Advances in nuclear medicine instrumentation: considerations in the design and selection of an imaging system

1998 ◽  
Vol 25 (10) ◽  
pp. 1453-1466 ◽  
Author(s):  
Jonathan M. Links
Keyword(s):  
Nuclear Medicine ◽  
Imaging System ◽  
Nuclear Medicine Instrumentation ◽  
Selection Of

scholarly journals Correction for the Partial Volume Effects (PVE) in Nuclear Medicine Imaging: A Post-Reconstruction Analytic Method

2021 ◽  
Vol 11 (14) ◽  
pp. 6460
Author(s):  
Fabio Di Martino ◽  
Patrizio Barca ◽  
Eleonora Bortoli ◽  
Alessia Giuliano ◽  
Duccio Volterrani
Keyword(s):  
Nuclear Medicine ◽  
Imaging System ◽  
Tomographic Reconstruction ◽  
Mathematical Expression ◽  
Reconstruction Algorithm ◽  
Volume Effect ◽  
Nuclear Medicine Imaging ◽  
Theoretical Derivation ◽  
Reconstruction Process ◽  
Partial Volume

Quantitative analyses in nuclear medicine are increasingly used, both for diagnostic and therapeutic purposes. The Partial Volume Effect (PVE) is the most important factor of loss of quantification in Nuclear Medicine, especially for evaluation in Region of Interest (ROI) smaller than the Full Width at Half Maximum (FWHM) of the PSF. The aim of this work is to present a new approach for the correction of PVE, using a post-reconstruction process starting from a mathematical expression, which only requires the knowledge of the FWHM of the final PSF of the imaging system used. After the presentation of the theoretical derivation, the experimental evaluation of this method is performed using a PET/CT hybrid system and acquiring the IEC NEMA phantom with six spherical “hot” ROIs (with diameters of 10, 13, 17, 22, 28, and 37 mm) and a homogeneous “colder” background. In order to evaluate the recovery of quantitative data, the effect of statistical noise (different acquisition times), tomographic reconstruction algorithm with and without time-of-flight (TOF) and different signal-to-background activity concentration ratio (3:1 and 10:1) was studied. The application of the corrective method allows recovering the loss of quantification due to PVE for all sizes of spheres acquired, with a final accuracy less than 17%, for lesion dimensions larger than two FWHM and for acquisition times equal to or greater than two minutes.

TH-D-330A-03: Development of a High Resolution Imaging System for Nuclear Medicine

2006 ◽  
Vol 33 (6Part22) ◽  
pp. 2278-2278
Author(s):  
D Roa ◽  
R Smither ◽  
Y Shieh ◽  
K Nie ◽  
X Zhang ◽  
...  
Keyword(s):  
Nuclear Medicine ◽  
High Resolution ◽  
Imaging System ◽  
High Resolution Imaging ◽  
Resolution Imaging

Modular 64×64 CdZnTe Arrays With Multiplexer Readout for High-Resolution Nuclear Medicine Imaging

1997 ◽  
Vol 487 ◽  
Author(s):  
J. M. Woolfenden ◽  
H. B. Barber ◽  
H. H. Barrett ◽  
E. L. Dereniak ◽  
J. D. Eskin ◽  
...  
Keyword(s):  
Nuclear Medicine ◽  
High Resolution ◽  
Spatial Resolution ◽  
Personal Computer ◽  
Imaging System ◽  
Radiation Detectors ◽  
Readout Circuit ◽  
Nuclear Medicine Imaging ◽  
Pixel Pitch

AbstractWe are developing modular arrays of CdZnTe radiation detectors for high-resolution nuclear medicine imaging. Each detector is delineated into a 64×64 array of pixels; the pixel pitch is 380 jim. Each pixel is connected to a corresponding pad on a multiplexer readout circuit. The imaging system is controlled by a personal computer. We obtained images of standard nuclear medicine phantoms in which the spatial resolution of approximately 1.5 mm was limited by the collimator that was used. Significant improvements in spatial resolution should be possible with different collimator designs. These results are promising for high-resolution nuclear medicine imaging.

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