Manufacturing of a novel double-function ssDNA aptamer for sensitive diagnosis and efficient neutralization of SEA

2018 ◽  
Vol 548 ◽  
pp. 69-77 ◽  
Author(s):  
Hamid Sedighian ◽  
Raheleh Halabian ◽  
Jafar Amani ◽  
Mohammad Heiat ◽  
Ramezan Ali Taheri ◽  
...  
Keyword(s):  
Double Function ◽  
Ssdna Aptamer

Rapid and Accurate Quantification of Paramylon Produced from Euglena gracilis Using an ssDNA Aptamer

2019 ◽  
Vol 68 (1) ◽  
pp. 402-408 ◽  
Author(s):  
Jee Young Kim ◽  
Jeong-Joo Oh ◽  
Da Hee Kim ◽  
Jaewon Park ◽  
Hyun Soo Kim ◽  
...  
Keyword(s):  
Euglena Gracilis ◽  
Ssdna Aptamer ◽  
Accurate Quantification

scholarly journals Contingent associations and the double-function, verbal-discrimination task

1975 ◽  
Vol 3 (3) ◽  
pp. 311-314 ◽  
Author(s):  
Benton J. Underwood ◽  
Charles S. Reichardt
Keyword(s):  
Discrimination Task ◽  
Verbal Discrimination ◽  
Double Function

scholarly journals The Role of Prokineticin 2 in Oxidative Stress and in Neuropathological Processes

2021 ◽  
Vol 12 ◽  
Author(s):  
Roberta Lattanzi ◽  
Cinzia Severini ◽  
Daniela Maftei ◽  
Luciano Saso ◽  
Aldo Badiani
Keyword(s):  
Pain Perception ◽  
G Protein Coupled Receptors ◽  
Cellular Processes ◽  
Prokineticin 2 ◽  
Physiological Processes ◽  
Pathological Conditions ◽  
Double Function ◽  
The Central Nervous System ◽  
G Protein Coupled

The prokineticin (PK) family, prokineticin 1 and Bv8/prokineticin 2 (PROK2), initially discovered as regulators of gastrointestinal motility, interacts with two G protein-coupled receptors, PKR1 and PKR2, regulating important biological functions such as circadian rhythms, metabolism, angiogenesis, neurogenesis, muscle contractility, hematopoiesis, immune response, reproduction and pain perception. PROK2 and PK receptors, in particular PKR2, are widespread distributed in the central nervous system, in both neurons and glial cells. The PROK2 expression levels can be increased by a series of pathological insults, such as hypoxia, reactive oxygen species, beta amyloid and excitotoxic glutamate. This suggests that the PK system, participating in different cellular processes that cause neuronal death, can be a key mediator in neurological/neurodegenerative diseases. While many PROK2/PKRs effects in physiological processes have been documented, their role in neuropathological conditions is not fully clarified, since PROK2 can have a double function in the mechanisms underlying to neurodegeneration or neuroprotection. Here, we briefly outline the latest findings on the modulation of PROK2 and its cognate receptors following different pathological insults, providing information about their opposite neurotoxic and neuroprotective role in different pathological conditions.

scholarly journals A Simple Displacement Aptamer Assay on Resistive Pulse Sensor for Small Molecule Detection

2020 ◽  
Author(s):  
Rhushabh Maugi ◽  
bernadette gamble ◽  
david bunka ◽  
Mark Platt
Keyword(s):  
Small Molecules ◽  
Small Molecule ◽  
Label Free ◽  
Resistive Pulse ◽  
Pulse Sensor ◽  
Label Free Detection ◽  
Ssdna Aptamer ◽  
Aptamer Assay ◽  
Small Molecule Detection ◽  
Surface Changes

A universal aptamer-based sensing strategy is proposed using DNA modified nanocarriers and Resistive Pulse Sensing for the rapid and label free detection of small molecules. The surface of a magnetic nanocarrier was first modified with a ssDNA aka linker which is designed to be partially complimentary in sequence to a ssDNA aptamer. The aptamer and linker form a stable dsDNA complex on the nanocarriers surface. Upon the addition of the target molecule, a conformational change takes place where the aptamer preferentially binds to the target over the linker; causing the aptamer to be released into solution. The RPS measures the change in velocity of the nanocarrier as its surface changes from dsDNA to ssDNA, and its velocity is used as a proxy for the concentration of the target. We illustrate the versatility of the assay by demonstrating the detection of the antibiotic Moxifloxacin, and chemotherapeutics Imatinib and Irinotecan.

