Intra-articular treatment of osteoarthritis of the knee: an arthroscopic and clinical comparison between sodium hyaluronate (500-730 kDa) and methylprednisolone acetate

2002 ◽  
Vol 3 (2) ◽  
pp. 89-96 ◽  
Author(s):  
L. Frizziero ◽  
I. Pasquali Ronchetti
Keyword(s):  
Sodium Hyaluronate ◽  
Osteoarthritis Of The Knee ◽  
Methylprednisolone Acetate ◽  
Clinical Comparison

Effects of sodium hyaluronate and methylprednisolone acetate on proteoglycan synthesis in equine articular cartilage explants

2005 ◽  
Vol 66 (1) ◽  
pp. 48-53 ◽  
Author(s):  
Aimie J. Doyle ◽  
Allison A. Stewart ◽  
Peter D. Constable ◽  
Jo Ann C. Eurell ◽  
David E. Freeman ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Sodium Hyaluronate ◽  
Cartilage Explants ◽  
Proteoglycan Synthesis ◽  
Methylprednisolone Acetate

scholarly journals The effectiveness of complex therapy using the injectable form of chondroitin sulfate and sodium hyaluronate with osteoarthritis of the knee joint

2019 ◽  
Vol 91 (5) ◽  
pp. 96-102 ◽  
Author(s):  
E A Belyaeva ◽  
O S Avdeeva
Keyword(s):  
Knee Joint ◽  
Chondroitin Sulfate ◽  
Sodium Hyaluronate ◽  
Control Group ◽  
Osteoarthritis Of The Knee ◽  
Complex Therapy ◽  
Group 3 ◽  
Inflammatory Drugs ◽  
Group 2 ◽  
Group 1

Aim. The study on the effectiveness of complex therapy for osteoarthritis (OA) of the knee joint was conducted in real clinical practice. Materials and methods. The survey involved 125 patients aged fr om 50 to 70 years (25 men and 100 women) with a diagnosis of knee joint OA (the III roentgenologic Kellgren-Lawrence stage).The average age of the patients was 62±3.21, the average duration of the disease - 9.4±2.8 years. Patients were randomly assigned to three groups of 35 people, the control group had 20 patients. Group 1 patients received non - steroidal anti - inflammatory drugs (NSAIDs) + Injectran(Chondroitin sulfate) 200 mg intramuscularly (I.M.) every other day No. 25.In group 2, patients received NSAIDs + Fermatron 1% 2 ml with an interval of 7 days intra - articularly (I.A.) No. 3. In group 3 - NSAIDs + Injectran 200 mg (I.M.) every other day No. 25 + Fermatron 1% 2 ml with an interval of 7 days (I.A.) No. 3. In the control group (20 people), patients received only NSAIDs. Evaluation of the symptoms was carried out using the WOMAC index before the start of thetherapy, after 8 and 12 weeks of treatment. The intensity of pain while walking was estimated on a visual analogue scale. Results. In the groups that received Injectran (I; group 1) or Fermatron (F; group 2), the dynamics of pain while walking reduction was comparable and had slightly more than 30% in both groups, the figures are reliable in comparison withinitial data (p

scholarly journals Use of Saline as a Placebo in Intra-articular Injections in Osteoarthritis: Potential Contributions to Nociceptive Pain Relief

2017 ◽  
Vol 11 (1) ◽  
pp. 16-22 ◽  
Author(s):  
David Bar-Or ◽  
Leonard T. Rael ◽  
Edward N. Brody
Keyword(s):  
Clinical Trials ◽  
Literature Search ◽  
Platelet Rich Plasma ◽  
Sodium Hyaluronate ◽  
Physiological Saline ◽  
Weight Fraction ◽  
Solute Concentration ◽  
Osteoarthritis Of The Knee ◽  
Therapeutic Effects ◽  
Limited Mobility

Background: Osteoarthritis of the knee (OAK) is a severe debilitating condition characterized by joint pain, stiffness, and resultant limited mobility. In recent years, intra-articular (IA) injections have been used to relieve symptoms and have succeeded to varying degrees either with sodium hyaluronate preparations or with a biologic. Objective: The objective of this review is to evaluate multiple studies that demonstrate some relief from the symptoms of OAK in the saline arm of various clinical trials. Method: A thorough literature search (PubMed) was performed assessing the pain efficacy of various compounds compared to saline injections in clinical trials. A total of 73 studies were identified in the literature search including a total of 5,816 patients. These clinical trials all involved the IA injection of a viscosupplement (hyaluronate, platelet rich plasma (PRP), etc.) or a biologic (the low molecular weight fraction (< 5kDa) of human serum albumin (LMWF-5A)). For all of these studies, the control arm was injection of sterile physiological saline that approximates the salt concentration and total solute concentration of blood and most tissues. Results: Based on our review of the current literature, the tested compounds performed with mixed results when compared to saline injections. Moreover, OAK is a variable disease, with severity measured on the Kellgren and Lawrence (KL) scale where various hyaluronate preparations have a therapeutic effect mostly on KL 2-3 patients while a biologic works best on KL 3-4 patients. Conclusion: Since the effect of saline injection is always greater than no treatment, the evaluations of these treatments can be confounded in clinical trials. Therefore, the question of whether there are known therapeutic effects of saline injections might explain these results.

