Modular 64×64 CdZnTe Arrays With Multiplexer Readout for High-Resolution Nuclear Medicine Imaging

1997 ◽  
Vol 487 ◽  
Author(s):  
J. M. Woolfenden ◽  
H. B. Barber ◽  
H. H. Barrett ◽  
E. L. Dereniak ◽  
J. D. Eskin ◽  
...  
Keyword(s):  
Nuclear Medicine ◽  
High Resolution ◽  
Spatial Resolution ◽  
Personal Computer ◽  
Imaging System ◽  
Radiation Detectors ◽  
Readout Circuit ◽  
Nuclear Medicine Imaging ◽  
Pixel Pitch

AbstractWe are developing modular arrays of CdZnTe radiation detectors for high-resolution nuclear medicine imaging. Each detector is delineated into a 64×64 array of pixels; the pixel pitch is 380 jim. Each pixel is connected to a corresponding pad on a multiplexer readout circuit. The imaging system is controlled by a personal computer. We obtained images of standard nuclear medicine phantoms in which the spatial resolution of approximately 1.5 mm was limited by the collimator that was used. Significant improvements in spatial resolution should be possible with different collimator designs. These results are promising for high-resolution nuclear medicine imaging.

Modular 64×64 CdZnTe Arrays With Multiplexer Readout for High-Resolution Nuclear Medicine Imaging

1997 ◽  
Vol 484 ◽  
Author(s):  
J. M. Woolfenden ◽  
H. B. Barber ◽  
H. H. Barrett ◽  
E. L. Dereniak ◽  
J. D. Eskin ◽  
...  
Keyword(s):  
Nuclear Medicine ◽  
High Resolution ◽  
Spatial Resolution ◽  
Personal Computer ◽  
Imaging System ◽  
Radiation Detectors ◽  
Readout Circuit ◽  
Nuclear Medicine Imaging ◽  
Pixel Pitch

AbstractWe are developing modular arrays of CdZnTe radiation detectors for high-resolution nuclear medicine imaging. Each detector is delineated into a 64×64 array of pixels; the pixel pitch is 380 ptm. Each pixel is connected to a corresponding pad on a multiplexer readout circuit. The imaging system is controlled by a personal computer. We obtained images of standard nuclear medicine phantoms in which the spatial resolution of approximately 1.5 mm was limited by the collimator that was used. Significant improvements in spatial resolution should be possible with different collimator designs. These results are promising for high-resolution nuclear medicine imaging.

scholarly journals Correction for the Partial Volume Effects (PVE) in Nuclear Medicine Imaging: A Post-Reconstruction Analytic Method

2021 ◽  
Vol 11 (14) ◽  
pp. 6460
Author(s):  
Fabio Di Martino ◽  
Patrizio Barca ◽  
Eleonora Bortoli ◽  
Alessia Giuliano ◽  
Duccio Volterrani
Keyword(s):  
Nuclear Medicine ◽  
Imaging System ◽  
Tomographic Reconstruction ◽  
Mathematical Expression ◽  
Reconstruction Algorithm ◽  
Volume Effect ◽  
Nuclear Medicine Imaging ◽  
Theoretical Derivation ◽  
Reconstruction Process ◽  
Partial Volume

Quantitative analyses in nuclear medicine are increasingly used, both for diagnostic and therapeutic purposes. The Partial Volume Effect (PVE) is the most important factor of loss of quantification in Nuclear Medicine, especially for evaluation in Region of Interest (ROI) smaller than the Full Width at Half Maximum (FWHM) of the PSF. The aim of this work is to present a new approach for the correction of PVE, using a post-reconstruction process starting from a mathematical expression, which only requires the knowledge of the FWHM of the final PSF of the imaging system used. After the presentation of the theoretical derivation, the experimental evaluation of this method is performed using a PET/CT hybrid system and acquiring the IEC NEMA phantom with six spherical “hot” ROIs (with diameters of 10, 13, 17, 22, 28, and 37 mm) and a homogeneous “colder” background. In order to evaluate the recovery of quantitative data, the effect of statistical noise (different acquisition times), tomographic reconstruction algorithm with and without time-of-flight (TOF) and different signal-to-background activity concentration ratio (3:1 and 10:1) was studied. The application of the corrective method allows recovering the loss of quantification due to PVE for all sizes of spheres acquired, with a final accuracy less than 17%, for lesion dimensions larger than two FWHM and for acquisition times equal to or greater than two minutes.

scholarly journals 73.1: Large-Area Plasma-Panel Radiation Detectors for Nuclear Medicine Imaging to Homeland Security and the Super Large Hadron Collider

