An electrochemical immunosensor for detection of a breast cancer biomarker based on antiHER2–iron oxide nanoparticle bioconjugates

The Analyst ◽  
2014 ◽  
Vol 139 (11) ◽  
pp. 2858-2866 ◽  
Author(s):  
Mahdi Emami ◽  
Mojtaba Shamsipur ◽  
Reza Saber ◽  
Rasoul Irajirad
Keyword(s):  
Breast Cancer ◽  
Iron Oxide ◽  
Cancer Biomarker ◽  
Electrochemical Immunosensor ◽  
Iron Oxide Nanoparticle ◽  
Label Free ◽  
Highly Sensitive ◽  
Oxide Nanoparticle

This paper presents a facile and highly sensitive label free electrochemical immunosensor for detection of a breast cancer biomarker using antiHER2–Fe3O4 NP bioconjugates.

scholarly journals Imaging breast cancer using a dual-ligand nanochain particle

2018 ◽  
Author(s):  
Gil Covarrubias ◽  
Anthony Cha ◽  
Abdelrahman Rahmy ◽  
Morgan Lorkowski ◽  
Vindya Perera ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Iron Oxide ◽  
Linear Chain ◽  
Breast Tumors ◽  
Iron Oxide Nanoparticle ◽  
Vascular Targeting ◽  
Temporal Expression ◽  
Tumor Endothelium ◽  
Oxide Nanoparticle

ABSTRACTNanoparticles often only exploit the upregulation of a receptor on cancer cells to enhance intratumoral deposition of therapeutic and imaging agents. However, a single targeting moiety assumes that a tumor is homogenous and static. Tumoral microenvironments are both heterogenous and dynamic, often displaying variable spatial and temporal expression of targetable receptors throughout disease progression. Here, we evaluated the in vivo performance of an iron oxide nanoparticle in terms of targeting and imaging of orthotropic mouse models of aggressive breast tumors. The nanoparticle, a multi-component nanochain, was comprised of 3-5 iron oxide nanoparticles chemically linked in a linear chain. The nanoparticle’s surface was decorated with two types of ligands each targeting two different upregulated biomarkers on the tumor endothelium, P-selectin and fibronectin. The nanochain exhibited improved tumor deposition not only through vascular targeting but also through its elongated structure. A single-ligand nanochain exhibited a ∼2.5-fold higher intratumoral deposition than a spherical nanoparticle variant. Furthermore, the dual-ligand nanochain exhibited higher consistency in generating detectable MR signals compared to a single-ligand nanochain. Using a 7T MRI, the dual-ligand nanochains exhibited highly detectable MR signal within 3h after injection in two different animal models of breast cancer.

Iron oxide nanoparticle targeted chemo-immunotherapy for triple negative breast cancer

2021 ◽  
Author(s):  
Qingxin Mu ◽  
Guanyou Lin ◽  
Mike Jeon ◽  
Hui Wang ◽  
Fei-Chien Chang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Iron Oxide ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Iron Oxide Nanoparticle ◽  
Oxide Nanoparticle

scholarly journals Reversible magnetism switching of iron oxide nanoparticle dispersions by controlled agglomeration

2021 ◽  
Author(s):  
Stephan Müssig ◽  
Björn Kuttich ◽  
Florian Fidler ◽  
Daniel Haddad ◽  
Susanne Wintzheimer ◽  
...  
Keyword(s):  
Magnetic Properties ◽  
Iron Oxide ◽  
Light Scattering ◽  
Superparamagnetic Iron Oxide ◽  
Iron Oxide Nanoparticle ◽  
Oxide Nanoparticles ◽  
X Ray ◽  
X Ray Scattering ◽  
Nanoparticle Dispersions ◽  
Oxide Nanoparticle

The controlled agglomeration of superparamagnetic iron oxide nanoparticles (SPIONs) was used to rapidly switch their magnetic properties. Small-angle X-ray scattering (SAXS) and dynamic light scattering showed that tailored iron oxide...

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