Efficacy of Intra-articular Sodium Hyaluronate in Patients with Osteoarthritis of the Knee

2004 ◽  
Vol 17 (2) ◽  
pp. 170 ◽  
Author(s):  
Seung Sook Noh ◽  
Jae Jun Lee ◽  
Sung Mi Hwang ◽  
So Young Lim ◽  
Il Young Chung ◽  
...  
Keyword(s):  
Sodium Hyaluronate ◽  
Osteoarthritis Of The Knee

Heat-Sensitive Moxibustion in Patients with Osteoarthritis of the Knee: A Three-Armed Multicentre Randomised Active Control Trial

2015 ◽  
Vol 33 (4) ◽  
pp. 262-269 ◽  
Author(s):  
Rixin Chen ◽  
Mingren Chen ◽  
Tongsheng Su ◽  
Meiqi Zhou ◽  
Jianhua Sun ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Sodium Hyaluronate ◽  
New Drugs ◽  
Osteoarthritis Of The Knee ◽  
Controlled Clinical Trials ◽  
Guiding Principle ◽  
High Quality Evidence ◽  
Conventional Drug ◽  
Registration Number ◽  
Randomised Controlled

Background In China, heat-sensitive moxibustion (HSM) is used for knee osteoarthritis (KOA) to reduce pain and improve physical activity. However, there is little high-quality evidence of its effectiveness. Objective To evaluate the effectiveness of HSM in the treatment of KOA compared with usual care. Methods We performed a multicentre, randomised controlled trial. In total, 432 patients with KOA were randomly assigned to one of three groups (HSM, conventional moxibustion, or conventional injection with sodium hyaluronate). The primary end point was the guiding principle of clinical research on new drugs in the treatment of KOA (GPCRND-KOA). Measurements were obtained at baseline and after 1 and 6 months (month 7) of study. Result For GPCRND-KOA, there were significant differences among the three groups after treatment at months 1 and 7. Pairwise comparisons showed that HSM was more effective than the conventional drug. There was no difference in any measures between conventional moxibustion and the conventional drug. Compared with conventional moxibustion, HSM resulted in greater improvement in all outcomes. Conclusions This trial provided some evidence of the superiority of HSM in patients with KOA, suggesting that the observed differences might be due to superiority effects of a heat-sensitive point, although the effect of expectation cannot be ruled out. Trial Registration Number The trial was registered at Controlled Clinical Trials: ChiCTR-TRC-09000600.

scholarly journals Comparison of the 3 Different Injection Techniques Used in a Randomized Controlled Study Evaluating a Cross-Linked Sodium Hyaluronate Combined With Triamcinolone Hexacetonide (Cingal) for Osteoarthritis of the Knee: A Subgroup Analysis

2017 ◽  
Vol 10 ◽  
pp. 117954411772502 ◽  
Author(s):  
Robert McCormack ◽  
Martin Lamontagne ◽  
Christopher Vannabouathong ◽  
Robert T Deakon ◽  
Etienne L Belzile
Keyword(s):  
Sodium Hyaluronate ◽  
Controlled Study ◽  
Injection Technique ◽  
Osteoarthritis Of The Knee ◽  
Previous Trial ◽  
Additional Insight ◽  
Recent Trial ◽  
Treatment Groups ◽  
Randomized Controlled ◽  
Injection Techniques

A recent trial demonstrated that patients with knee osteoarthritis treated with a sodium hyaluronate and corticosteroid combination (Cingal) experienced greater pain reductions compared with those treated with sodium hyaluronate alone (Monovisc) or saline up to 3 weeks postinjection. In this study, injections were administered by 1 of 3 approaches; however, there is currently no consensus on which, if any, of these techniques produce a more favorable outcome. To provide additional insight on this topic, the results of the previous trial were reanalyzed to determine whether (1) the effect of Cingal was significant within each injection technique and (2) pain reductions were similar between injection techniques across all treatment groups. Greater pain reductions with Cingal up to 3 weeks were only significant in the anteromedial subgroup. Across all therapies, both the anteromedial and anterolateral techniques demonstrated significantly greater pain reductions than the lateral midpatellar approach at 18 and 26 weeks.

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