Genomic organization and chromosomal localization of the human gene encoding the T-cell receptor-interacting molecule (TRIM)

2000 ◽  
Vol 51 (2) ◽  
pp. 154-158 ◽  
Author(s):  
C. Hübener ◽  
A. Mincheva ◽  
P. Lichter ◽  
B. Schraven ◽  
E. Bruyns
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Genomic Organization ◽  
Chromosomal Localization ◽  
Human Gene ◽  
Cell Receptor ◽  
Gene Encoding

scholarly journals Genomic Organization of the Chicken T-Cell Receptor β Chain D-J-C Region

2004 ◽  
Vol 66 (12) ◽  
pp. 1509-1515 ◽  
Author(s):  
Akiko SHIGETA ◽  
Masaharu SATO ◽  
Tsuyoshi KAWASHIMA ◽  
Hiroyuki HORIUCHI ◽  
Haruo MATSUDA ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Genomic Organization ◽  
Cell Receptor ◽  
Β Chain

scholarly journals Genomic organization of the mouse T cell receptor V alpha family.

1990 ◽  
Vol 9 (7) ◽  
pp. 2141-2150 ◽  
Author(s):  
E. Jouvin-Marche ◽  
I. Hue ◽  
P. N. Marche ◽  
C. Liebe-Gris ◽  
J. P. Marolleau ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Genomic Organization ◽  
Cell Receptor

The gene encoding the T-cell receptor α-chain maps close to the Np-2 locus on mouse chromosome 14

Nature ◽  
1985 ◽  
Vol 314 (6008) ◽  
pp. 271-273 ◽  
Author(s):  
Zlatko DembiĆ ◽  
Wilhelm Bannwarth ◽  
Benjamin A. Taylor ◽  
Michael Steinmetz
Keyword(s):  
T Cell ◽  
Mouse Chromosome ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Chromosome 14 ◽  
Gene Encoding ◽  
Α Chain ◽  
Chain Maps

scholarly journals Regulation of pre-T cell receptor (pT alpha-TCR beta) gene expression during human thymic development.

1996 ◽  
Vol 184 (2) ◽  
pp. 519-530 ◽  
Author(s):  
A R Ramiro ◽  
C Trigueros ◽  
C Márquez ◽  
J L San Millán ◽  
M L Toribio
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
T Cell Development ◽  
Cell Receptor ◽  
Beta Chain ◽  
Thymocyte Development ◽  
Gene Encoding ◽  
Thymic Development ◽  
Alpha Beta ◽  
Beta Gene

In murine T cell development, early thymocytes that productively rearrange the T cell receptor (TCR) beta locus are selected to continue maturation, before TCR alpha expression, by means of a pre-TCR alpha- (pT alpha-) TCR beta heterodimer (pre-TCR). The aim of this study was to identify equivalent stages in human thymocyte development. We show here that variable-diversity-joining region TCR beta rearrangement and the expression of full-length TCR beta transcripts have been initiated in some immature thymocytes at the TCR alpha/beta- CD4+CD8- stage, and become common in a downstream subset of TCR alpha/beta- CD4+CD8+ thymocytes that is highly enriched in large cycling cells. TCR beta chain expression was hardly detected in TCR alpha/beta- CD4+CD8- thymocytes, whereas cytoplasmic TCR beta chain was found in virtually all TCR alpha/beta- CD4+CD8+ blasts. In addition, a TCR beta complex distinct from the mature TCR alpha/beta heterodimer was immunoprecipitated only from the latter subset. cDNA derived from TCR alpha/beta- CD4+CD8+ blasts allowed us to identify and clone the gene encoding the human pT alpha chain, and to examine its expression at different stages of thymocyte development. Our results show that high pT alpha transcription occurs only in CD4+CD8- and CD4+CD8+ TCR alpha/beta- thymocytes, whereas it is weaker in earlier and later stages of development. Based on these results, we propose that the transition from TCR alpha/beta- CD4+CD8- to TCR alpha/beta- CD4+CD8+ thymocytes represents a critical developmental stage at which the successful expression of TCR beta promotes the clonal expansion and further maturation of human thymocytes, independent of TCR alpha.

Genomic organization of the genes encoding mouse T-cell receptor α-chain

Nature ◽  
1985 ◽  
Vol 316 (6031) ◽  
pp. 832-836 ◽  
Author(s):  
Astar Winoto ◽  
Shelley Mjolsness ◽  
Leroy Hood
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Genomic Organization ◽  
Cell Receptor ◽  
Genes Encoding ◽  
Α Chain

Genomic Organization of the Human T-Cell Receptor Variable α (TCRAV) Gene Cluster

Genomics ◽  
1995 ◽  
Vol 28 (2) ◽  
pp. 131-139 ◽  
Author(s):  
Mark R. Ibberson ◽  
John P. Copier ◽  
Alex K. So
Keyword(s):  
T Cell ◽  
Gene Cluster ◽  
T Cell Receptor ◽  
Genomic Organization ◽  
Cell Receptor ◽  
Human T Cell

Chromosomal localization of the human T cell receptor β-chain genes

Cell ◽  
1985 ◽  
Vol 41 (1) ◽  
pp. 335 ◽  
Author(s):  
Michelle M. Le Beau ◽  
Manuel O. Diaz ◽  
Janet D. Rowley ◽  
Tak W. Mak
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Chromosomal Localization ◽  
Cell Receptor ◽  
Human T Cell ◽  
Β Chain
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