A gene polymorphism in PD-L1 promoter region is not associated with PD-L1 expression and patients’ survival in gastric cancer

2017 ◽  
Vol 66 (10) ◽  
pp. 1379-1381 ◽  
Author(s):  
Weili Wang ◽  
Ping Liao ◽  
Yijing He
Keyword(s):  
Gastric Cancer ◽  
Gene Polymorphism ◽  
Promoter Region

The Association Between XPG Gene Polymorphism and Gastric Cancer Risk

2017 ◽  
Vol 21 (10) ◽  
pp. 619-624 ◽  
Author(s):  
Yanyan Su ◽  
Chong Yang ◽  
Zongxiang Zhang
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Gene Polymorphism ◽  
Gastric Cancer Risk

scholarly journals IL-1B (C+3954T) Gene Polymorphism and Susceptibility to Gastric Cancer in the Iranian Population

2015 ◽  
Vol 16 (2) ◽  
pp. 841-844 ◽  
Author(s):  
Ahmad Ismaili ◽  
Kheirollah Yari ◽  
Mohammad-Taher Moradi ◽  
Maryam Sohrabi ◽  
Danial Kahrizi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Gene Polymorphism ◽  
Iranian Population

scholarly journals Manganese Superoxide Dismutase (MnSOD Val-9Ala) Gene Polymorphism and Susceptibility to Gastric Cancer

2015 ◽  
Vol 16 (2) ◽  
pp. 485-488 ◽  
Author(s):  
Mohammad-Taher Moradi ◽  
Kheirollah Yari ◽  
Zohreh Rahimi ◽  
Elham Kazemi ◽  
Mehrdad Shahbazi
Keyword(s):  
Gastric Cancer ◽  
Superoxide Dismutase ◽  
Gene Polymorphism ◽  
Manganese Superoxide Dismutase ◽  
Manganese Superoxide

A Genetic Variant Located in miR-146b Promoter Region Is Associated with Prognosis of Gastric Cancer

2018 ◽  
Vol 27 (7) ◽  
pp. 822-828 ◽  
Author(s):  
Weizhi Wang ◽  
Mulong Du ◽  
Zheng Li ◽  
Lei Zhang ◽  
Qing Li ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Promoter Region ◽  
Genetic Variant

scholarly journals Evaluation of MT Family Isoforms as Potential Biomarker for Predicting Progression and Prognosis in Gastric Cancer

2019 ◽  
Vol 2019 ◽  
pp. 1-15
Author(s):  
Mingfu Tong ◽  
Wenquan Lu ◽  
Hao Liu ◽  
Jian Wu ◽  
Mingzuo Jiang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Mrna Expression ◽  
Promoter Region ◽  
Gene Promoter ◽  
Distinct Type ◽  
Bioinformatic Analysis ◽  
Kaplan Meier ◽  
Potential Biomarker ◽  
Wide Range ◽  
The Individual

Background. Metallothioneins (MTs) family comprises many isoforms, most of which are frequently dysregulated in a wide range of cancers. However, the expression pattern and exact role of each distinct MT family isoform which contributes to tumorigenesis, progression, and drug resistance of gastric cancer (GC) are still unclear. Methods. Publicly available databases including Oncomine, Gene Expression Profiling Interactive Analysis (GEPIA), Kaplan-Meier plotter, SurvExpress, MethHC, cBioportal, and GeneMANIA were accessed to perform an integrated bioinformatic analysis and try to detect fundamental relationships between each MT family member and GC. Results. Bioinformatic data indicated that the mRNA expression of all MT family members was almost lowly expressed in GC compared with normal gastric tissue (P<0.05), and patients with reduced mRNA expression of each individual MT member had inconsistent prognostic value (OS, FP, PPS), which depended on the individual isoform of MT. A negative correlation between the methylation in promoter region of majority of MT members and their mRNA expression was detected from MethHC database (p<0.001). Data downloaded from TCGA revealed that MTs were rarely mutated in GC patients and MT2A was frequently regulated by other three genes (FOS, JUN, SP1) in GC patients. Conclusion. MTs were nearly downregulated, and distinct type of MT harbored different prognostic role in GC patients. Methylation in gene promoter region of MTs partially contributed to their reduced expression in GC. Our comprehensive analyses from multiple independent databases may further lead researches to explore MT-targeting reagents or potential diagnostic and prognostic markers for GC patients.

scholarly journals Identification of High-Frequency Methylation Sites in RNF180 Promoter Region Affecting Expression and Their Relationship with Prognosis of Gastric Cancer

2020 ◽  
Vol Volume 12 ◽  
pp. 3389-3399
Author(s):  
Fang Han ◽  
Shuang Liu ◽  
Jingjing Jing ◽  
Hao Li ◽  
Yuan Yuan ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
High Frequency ◽  
Promoter Region

CDH1 −160C>A gene polymorphism is an ethnicity-dependent risk factor for gastric cancer

Cytokine ◽  
2011 ◽  
Vol 55 (2) ◽  
pp. 266-273 ◽  
Author(s):  
Bo Chen ◽  
Yong Zhou ◽  
Ping Yang ◽  
Liu Liu ◽  
Xian-Peng Qin ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Risk Factor ◽  
Gene Polymorphism
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