scholarly journals Flexural characterization of cell encapsulated PEGDA hydrogels with applications for tissue engineered heart valves

2011 ◽  
Vol 7 (6) ◽  
pp. 2467-2476 ◽  
Author(s):  
Christopher A. Durst ◽  
Michael P. Cuchiara ◽  
Elizabeth G. Mansfield ◽  
Jennifer L. West ◽  
K. Jane Grande-Allen
Keyword(s):  
Heart Valves ◽  
Tissue Engineered Heart Valves

Inverse Mechanical Characterization of Tissue Engineered Heart Valves

2008 ◽  
Author(s):  
Martijn A. J. Cox ◽  
Jeroen Kortsmit ◽  
Niels J. B. Driessen ◽  
Carlijn V. C. Bouten ◽  
Frank P. T. Baaijens
Keyword(s):  
Heart Valves ◽  
Soft Tissues ◽  
Mechanical Characterization ◽  
Tensile Tests ◽  
Material Behavior ◽  
Uniaxial Tensile ◽  
Mechanical Conditioning ◽  
Indentation Tests ◽  
Tissue Engineered Heart Valves

Over the last few years, research interest in tissue engineering as an alternative for current treatment and replacement strategies for cardiovascular and heart valve diseases has significantly increased. In vitro mechanical conditioning is an essential tool for engineering strong implantable tissues [1]. Detailed knowledge of the mechanical properties of the native tissue as well as the properties of the developing engineered constructs is vital for a better understanding and control of the mechanical conditioning process. The nonlinear and anisotropic behavior of soft tissues puts high demands on their mechanical characterization. Current standards in mechanical testing of soft tissues include (multiaxial) tensile testing and indentation tests. Uniaxial tensile tests do not provide sufficient information for characterizing the full anisotropic material behavior, while biaxial tensile tests are difficult to perform, and boundary effects limit the test region to a small central portion of the tissue. In addition, characterization of the local tissue properties from a tensile test is non-trivial. Indentation tests may be used to overcome some of these limitations. Indentation tests are easy to perform and when indenter size is small relative to the tissue dimensions, local characterization is possible. We have demonstrated that by recording deformation gradients and indentation force during a spherical indentation test the anisotropic mechanical behavior of engineered cardiovascular constructs can be characterized [2]. In the current study this combined numerical-experimental approach is used on Tissue Engineered Heart Valves (TEHV).

scholarly journals Characterization of Dermal Fibroblasts as a Cell Source for Pediatric Tissue Engineered Heart Valves

2014 ◽  
Vol 1 (2) ◽  
pp. 146-162 ◽  
Author(s):  
Monica Fahrenholtz ◽  
Huiwen Liu ◽  
Debra Kearney ◽  
Lalita Wadhwa ◽  
Charles Fraser ◽  
...  
Keyword(s):  
Heart Valves ◽  
Dermal Fibroblasts ◽  
Cell Source ◽  
A Cell ◽  
Tissue Engineered Heart Valves

In Vivo Remodeling and Structural Characterization of Fibrin-Based Tissue-Engineered Heart Valves in the Adult Sheep Model

2009 ◽  
Vol 15 (10) ◽  
pp. 2965-2976 ◽  
Author(s):  
Thomas C. Flanagan ◽  
Jörg S. Sachweh ◽  
Julia Frese ◽  
Heike Schnöring ◽  
Nina Gronloh ◽  
...  
Keyword(s):  
Structural Characterization ◽  
Heart Valves ◽  
Sheep Model ◽  
Adult Sheep ◽  
Tissue Engineered Heart Valves

In vivo repopulation of tissue engineered heart valves

2010 ◽  
Vol 58 (S 01) ◽  
Author(s):  
PM Dohmen ◽  
A Lembcke ◽  
S Holinski ◽  
JP Braun ◽  
W Konertz
Keyword(s):  
Heart Valves ◽  
Tissue Engineered Heart Valves

scholarly journals Computational modelling to reduce outcome variability in tissue-engineered heart valves

2021 ◽  
Author(s):  
Valery L Visser ◽  
Polina Zaytseva ◽  
Sarah E Motta ◽  
Sandra Loerakker ◽  
Simon P Hoerstrup ◽  
...  
Keyword(s):  
Heart Valves ◽  
Computational Modelling ◽  
Tissue Engineered Heart Valves

In-vitro characterization of flow through mechanical heart valves

2006 ◽  
Vol 39 ◽  
pp. S306 ◽  
Author(s):  
L.P. Dasi ◽  
H. Simon ◽  
L. Ge ◽  
F. Sotiropoulos ◽  
A. Yoganathan
Keyword(s):  
Heart Valves ◽  
Mechanical Heart Valves ◽  
In Vitro Characterization ◽  
Flow Through

The use of polymer based scaffolds in tissue-engineered heart valves

2006 ◽  
Vol 21 (2) ◽  
pp. 193-199 ◽  
Author(s):  
Peter Fong ◽  
Toshiharu Shin'oka ◽  
Reynold I. Lopez-Soler ◽  
Christopher Breuer
Keyword(s):  
Heart Valves ◽  
Tissue Engineered Heart Valves

Large Displacement Flexural Properties of Tissue Engineered Heart Valve Scaffolds

2000 ◽  
Author(s):  
Michael S. Sacks ◽  
Sanjay Kaushal ◽  
John E. Mayer
Keyword(s):  
Heart Valve ◽  
Heart Valves ◽  
Critical Test ◽  
Bioprosthetic Heart Valves ◽  
Property Evaluation ◽  
Fundamental Information ◽  
Tissue Engineered Heart Valve ◽  
Valve Prostheses ◽  
Tissue Engineered Heart Valves

Abstract The need for improved heart valve prostheses is especially critical in pediatric applications, where growth and remodeling are essential. Tissue engineered heart valves (TEHV) have functioned in the pulmonary circulation of growing lambs for up to four months [1], and thus can potentially overcome limitations of current bioprosthetic heart valves. Despite these promising results, significant questions remain. In particular, the role of scaffold mechanical properties in optimal extra-cellular matrix development, as well as TEHV durability, are largely unexplored. We have previously demonstrated flexure testing as a sensitive and critical test for BHV tissue mechanical property evaluation [2]. The following study was conducted to determine the feasibility of using this technique to provide fundamental information required for optimizing TEHV scaffold designs.

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