Direct deposited porous scaffolds of calcium phosphate cement with alginate for drug delivery and bone tissue engineering

2011 ◽  
Vol 7 (8) ◽  
pp. 3178-3186 ◽  
Author(s):  
Gil-Su Lee ◽  
Jeong-Hui Park ◽  
Ueon Sang Shin ◽  
Hae-Won Kim
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Calcium Phosphate Cement ◽  
Porous Scaffolds

The Application of Energetic SHS Reactions in the Synthesis of Multi-functional Bone Tissue Engineering and Drug Delivery Systems

2005 ◽  
Vol 896 ◽  
Author(s):  
Reed Ayers ◽  
Doug Burkes ◽  
Guglielmo Gottoli ◽  
H.C. Yi ◽  
Jaque Guigné ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Combustion Synthesis ◽  
Bone Tissue ◽  
Drug Delivery Systems ◽  
Exothermic Reaction ◽  
Functional Materials ◽  
Delivery Systems

AbstractThe term combustion synthesis, or self-propagating high temperature synthesis (SHS), refers to an exothermic chemical reaction process that utilizes the heat generated by the exothermic reaction to ignite and sustain a propagating combustion wave through the reactants to produce the desired product(s). The products of combustion synthesis normally are extremely porous: typically 50 percent of theoretical densityAdvantages of combustion synthesis over traditional processing routes, e.g., sintering, in the production of advanced materials such as ceramics, intermetallic compounds and composites include process economics, simplicity of operation, and low energy requirements. However, the high exothermicity and rapid combustion propagation rates necessitate a high degree of control of these reactions.One research area being conducted in the Institute for Space Resources (ISR) at the Colorado School of Mines (CSM) is the application of combustion synthesis (SHS) to synthesize advanced, engineered porous multiphase/heterogeneous calcium phosphate (HCaP), NiTi, NiTi-TiC, TiB-Ti, TiC-Ti for bone tissue engineering and drug delivery systems. Such material systems require a complex combination of properties that can be truly classified as multi-functional materials. The range of properties includes: an overall porosity of 40-60% with a pore size of 200-500 μm; mechanical properties (compression strength and Young’s modulus) that match those of natural bone to avoid ‘stress shielding’; and a surface chemistry that is capable of facilitating bone growth and mineralization.The paper will discuss the synthesis of porous multiphase/heterogeneous calcium phosphate (HCaP), NiTi, NiTi-TiC, TiB-Ti, TiC-Ti for bone tissue engineering and drug delivery systems.

Preparation and characterization of calcium phosphate/pectin scaffolds for bone tissue engineering

RSC Advances ◽  
2016 ◽  
Vol 6 (67) ◽  
pp. 62071-62082 ◽  
Author(s):  
Lisheng Zhao ◽  
Junjie Li ◽  
Liang Zhang ◽  
Yu Wang ◽  
Jiexin Wang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Compressive Strength ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Clinical Application ◽  
Calcium Phosphate Cement ◽  
Bone Defects

A calcium phosphate cement (CPC) scaffold has been used to repair bone defects, but its low compressive strength and poor osteogenesis greatly hinder its clinical application.

scholarly journals Incorporation of fast dissolving glucose porogens into an injectable calcium phosphate cement for bone tissue engineering

2017 ◽  
Vol 50 ◽  
pp. 68-77 ◽  
Author(s):  
Brandon T. Smith ◽  
Marco Santoro ◽  
Eline C. Grosfeld ◽  
Sarita R. Shah ◽  
Jeroen J.J.P. van den Beucken ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Calcium Phosphate Cement

APPLICATIONS OF CALCIUM PHOSPHATE NANOPARTICLES IN POROUS HARD TISSUE ENGINEERING SCAFFOLDS

NANO ◽  
2012 ◽  
Vol 07 (04) ◽  
pp. 1230004 ◽  
Author(s):  
ZHE WANG ◽  
ZHURONG TANG ◽  
FANGZHU QING ◽  
YOULIANG HONG ◽  
XINGDONG ZHANG
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Three Dimensional ◽  
Porous Scaffolds ◽  
Tissue Engineering Scaffolds ◽  
Important Approach ◽  
Calcium Phosphate Nanoparticles ◽  
Hard Tissue Engineering

To repair bone defects, an important approach is to fabricate tissue engineering scaffolds as substitutions to replace auto-/allologous bones. Currently, processing a biomaterial into three-dimensional porous scaffolds and incorporating the calcium phosphate (Ca–P) nanoparticles into scaffolds profile two main characteristics of bone tissue engineering scaffolds. Based on this fact, in this paper we describe the design principles of the Ca–P nanoparticle-based and porous bone tissue engineering scaffolds. Then we summarize a variety of the Ca–P nanoparticle-based scaffolds, including discussion of the integration of the Ca–P nanoparticles with ceramics and polymers, followed by introduction of safety of the Ca–P nanoparticles in scaffolds.

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