Genomic structure and chrosomal localization of the murine LIM class homeobox gene Lhx1

1998 ◽  
Vol 9 (1) ◽  
pp. 81-83 ◽  
Author(s):  
Tetsuya A. Fujii ◽  
Kveta Cvecklova ◽  
Debra J. Gilbert ◽  
Neal G. Copeland ◽  
Nancy A. Jenkins ◽  
...  
Keyword(s):  
Genomic Structure ◽  
Homeobox Gene

Mouse Pitx2 deficiency leads to anomalies of the ventral body wall, heart, extra- and periocular mesoderm and right pulmonary isomerism

Development ◽  
1999 ◽  
Vol 126 (24) ◽  
pp. 5749-5758 ◽  
Author(s):  
K. Kitamura ◽  
H. Miura ◽  
S. Miyagawa-Tomita ◽  
M. Yanazawa ◽  
Y. Katoh-Fukui ◽  
...  
Keyword(s):  
Body Wall ◽  
Genomic Structure ◽  
Homeobox Gene ◽  
Lacz Gene ◽  
Mitral Valves ◽  
Lateral Body ◽  
Asymmetrical Pattern ◽  
Ocular System ◽  
Deficient Mice ◽  
Pitx2 Expression

Pitx2, a bicoid-related homeobox gene, is involved in Rieger's syndrome and the left-right (L-R) asymmetrical pattern formation in body plan. In order to define the genomic structure and roles of Pitx2, we analyzed the genomic structure and generated Pitx2-deficient mice with the lacZ gene in the homeobox-containing exon of Pitx2. We were able to show that among three isoforms of Pitx2, Pitx2c shows asymmetrical expression whereas Pitx2a, Pitx2b and Pitx2c show symmetrical expression. In Pitx2(−)(/)(−) embryos there was an increase in mesodermal cells in the distal end of the left lateral body wall and an amnion continuous with the lateral body wall thickened in its mesodermal layer. These changes resulted in a failure of ventral body wall closure. In lung and heart in which Pitx2 is expressed asymmetrically, right pulmonary isomerism, atrioventricular canals with prominent swelling, and juxtaposition of the atrium were detected. The hearts failed to develop tricuspid and mitral valves and a common atrioventricular valve forms. Further, dysgenesis of the Pitx2(−)(/)(−) extraocular muscle and thickening of the mesothelial layer of cornea were observed in the ocular system where Pitx2 is expressed symmetrically, and these resulted in enophthalmos. The present study shows that Pitx2 expressed in various sites participates in morphogenesis through three types of actions: the involvement of asymmetric Pitx2 expression in the entire morphogenetic process of L-R asymmetric organs; the involvement of asymmetric Pitx2 expression in the regional morphogenesis of asymmetric organs; and finally the involvement of symmetric Pitx2 expression in the regional morphogenesis of symmetric organs.

Genomic structure, cDNA mapping, and chromosomal localization of the mouse homeobox gene, Hex

1999 ◽  
Vol 10 (10) ◽  
pp. 1023-1025 ◽  
Author(s):  
Bidyut Ghosh ◽  
Harris C. Jacobs ◽  
Leanne M. Wiedemann ◽  
Anthony Brown ◽  
Fiona K. Bedford ◽  
...  
Keyword(s):  
Chromosomal Localization ◽  
Genomic Structure ◽  
Homeobox Gene

Genomic structure, chromosomal localization and expression of the human LIM–homeobox gene LHX5

Gene ◽  
2000 ◽  
Vol 260 (1-2) ◽  
pp. 95-101 ◽  
Author(s):  
Yangu Zhao ◽  
Edit Hermesz ◽  
Maria C Yarolin ◽  
Heiner Westphal
Keyword(s):  
Chromosomal Localization ◽  
Genomic Structure ◽  
Homeobox Gene

scholarly journals Genomic Structure and Chromosomal Localization of the Mouse LIM/Homeobox Gene Lhx3

