Preparation and characterization of calcium phosphate/pectin scaffolds for bone tissue engineering

RSC Advances ◽  
2016 ◽  
Vol 6 (67) ◽  
pp. 62071-62082 ◽  
Author(s):  
Lisheng Zhao ◽  
Junjie Li ◽  
Liang Zhang ◽  
Yu Wang ◽  
Jiexin Wang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Compressive Strength ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Clinical Application ◽  
Calcium Phosphate Cement ◽  
Bone Defects

A calcium phosphate cement (CPC) scaffold has been used to repair bone defects, but its low compressive strength and poor osteogenesis greatly hinder its clinical application.

Microstructure and Properties of A Calcium Phosphate Cement Tissue Engineering Scaffold Modified with Collagen and Chitosan

2007 ◽  
Vol 330-332 ◽  
pp. 983-986
Author(s):  
Xiu Peng Wang ◽  
Jian Dong Ye ◽  
Ling Chen ◽  
Ying Jun Wang
Keyword(s):  
Tissue Engineering ◽  
Cell Culture ◽  
Compressive Strength ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Calcium Phosphate Cement ◽  
Tissue Engineering Scaffold ◽  
Promising Material ◽  
Microstructure And Properties

In this study, an ACP-DCPD based Calcium phosphate cement (CPC) scaffold with a porosity of 88% was prepared by using Na3PO4 as a poregen and then modified by collagen and chitosan. The results showed that collagen and chitosan obviously increased the compressive strength. Cell culture showed that the cell can migrate, attach, proliferate and differentiate on the surface of the materials and the pores walls. This CPC scaffold modified with collagen or chitosan was a promising material to be used in bone tissue engineering.

Fully Interconnected Globular Porous Biphasic Calcium Phosphate Ceramic Scaffold Facilitates Osteogenic Repair

2007 ◽  
Vol 361-363 ◽  
pp. 119-122 ◽  
Author(s):  
J.H. Lim ◽  
J.H. Park ◽  
Eui Kyun Park ◽  
Hae Jung Kim ◽  
Il Kyu Park ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bone Substitute ◽  
Biphasic Calcium Phosphate ◽  
Bone Defects ◽  
Calcium Phosphate Ceramic ◽  
Ceramic Scaffold ◽  
Porous Biphasic Calcium Phosphate

An appropriate scaffold, which provides structural support for transplanted cells and acts as a vehicle for the delivery of biologically active molecules, is critical for tissue engineering. We developed a fully interconnected globular porous biphasic calcium phosphate ceramic scaffold by adopting a foaming method, and evaluated its efficiency as a bone substitute and a scaffold for bone tissue engineering by in vitro and in vivo biocompatible analysis and its osteogenic healing capacity in rat tibial bone defects. They have spherical pores averaging 400um in diameter and interconnecting interpores averaging 70um in diameter with average 85% porosity. They elicited no cytotoxicity and noxious effect on cellular proliferation and osteoblastic differentiation during the cell-scaffold construct formation. Also the bone defects grafted with fully interconnected globular porous biphasic calcium phosphate ceramic blocks revealed excellent bone healing within 3 weeks. These findings suggest that the fully interconnected porous biphasic calcium phosphate scaffold formed by the foaming method can be a promising bone substitute and a scaffold for bone tissue engineering.

scholarly journals Incorporation of fast dissolving glucose porogens into an injectable calcium phosphate cement for bone tissue engineering

2017 ◽  
Vol 50 ◽  
pp. 68-77 ◽  
Author(s):  
Brandon T. Smith ◽  
Marco Santoro ◽  
Eline C. Grosfeld ◽  
Sarita R. Shah ◽  
Jeroen J.J.P. van den Beucken ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Calcium Phosphate Cement

Preparation and characterization of four different compositions of calcium phosphate scaffolds for bone tissue engineering

2011 ◽  
Vol 62 (5) ◽  
pp. 526-534 ◽  
Author(s):  
Shih-Ching Wu ◽  
Hsueh-Chuan Hsu ◽  
Shih-Kuang Hsu ◽  
Wei-Hsin Wang ◽  
Wen-Fu Ho
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Bone Tissue
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