Nano composite system based on coumarin derivative–titanium dioxide nanoparticles and ionic liquid: Determination of levodopa and carbidopa in human serum and pharmaceutical formulations

2013 ◽  
Vol 798 ◽  
pp. 25-32 ◽  
Author(s):  
Mohammad Mazloum-Ardakani ◽  
Alireza Khoshroo
Keyword(s):  
Ionic Liquid ◽  
Titanium Dioxide ◽  
Human Serum ◽  
Composite System ◽  
Titanium Dioxide Nanoparticles ◽  
Pharmaceutical Formulations ◽  
Coumarin Derivative ◽  
Nano Composite

A highly selective colorimetric assay for the determination of creatinine in biological samples using gluconic acid capped silver nanoparticles after ionic liquid based dispersive liquid phase microextraction

2021 ◽  
pp. 1-8
Author(s):  
Susan Sadeghi ◽  
Mohadeseh Hosseinpour-Zaryabi
Keyword(s):  
Silver Nanoparticles ◽  
Ionic Liquid ◽  
Liquid Phase ◽  
Human Serum ◽  
Gluconic Acid ◽  
Ag Nps ◽  
Liquid Phase Microextraction ◽  
Relative Standard ◽  
Serum And Urine

A dispersive liquid-phase microextraction method combined with UV–vis spectrophotometry was utilized to highly selective determination of creatinine in human serum and urine samples. To overcome the interferences in complex matrices, creatinine reacted with 1,4-naphthoquinone-2- potassium sulfonate reagent to produce a red coloured product that could be extracted into a small volume of 1-hexyl-3-methylimidazolium hexafluorophosphate ([HMIM]PF6) ionic liquid solvent. To increase the sensitivity of the assay, gluconic acid capped silver nanoparticles (Ag NPs) were used. On addition of Ag NPs to the red coloured extracted product, the solution turned to blue accompanied with a red shift in wavelength around 620 nm that could be detected by the naked eye. The effective variables on the determination of creatinine such as concentration of the reagent, amount of formic and hydrochloric acids, type and volume of the extractant, and concentration of Ag NPs were investigated. Under the optimal conditions, the calibration plot was bimodal with linear ranges from 0.1 to 1.5 µg mL−1 and 1.5 to 105 µg mL−1 creatinine with a limit of detection 0.1 µg mL−1. The relative standard deviation for five measurements at 35 µg mL−1 concentration level was 3.8%. The newly developed assay was used for the determination of creatinine in human serum and urine specimens with satisfactory results.

Effective and Facile Determination of Vitamin B6 in Human Serum with CuO Nanoparticles/Ionic Liquid Crystal Carbon Based Sensor

2017 ◽  
Vol 164 (13) ◽  
pp. B730-B738 ◽  
Author(s):  
Nada F. Atta ◽  
Ahmed Galal ◽  
Ekram H. El-Ads ◽  
Asmaa R. M. El-Gohary
Keyword(s):  
Ionic Liquid ◽  
Liquid Crystal ◽  
Human Serum ◽  
Vitamin B6 ◽  
Cuo Nanoparticles ◽  
Carbon Based

Nano composite system based on fullerene-functionalized carbon nanotubes for simultaneous determination of levodopa and acetaminophen

Measurement ◽  
2016 ◽  
Vol 91 ◽  
pp. 162-167 ◽  
Author(s):  
Mohammad Mazloum-Ardakani ◽  
Seyyed Hamid Ahmadi ◽  
Zohal Safaei Mahmoudabadi ◽  
Alireza Khoshroo
Keyword(s):  
Carbon Nanotubes ◽  
Simultaneous Determination ◽  
Composite System ◽  
Functionalized Carbon Nanotubes ◽  
Nano Composite

scholarly journals Sensitive Determination of Terazosin in Pharmaceutical Formulations and Biological Samples by Ionic-Liquid Microextraction Prior to Spectrofluorimetry

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Mohsen Zeeb ◽  
Mahdi Sadeghi
Keyword(s):  
Ionic Liquid ◽  
Ionic Strength ◽  
Biological Samples ◽  
Limit Of Detection ◽  
Pharmaceutical Formulations ◽  
Experimental Conditions ◽  
Relative Standard ◽  
Common Ion ◽  
Liquid Microextraction

An efficient and environmentally friendly sample preparation method based on the application of hydrophobic 1-Hexylpyridinium hexafluorophosphate [Hpy][PF6] ionic liquid (IL) as a microextraction solvent was proposed to preconcentrate terazosin. The performance of the microextraction method was improved by introducing a common ion of pyridinium IL into the sample solution. Due to the presence of the common ion, the solubility of IL significantly decreased. As a result, the phase separation successfully occurred even at high ionic strength, and the volume of the settled IL-phase was not influenced by variations in the ionic strength (up to 30% w/v). After preconcentration step, the enriched phase was introduced to the spectrofluorimeter for the determination of terazosin. The obtained results revealed that this system did not suffer from the limitations of that in conventional ionic-liquid microextraction. Under optimum experimental conditions, the proposed method provided a limit of detection (LOD) of 0.027 μg L−1and a relative standard deviation (R.S.D.) of 2.4%. The present method was successfully applied to terazosin determination in actual pharmaceutical formulations and biological samples. Considering the large variety of ionic liquids, the proposed microextraction method earns many merits, and will present a wide application in the future.

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