Originalität oder Epigonentum?

2021 ◽  
Vol 51 (1) ◽  
pp. 34-46
Author(s):  
Stefan Keym
Keyword(s):  
Franz Liszt ◽  
Function Form ◽  
Double Function

Julius Reubkes <Klaviersonate> gilt als getreues Abbild der <Sonate> h-Moll seines Lehrers Franz Liszt. Tatsächlich unterscheiden sich die beiden Werke deutlich voneinander: sowohl in ihrem Verhältnis zur Sonatenform als auch in Grundstruktur und Abwandlung ihrer Motive sowie der daraus resultierenden Dramaturgie. In der Kombination einer latenten "double-function"-Form mit einem systematisch verwendeten zyklischen Prinzip stellt Reubkes Werk einen originellen Beitrag zur Geschichte der Sonatenform dar, der auf die zyklische Sonate César Francks und die von ihr abgeleitete Theorie Vincent d'Indys vorausweist.

Behind the Scenes: A Committee and the Law, 1880s–1900s

2017 ◽  
Author(s):  
Adam Mestyan
Keyword(s):  
Legal Environment ◽  
State Institutions ◽  
Cultural Preferences ◽  
Double Function ◽  
Opera House ◽  
The Law ◽  
Administrative History ◽  
Late Ottoman

This chapter discusses the legal background of theaters in late Ottoman Egypt, starting with a microhistory of the Comité des Théâtres. Its administrative history highlights the process by which khedivial theaters became state institutions overseen financially and administratively by the Comité des Théâtres. Financial experts expressed cultural preferences through indirect censorship of the program within the Opera House. The preferences of the khedives were also taken into consideration—when and if there was no cost involved—and some favored Arab impresarios could use the Opera House. In this way, patriotism in Arabic was staged in the stage of the symbolic Opera House within the colonial frames. As a consequence, “culture” attained a double function as both legitimizing and mirroring elite power. The chapter also considers private theaters and their legal environment.

Measuring Moros

2020 ◽  
pp. 65-87
Author(s):  
Michael C. Hawkins
Keyword(s):  
Human Evolution ◽  
Human Potential ◽  
World's Fair ◽  
The Real ◽  
Olympic Athletes ◽  
Double Function ◽  
Human Difference ◽  
Biological Development ◽  
Primary Measure

This chapter examines the role of Moro bodies in the quantification of humanity at the St. Louis World's Fair. Although Moro bodies were routinely quantified in a variety of contexts, the real measure of the Moros' physical prowess was to be established in a grand athletic spectacle known as “Anthropology Days.” With the 1904 Olympics as a backdrop, anthropologist William J. McGee hoped the Anthropology Days would provide an undeniable comparison between “savage” and “civilized” athletes, thus diminishing emphasis on biological development and endorsing culture and technology as the primary measure of human difference. Ultimately, the Moros' role in the quantification of humanity served an important double function. The “semi-civilized” Moros allowed for notions of Caucasian superiority while simultaneously offering an analogy of physical and cultural improvement for all people, thus affirming the efficacy of colonial tutelage and universal human potential. In this way, the Moros were embedded firmly within the central arch of human evolution rather than on its extremes. Unlike “savage” live exhibits or indeed the exceptional Olympic athletes, Moros were more akin to average American patrons.

Double-Function Terms Again

2003 ◽  
pp. 90-104
Author(s):  
Marina Rakova
Keyword(s):  
Double Function

Double-Function Terms

2003 ◽  
pp. 74-89
Author(s):  
Marina Rakova
Keyword(s):  
Double Function
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