scholarly journals Identification of High-Frequency Methylation Sites in RNF180 Promoter Region Affecting Expression and Their Relationship with Prognosis of Gastric Cancer

2020 ◽  
Vol Volume 12 ◽  
pp. 3389-3399
Author(s):  
Fang Han ◽  
Shuang Liu ◽  
Jingjing Jing ◽  
Hao Li ◽  
Yuan Yuan ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
High Frequency ◽  
Promoter Region

A Genetic Variant Located in miR-146b Promoter Region Is Associated with Prognosis of Gastric Cancer

2018 ◽  
Vol 27 (7) ◽  
pp. 822-828 ◽  
Author(s):  
Weizhi Wang ◽  
Mulong Du ◽  
Zheng Li ◽  
Lei Zhang ◽  
Qing Li ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Promoter Region ◽  
Genetic Variant

scholarly journals Evaluation of MT Family Isoforms as Potential Biomarker for Predicting Progression and Prognosis in Gastric Cancer

2019 ◽  
Vol 2019 ◽  
pp. 1-15
Author(s):  
Mingfu Tong ◽  
Wenquan Lu ◽  
Hao Liu ◽  
Jian Wu ◽  
Mingzuo Jiang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Mrna Expression ◽  
Promoter Region ◽  
Gene Promoter ◽  
Distinct Type ◽  
Bioinformatic Analysis ◽  
Kaplan Meier ◽  
Potential Biomarker ◽  
Wide Range ◽  
The Individual

Background. Metallothioneins (MTs) family comprises many isoforms, most of which are frequently dysregulated in a wide range of cancers. However, the expression pattern and exact role of each distinct MT family isoform which contributes to tumorigenesis, progression, and drug resistance of gastric cancer (GC) are still unclear. Methods. Publicly available databases including Oncomine, Gene Expression Profiling Interactive Analysis (GEPIA), Kaplan-Meier plotter, SurvExpress, MethHC, cBioportal, and GeneMANIA were accessed to perform an integrated bioinformatic analysis and try to detect fundamental relationships between each MT family member and GC. Results. Bioinformatic data indicated that the mRNA expression of all MT family members was almost lowly expressed in GC compared with normal gastric tissue (P<0.05), and patients with reduced mRNA expression of each individual MT member had inconsistent prognostic value (OS, FP, PPS), which depended on the individual isoform of MT. A negative correlation between the methylation in promoter region of majority of MT members and their mRNA expression was detected from MethHC database (p<0.001). Data downloaded from TCGA revealed that MTs were rarely mutated in GC patients and MT2A was frequently regulated by other three genes (FOS, JUN, SP1) in GC patients. Conclusion. MTs were nearly downregulated, and distinct type of MT harbored different prognostic role in GC patients. Methylation in gene promoter region of MTs partially contributed to their reduced expression in GC. Our comprehensive analyses from multiple independent databases may further lead researches to explore MT-targeting reagents or potential diagnostic and prognostic markers for GC patients.

High frequency of gastric cancer precursor lesions in patients with gastric xanthelasma

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Suleyman Sayar ◽  
Gülçiçek Ayrancı ◽  
Kemal Kürbüz ◽  
Çağatay Ak ◽  
Ebru Tarıkçı Kılıç ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
High Frequency ◽  
Precursor Lesions

Association and Prognostic Significance of the Functional −1562C/T Polymorphism in the Promoter Region of MMP-9 in Turkish Patients with Gastric Cancer

2015 ◽  
Vol 21 (4) ◽  
pp. 1243-1247 ◽  
Author(s):  
Nilufer Avcı ◽  
Mehmet Ture ◽  
Adem Deligonul ◽  
Erdem Cubukcu ◽  
Omer Fatih Olmez ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Promoter Region ◽  
Prognostic Significance ◽  
Turkish Patients

Birt-Hogg-Dubé (BHD) gene mutations in human gastric cancer with high frequency microsatellite instability

2007 ◽  
Vol 248 (1) ◽  
pp. 103-111 ◽  
Author(s):  
Wenquan Jiang ◽  
Hiroaki Fujii ◽  
Toshiharu Matsumoto ◽  
Naomi Ohtsuji ◽  
Masahiko Tsurumaru ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Microsatellite Instability ◽  
High Frequency ◽  
Gene Mutations ◽  
Human Gastric Cancer

scholarly journals Human ZNF312b oncogene is regulated by Sp1 binding to its promoter region through DNA demethylation and histone acetylation in gastric cancer

2011 ◽  
Vol 129 (9) ◽  
pp. 2124-2133 ◽  
Author(s):  
In-Sung Song ◽  
Ga-Hee Ha ◽  
Jeong-Min Kim ◽  
So-Young Jeong ◽  
Han-Chul Lee ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Histone Acetylation ◽  
Promoter Region ◽  
Dna Demethylation
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