Multiplexed label-free electrochemical immunosensor for breast cancer precision medicine

2020 ◽  
Vol 1130 ◽  
pp. 60-71
Author(s):  
Suparat Cotchim ◽  
Panote Thavarungkul ◽  
Proespichaya Kanatharana ◽  
Warakorn Limbut
Keyword(s):  
Breast Cancer ◽  
Precision Medicine ◽  
Electrochemical Immunosensor ◽  
Label Free

A Label-free Multiplex Electrochemical Biosensor for Detection of Three Breast Cancer Biomarker Proteins Employing Dye/Metal Ions-loaded and Antibodies-Conjugated Polyethyleneimine-Gold Nanoparticles

2021 ◽  
Author(s):  
Kulrisa Kuntamung ◽  
Jaroon Jakmunee ◽  
Kontad Ounnunkad
Keyword(s):  
Breast Cancer ◽  
Electrochemical Biosensor ◽  
Simultaneous Detection ◽  
Growth Factor Receptor ◽  
Cancer Biomarkers ◽  
Electrochemical Immunosensor ◽  
Label Free ◽  
Cancer Antigen ◽  
Breast Cancer Biomarkers ◽  
Epidermal Growth

A new electrochemical immunosensor is developed for the label-free simultaneous detection of mucin1 (MUC1), cancer antigen 15-3 (CA15-3), and human epidermal growth factor receptor 2 (HER2) early breast cancer biomarkers....

New label-free ultrasensitive electrochemical immunosensor-based Au/MoS2/rGO nanocomposites for CA 27-29 breast cancer antigen detection

2018 ◽  
Vol 42 (13) ◽  
pp. 11046-11053 ◽  
Author(s):  
Nawal A. Alarfaj ◽  
Maha F. El-Tohamy ◽  
Hesham Oraby
Keyword(s):  
Breast Cancer ◽  
Early Diagnosis ◽  
Electrochemical Immunosensor ◽  
Antigen Detection ◽  
Label Free ◽  
Cancer Antigen

Early diagnosis and clinical treatments of breast cancer provide a highly successful chance for patients to survive.

An electrochemical immunosensor for detection of a breast cancer biomarker based on antiHER2–iron oxide nanoparticle bioconjugates

The Analyst ◽  
2014 ◽  
Vol 139 (11) ◽  
pp. 2858-2866 ◽  
Author(s):  
Mahdi Emami ◽  
Mojtaba Shamsipur ◽  
Reza Saber ◽  
Rasoul Irajirad
Keyword(s):  
Breast Cancer ◽  
Iron Oxide ◽  
Cancer Biomarker ◽  
Electrochemical Immunosensor ◽  
Iron Oxide Nanoparticle ◽  
Label Free ◽  
Highly Sensitive ◽  
Oxide Nanoparticle

This paper presents a facile and highly sensitive label free electrochemical immunosensor for detection of a breast cancer biomarker using antiHER2–Fe3O4 NP bioconjugates.

Electrochemical Immunosensors Based on Nanostructured Materials for Sensing of Prostate-Specific Antigen: A Review

2020 ◽  
Vol 28 ◽  
Author(s):  
Hayati Filik ◽  
Asiye Aslıhan Avan ◽  
Mustafa Özyürek
Keyword(s):  
Prostate Specific Antigen ◽  
Nanostructured Materials ◽  
Specific Antigen ◽  
Electrochemical Immunosensor ◽  
Label Free ◽  
Electrochemical Immunosensors ◽  
Metal Metal ◽  
Different Types ◽  
Sandwich Type ◽  
Carbon Based Nanomaterials

: The prostate-specific antigen (PSA) has been considered a crucial serological marker for distinguishing prostate based cancer. This surveys recent progress in the construction of nanomaterial-based electrochemical immunosensors for a PSA. This review (from 2015 to 2020) reports the latest progress in PSA sensing based on the employ of different types of nanostructured materials. The most popular used nanostructured materials are metal, metal oxide, carbon-based nanomaterials, and their hybrid architectures utilized for distinct amplification protocols. In this review, the electrochemical immunosensors for prostate-specific antigen sensing are classified into three categories such as sandwich type@labeled, label free@nonlabeled and aptamer-based electrochemical immunosensor.

scholarly journals Recommendations for streamlining precision medicine in breast cancer care in Latin America

2021 ◽  
Author(s):  
Isabel Alvarado‐Cabrero ◽  
Franco Doimi ◽  
Virginia Ortega ◽  
Jurema Telles Oliveira Lima ◽  
Rubén Torres ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Latin America ◽  
Precision Medicine ◽  
Cancer Care ◽  
Breast Cancer Care

scholarly journals Ultrasensitive and label free electrochemical immunosensor for detection of ROR1 as an oncofetal biomarker using gold nanoparticles assisted LDH/rGO nanocomposite

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Rozita Abolhasan ◽  
Balal Khalilzadeh ◽  
Hadi Yousefi ◽  
Sahar Samemaleki ◽  
Forough Chakari-Khiavi ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Flexible Structures ◽  
Modified Electrodes ◽  
Electrochemical Immunosensor ◽  
Lymphocytic Leukemia ◽  
Orphan Receptor ◽  
Detection Sensitivity ◽  
Label Free ◽  
Serum Samples ◽  
Limit Of Quantification

AbstractIn the present article, we developed a highly sensitive label-free electrochemical immunosensor based on NiFe-layered double hydroxides (LDH)/reduced graphene oxide (rGO)/gold nanoparticles modified glassy carbon electrode for the determination of receptor tyrosine kinase-like orphan receptor (ROR)-1. In this electrochemical immunoassay platform, NiFe-LDH/rGO was used due to great electron mobility, high specific surface area and flexible structures, while Au nanoparticles were prepared and coated on the modified electrodes to improve the detection sensitivity and ROR1 antibody immobilizing (ROR1Ab). The modification procedure was approved by using cyclic voltammetry and differential pulse voltammetry based on the response of peak current to the step by step modifications. Under optimum conditions, the experimental results showed that the immunosensor revealed a sensitive response to ROR1 in the range of 0.01–1 pg mL−1, and with a lower limit of quantification of 10 attogram/mL (10 ag mL−1). Furthermore, the designed immunosensor was applied for the analysis of ROR1 in several serum samples of chronic lymphocytic leukemia suffering patients with acceptable results, and it also exhibited good selectivity, reproducibility and stability.

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