Genomics ◽  
1995 ◽  
Vol 27 (1) ◽  
pp. 27-32 ◽  
Author(s):  
Alexander B. Zhadanov ◽  
Neal G. Copeland ◽  
Debra J. Gilbert ◽  
Nancy A. Jenkins ◽  
Heiner Westphal
Keyword(s):  
Chromosomal Localization ◽  
Genomic Structure ◽  
Homeobox Gene

Genomic Structure, Promoter Sequence, and Revised Translation of Human Homeobox Gene HLX1

Genomics ◽  
1994 ◽  
Vol 22 (2) ◽  
pp. 348-355 ◽  
Author(s):  
M.A. Kennedy ◽  
J.C. Rayner ◽  
C.M. Morris
Keyword(s):  
Genomic Structure ◽  
Homeobox Gene ◽  
Promoter Sequence

Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos

Development ◽  
1992 ◽  
Vol 116 (4) ◽  
pp. 1123-1136 ◽  
Author(s):  
A.F. Candia ◽  
J. Hu ◽  
J. Crosby ◽  
P.A. Lalley ◽  
D. Noden ◽  
...  
Keyword(s):  
Genomic Structure ◽  
Expression Patterns ◽  
Homeobox Gene ◽  
Primitive Streak ◽  
The Body ◽  
Chromosome 11 ◽  
Lateral Plate ◽  
Attachment Sites ◽  
Mesenchymal Transformation ◽  
Anterior Posterior

We have isolated two mouse genes, Mox-1 and Mox-2 that, by sequence, genomic structure and expression pattern, define a novel homeobox gene family probably involved in mesodermal regionalization and somitic differentiation. Mox-1 is genetically linked to the keratin and Hox-2 genes of chromosome 11, while Mox-2 maps to chromosome 12. At primitive streak stages (approximately 7.0 days post coitum), Mox-1 is expressed in mesoderm lying posterior of the future primordial head and heart. It is not expressed in neural tissue, ectoderm, or endoderm. Mox-1 expression may therefore define an extensive ‘posterior’ domain of embryonic mesoderm before, or at the earliest stages of, patterning of the mesoderm and neuroectoderm by the Hox cluster genes. Between 7.5 and 9.5 days post coitum, Mox-1 is expressed in presomitic mesoderm, epithelial and differentiating somites (dermatome, myotome and sclerotome) and in lateral plate mesoderm. In the body of midgestation embryos, Mox-1 signal is restricted to loose undifferentiated mesenchyme. Mox-1 signal is also prominent over the mesenchyme of the heart cushions and truncus arteriosus, which arises from epithelial-mesenchymal transformation and over a limited number of craniofacial foci of neural crest-derived mesenchyme that are associated with muscle attachment sites. The expression profile of Mox-2 is similar to, but different from, that of Mox-1. For example, Mox-2 is apparently not expressed before somites form, is then expressed over the entire epithelial somite, but during somitic differentiation, Mox-2 signal rapidly becomes restricted to sclerotomal derivatives. The expression patterns of these genes suggest regulatory roles for Mox-1 and Mox-2 in the initial anterior-posterior regionalization of vertebrate embryonic mesoderm and, in addition, in somite specification and differentiation.

Genomic structure and nucleotide sequence of AML1-ETO fusion genes in children with acute myeloid leukemia

2004 ◽  
Vol 216 (03) ◽  
Author(s):  
C Gall ◽  
T Langer ◽  
M Metzler ◽  
S Viehmann ◽  
J Harbott ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Nucleotide Sequence ◽  
Myeloid Leukemia ◽  
Genomic Structure ◽  
Fusion Genes ◽  
Acute Myeloid

Identification of the Genomic Structure of Tumor Suppressor ING1 and Mutation Analysis in Head and Neck Squamous Cell Carcinomas

2005 ◽  
Vol 14 (2) ◽  
pp. 320-321
Author(s):  
Mehmet Gunduz ◽  
Esra Gunduz ◽  
Byung-Moo Min ◽  
Gene Lee ◽  
Ji-Jun Lim ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Head And Neck ◽  
Mutation Analysis ◽  
Squamous Cell ◽  
Genomic Structure ◽  
Squamous Cell Carcinomas
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