in both in vitro and in vivo animal studies to promote osteogenic differentiation of stem/progenitor cells and enhance bone regeneration. However, dbECM has yet to be investigated in clinical studies, which are needed to determine the relative efficacy of this emerging biomaterial as compared with established treatments. This mini-review highlights the recent exploration of dbECM as a biomaterial for skeletal tissue engineering and considers modifications on its future use to more consistently promote bone regeneration.

Sign in / Sign up

Export Citation Format

Share Document