2010 ◽  
Vol 41 (1) ◽  
pp. 1080 ◽  
Author(s):  
Peter S. Friedman ◽  
Robert Ball ◽  
J. Wehrley Chapman ◽  
Daniel S. Levin ◽  
Curtis Weaverdyck ◽  
...  
Keyword(s):  
Nuclear Medicine ◽  
Large Hadron Collider ◽  
Homeland Security ◽  
Hadron Collider ◽  
Radiation Detectors ◽  
Nuclear Medicine Imaging ◽  
Large Area

TH-D-330A-03: Development of a High Resolution Imaging System for Nuclear Medicine

2006 ◽  
Vol 33 (6Part22) ◽  
pp. 2278-2278
Author(s):  
D Roa ◽  
R Smither ◽  
Y Shieh ◽  
K Nie ◽  
X Zhang ◽  
...  
Keyword(s):  
Nuclear Medicine ◽  
High Resolution ◽  
Imaging System ◽  
High Resolution Imaging ◽  
Resolution Imaging

scholarly journals Wide Swath and High Resolution Airborne HyperSpectral Imaging System and Flight Validation

Sensors ◽  
2019 ◽  
Vol 19 (7) ◽  
pp. 1667 ◽  
Author(s):  
Dong Zhang ◽  
Liyin Yuan ◽  
Shengwei Wang ◽  
Hongxuan Yu ◽  
Changxing Zhang ◽  
...  
Keyword(s):  
High Resolution ◽  
Spatial Resolution ◽  
Spectral Resolution ◽  
High Efficiency ◽  
High Spatial Resolution ◽  
Imaging System ◽  
High Sensitivity ◽  
Field Of View ◽  
High Spectral Resolution ◽  
Wide Swath

Wide Swath and High Resolution Airborne Pushbroom Hyperspectral Imager (WiSHiRaPHI) is the new-generation airborne hyperspectral imager instrument of China, aimed at acquiring accurate spectral curve of target on the ground with both high spatial resolution and high spectral resolution. The spectral sampling interval of WiSHiRaPHI is 2.4 nm and the spectral resolution is 3.5 nm (FWHM), integrating 256 channels coving from 400 nm to 1000 nm. The instrument has a 40-degree field of view (FOV), 0.125 mrad instantaneous field of view (IFOV) and can work in high spectral resolution mode, high spatial resolution mode and high sensitivity mode for different applications, which can adapt to the Velocity to Height Ratio (VHR) lower than 0.04. The integration has been finished, and several airborne flight validation experiments have been conducted. The results showed the system’s excellent performance and high efficiency.

scholarly journals Simultaneous Dual-Color Fluorescence Microscope: A Characterization Study

2013 ◽  
Vol 36 (5-6) ◽  
pp. 163-172
Author(s):  
Zheng Li ◽  
Xiaodong Chen ◽  
Liqiang Ren ◽  
Jie Song ◽  
Yuhua Li ◽  
...  
Keyword(s):  
High Resolution ◽  
Transfer Function ◽  
Spatial Resolution ◽  
Imaging System ◽  
Fluorescence Microscope ◽  
Chromosomal Analysis ◽  
Dual Band ◽  
Geometric Distortion ◽  
Dual Color ◽  
Characterization Study

Background: High spatial resolution and geometric accuracy is crucial for chromosomal analysis of clinical cytogenetic applications. High resolution and rapid simultaneous acquisition of multiple fluorescent wavelengths can be achieved by utilizing concurrent imaging with multiple detectors. However, such class of microscopic systems functions differently from traditional fluorescence microscopes.Objective: To develop a practical characterization framework to assess and optimize the performance of a high resolution and dual-color fluorescence microscope designed for clinical chromosomal analysis.Methods: A dual-band microscopic imaging system utilizes a dichroic mirror, two sets of specially selected optical filters, and two detectors to simultaneously acquire two fluorescent wavelengths. The system’s geometric distortion, linearity, the modulation transfer function, and the dual detectors’ alignment were characterized.Results: Experiment results show that the geometric distortion at lens periphery is less than 1%. Both fluorescent channels show linear signal responses, but there exists discrepancy between the two due to the detectors’ non-uniform response ratio to different wavelengths. In terms of the spatial resolution, the two contrast transfer function curves trend agreeably with the spatial frequency. The alignment measurement allows quantitatively assessing the cameras' alignment. A result image of adjusted alignment is demonstrated to show the reduced discrepancy by using the alignment measurement method.Conclusions: In this paper, we present a system characterization study and its methods for a specially designed imaging system for clinical cytogenetic applications. The presented characterization methods are not only unique to this dual-color imaging system but also applicable to evaluation and optimization of other similar multi-color microscopic image systems for improving their clinical utilities for future cytogenetic applications.

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