The gene encoding the T-cell receptor α-chain maps close to the Np-2 locus on mouse chromosome 14

Nature ◽  
1985 ◽  
Vol 314 (6008) ◽  
pp. 271-273 ◽  
Author(s):  
Zlatko DembiĆ ◽  
Wilhelm Bannwarth ◽  
Benjamin A. Taylor ◽  
Michael Steinmetz
Keyword(s):  
T Cell ◽  
Mouse Chromosome ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Chromosome 14 ◽  
Gene Encoding ◽  
Α Chain ◽  
Chain Maps

The human T-cell receptor α-chain gene maps to chromosome 14

Nature ◽  
1985 ◽  
Vol 314 (6008) ◽  
pp. 273-274 ◽  
Author(s):  
M. K. L. Collins ◽  
P. N. Goodfellow ◽  
N. K. Spurr ◽  
E. Solomon ◽  
G. Tanigawa ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Chain Gene ◽  
Chromosome 14 ◽  
Human T Cell ◽  
Α Chain ◽  
Gene Maps

scholarly journals Alteration of Interleukin 4 Production Results in the Inhibition of T Helper Type 2 Cell–Dominated Inflammatory Bowel Disease in T Cell Receptor α Chain–Deficient Mice

1999 ◽  
Vol 190 (5) ◽  
pp. 607-616 ◽  
Author(s):  
Hideki Iijima ◽  
Ichiro Takahashi ◽  
Daisuke Kishi ◽  
Jin-Kyung Kim ◽  
Sunao Kawano ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
T Cells ◽  
T Cell ◽  
T Cell Receptor ◽  
Bowel Disease ◽  
Cell Receptor ◽  
Interleukin 4 ◽  
T Helper ◽  
Inflammatory Bowel ◽  
Α Chain

T cell receptor α chain–deficient (TCR-α−/−) mice are known to spontaneously develop inflammatory bowel disease (IBD). The colitis that develops in these mice is associated with increased numbers of T helper cell (Th)2-type CD4+TCR-ββ (CD4+ββ) T cells producing predominantly interleukin (IL)-4. To investigate the role of these Th2-type CD4+ββ T cells, we treated TCR-α−/− mice with anti–IL-4 monoclonal antibody (mAb). Approximately 60% of TCR-α−/− mice, including those treated with mock Ab and those left untreated, spontaneously developed IBD. However, anti–IL-4 mAb–treated mice exhibited no clinical or histological signs of IBD, and their levels of mucosal and systemic Ab responses were lower than those of mock Ab–treated mice. Although TCR-α−/− mice treated with either specific or mock Ab developed CD4+ββ T cells, only those treated with anti–IL-4 mAb showed a decrease in Th2-type cytokine production at the level of mRNA and protein and an increase in interferon γ–specific expression. These findings suggest that IL-4–producing Th2-type CD4+ββ T cells play a major immunopathological role in the induction of IBD in TCR-α−/− mice, a role that anti–IL-4 mAb inhibits by causing Th2-type CD4+ββ T cells to shift to the Th1 type.

Restricted usage of T-cell receptor α-chain variable region (TCRAV) and T-cell receptor β-chain variable region (TCRBV) repertoires after human allogeneic haematopoietic transplantation

2000 ◽  
Vol 109 (4) ◽  
pp. 759-769 ◽  
Author(s):  
Takaji Matsutani ◽  
Takeshi Yoshioka ◽  
Yuji Tsuruta ◽  
Shoji Iwagami ◽  
Tomoko Toyosaki-Maeda ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Variable Region ◽  
Cell Receptor ◽  
Α Chain ◽  
Β Chain

Structure and diversity of the T-cell receptor α chain in rhesus macaque and chimpanzee

1995 ◽  
Vol 43 (2) ◽  
pp. 85-94 ◽  
Author(s):  
Cornelia Thiel ◽  
Ronald E. Bontrop ◽  
Jerry S. Lanchbury
Keyword(s):  
T Cell ◽  
Rhesus Macaque ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Α Chain

Sequence diversity of T cell receptor α chain transcripts from BALB/c thymus

1992 ◽  
Vol 29 (12) ◽  
pp. 1447-1455 ◽  
Author(s):  
Matthew E. Roth ◽  
Benjamin A. Tjoa ◽  
Carol J. Schlueter ◽  
Erik R. Wilson ◽  
Brian C. Lunn ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Sequence Diversity ◽  
Α Chain

T cell development and repertoire of mice expressing a single T cell receptor α chain

1995 ◽  
Vol 25 (9) ◽  
pp. 2650-2655 ◽  
Author(s):  
Daniel Brändle ◽  
Karin Brduscha-Riem ◽  
Adrian C. Hayday ◽  
Michael J. Owen ◽  
Hans Hengartner ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
T Cell Development ◽  
Cell Receptor ◽  
Cell Development ◽  
Α Chain

The basics of mechanotransduction

2018 ◽  
Vol 11 (556) ◽  
pp. eaau2223
Author(s):  
Erin R. Williams
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Transmembrane Domain ◽  
Cell Receptor ◽  
Α Chain

Basic residues in the transmembrane domain of the T cell receptor α chain promote its association with CD3 signaling chains.

Cytoplasmic tall of the T-cell receptor α-chain is involved in down-regulation, but not signalling

1997 ◽  
Vol 56 ◽  
pp. 2-3
Author(s):  
B.Thomas Báckstróm ◽  
Bent Rubin ◽  
Annick Peter ◽  
Georg Tiefenthaler ◽  
Ed Palmer
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Down Regulation ◽  
Α Chain
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