Genomic organization of the genes encoding mouse T-cell receptor α-chain

Nature ◽  
1985 ◽  
Vol 316 (6031) ◽  
pp. 832-836 ◽  
Author(s):  
Astar Winoto ◽  
Shelley Mjolsness ◽  
Leroy Hood
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Genomic Organization ◽  
Cell Receptor ◽  
Genes Encoding ◽  
Α Chain

scholarly journals Alteration of Interleukin 4 Production Results in the Inhibition of T Helper Type 2 Cell–Dominated Inflammatory Bowel Disease in T Cell Receptor α Chain–Deficient Mice

1999 ◽  
Vol 190 (5) ◽  
pp. 607-616 ◽  
Author(s):  
Hideki Iijima ◽  
Ichiro Takahashi ◽  
Daisuke Kishi ◽  
Jin-Kyung Kim ◽  
Sunao Kawano ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
T Cells ◽  
T Cell ◽  
T Cell Receptor ◽  
Bowel Disease ◽  
Cell Receptor ◽  
Interleukin 4 ◽  
T Helper ◽  
Inflammatory Bowel ◽  
Α Chain

T cell receptor α chain–deficient (TCR-α−/−) mice are known to spontaneously develop inflammatory bowel disease (IBD). The colitis that develops in these mice is associated with increased numbers of T helper cell (Th)2-type CD4+TCR-ββ (CD4+ββ) T cells producing predominantly interleukin (IL)-4. To investigate the role of these Th2-type CD4+ββ T cells, we treated TCR-α−/− mice with anti–IL-4 monoclonal antibody (mAb). Approximately 60% of TCR-α−/− mice, including those treated with mock Ab and those left untreated, spontaneously developed IBD. However, anti–IL-4 mAb–treated mice exhibited no clinical or histological signs of IBD, and their levels of mucosal and systemic Ab responses were lower than those of mock Ab–treated mice. Although TCR-α−/− mice treated with either specific or mock Ab developed CD4+ββ T cells, only those treated with anti–IL-4 mAb showed a decrease in Th2-type cytokine production at the level of mRNA and protein and an increase in interferon γ–specific expression. These findings suggest that IL-4–producing Th2-type CD4+ββ T cells play a major immunopathological role in the induction of IBD in TCR-α−/− mice, a role that anti–IL-4 mAb inhibits by causing Th2-type CD4+ββ T cells to shift to the Th1 type.

Restricted usage of T-cell receptor α-chain variable region (TCRAV) and T-cell receptor β-chain variable region (TCRBV) repertoires after human allogeneic haematopoietic transplantation

2000 ◽  
Vol 109 (4) ◽  
pp. 759-769 ◽  
Author(s):  
Takaji Matsutani ◽  
Takeshi Yoshioka ◽  
Yuji Tsuruta ◽  
Shoji Iwagami ◽  
Tomoko Toyosaki-Maeda ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Variable Region ◽  
Cell Receptor ◽  
Α Chain ◽  
Β Chain

scholarly journals Genomic Organization of the Chicken T-Cell Receptor β Chain D-J-C Region

2004 ◽  
Vol 66 (12) ◽  
pp. 1509-1515 ◽  
Author(s):  
Akiko SHIGETA ◽  
Masaharu SATO ◽  
Tsuyoshi KAWASHIMA ◽  
Hiroyuki HORIUCHI ◽  
Haruo MATSUDA ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Genomic Organization ◽  
Cell Receptor ◽  
Β Chain

Structure and diversity of the T-cell receptor α chain in rhesus macaque and chimpanzee

1995 ◽  
Vol 43 (2) ◽  
pp. 85-94 ◽  
Author(s):  
Cornelia Thiel ◽  
Ronald E. Bontrop ◽  
Jerry S. Lanchbury
Keyword(s):  
T Cell ◽  
Rhesus Macaque ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Α Chain

scholarly journals Genomic organization of the mouse T cell receptor V alpha family.

1990 ◽  
Vol 9 (7) ◽  
pp. 2141-2150 ◽  
Author(s):  
E. Jouvin-Marche ◽  
I. Hue ◽  
P. N. Marche ◽  
C. Liebe-Gris ◽  
J. P. Marolleau ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Genomic Organization ◽  
Cell Receptor

Sequence diversity of T cell receptor α chain transcripts from BALB/c thymus

1992 ◽  
Vol 29 (12) ◽  
pp. 1447-1455 ◽  
Author(s):  
Matthew E. Roth ◽  
Benjamin A. Tjoa ◽  
Carol J. Schlueter ◽  
Erik R. Wilson ◽  
Brian C. Lunn ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Sequence Diversity ◽  
Α Chain

T cell development and repertoire of mice expressing a single T cell receptor α chain

1995 ◽  
Vol 25 (9) ◽  
pp. 2650-2655 ◽  
Author(s):  
Daniel Brändle ◽  
Karin Brduscha-Riem ◽  
Adrian C. Hayday ◽  
Michael J. Owen ◽  
Hans Hengartner ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
T Cell Development ◽  
Cell Receptor ◽  
Cell Development ◽  
Α Chain

The basics of mechanotransduction

2018 ◽  
Vol 11 (556) ◽  
pp. eaau2223
Author(s):  
Erin R. Williams
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Transmembrane Domain ◽  
Cell Receptor ◽  
Α Chain

Basic residues in the transmembrane domain of the T cell receptor α chain promote its association with CD3 signaling chains.

Cytoplasmic tall of the T-cell receptor α-chain is involved in down-regulation, but not signalling

1997 ◽  
Vol 56 ◽  
pp. 2-3
Author(s):  
B.Thomas Báckstróm ◽  
Bent Rubin ◽  
Annick Peter ◽  
Georg Tiefenthaler ◽  
Ed Palmer
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Down Regulation ◽  
Α Chain
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