Theoretical evaluation of cell membrane ion channel activation by applied magnetic fields

2000 ◽  
Vol 29 (6) ◽  
pp. 455-456 ◽  
Author(s):  
Tim G. St. Pierre ◽  
Jon Dobson
Keyword(s):  
Magnetic Fields ◽  
Cell Membrane ◽  
Ion Channel ◽  
Theoretical Evaluation ◽  
Channel Activation

scholarly journals Possible Magneto-Mechanical and Magneto-Thermal Mechanisms of Ion Channel Activation by Iron-Loaded Ferritin in Magnetogenetics

2019 ◽  
Author(s):  
Mladen Barbic
Keyword(s):  
Ion Channels ◽  
Magnetic Fields ◽  
Ion Channel ◽  
New Technology ◽  
Genetically Engineered ◽  
Channel Activation ◽  
Iron Storage ◽  
Magnetic Spin ◽  
Genetic Constructs

AbstractThe palette of tools for stimulation and regulation of neural activity is continually expanding. One of the new methods being introduced is magnetogenetics, where mechano-sensitive and thermo-sensitive ion channels are genetically engineered to be closely coupled to the iron-storage protein ferritin. Such genetic constructs could provide a powerful new way of non-invasively activating ion channels in-vivo using external magnetic fields that easily penetrate biological tissue. Initial reports that introduced this new technology have sparked a vigorous debate on the plausibility of physical mechanisms of ion channel activation by means of external magnetic fields. I argue that the initial criticisms leveled against magnetogenetics as being physically implausible were possibly based on the overly simplistic and unnecessarily pessimistic assumptions about the magnetic spin configurations of iron in ferritin protein. Additionally, all the possible magnetic-field-based mechanisms of ion channel activation in magnetogenetics might not have been fully considered. I present and propose several new magneto-mechanical and magneto-thermal mechanisms of ion channel activation by iron-loaded ferritin protein that may elucidate and clarify some of the mysteries that presently challenge our understanding of the reported biological experiments. Finally, I present some additional puzzles that will require further theoretical and experimental investigation.

The influence of TRPM8 ion channel activation on immune response at different temperature conditions

2012 ◽  
Vol 37 (8) ◽  
pp. 648-653 ◽  
Author(s):  
Tamara V. Kozyreva ◽  
Galina M. Khramova ◽  
Ludmila S. Eliseeva
Keyword(s):  
Immune Response ◽  
Ion Channel ◽  
Channel Activation ◽  
Temperature Conditions

scholarly journals Reduced Graphene Oxides Modulate the Expression of Cell Receptors and Voltage-Dependent Ion Channel Genes of Glioblastoma Multiforme

2021 ◽  
Vol 22 (2) ◽  
pp. 515
Author(s):  
Jaroslaw Szczepaniak ◽  
Joanna Jagiello ◽  
Mateusz Wierzbicki ◽  
Dorota Nowak ◽  
Anna Sobczyk-Guzenda ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Cell Membrane ◽  
Ion Channel ◽  
Functional Groups ◽  
Membrane Damage ◽  
Infrared Analysis ◽  
Graphene Oxides ◽  
Antitumor Effects ◽  
Reduced Graphene ◽  
Voltage Dependent

The development of nanotechnology based on graphene and its derivatives has aroused great scientific interest because of their unusual properties. Graphene (GN) and its derivatives, such as reduced graphene oxide (rGO), exhibit antitumor effects on glioblastoma multiforme (GBM) cells in vitro. The antitumor activity of rGO with different contents of oxygen-containing functional groups and GN was compared. Using FTIR (fourier transform infrared) analysis, the content of individual functional groups (GN/exfoliation (ExF), rGO/thermal (Term), rGO/ammonium thiosulphate (ATS), and rGO/ thiourea dioxide (TUD)) was determined. Cell membrane damage, as well as changes in the cell membrane potential, was analyzed. Additionally, the gene expression of voltage-dependent ion channels (clcn3, clcn6, cacna1b, cacna1d, nalcn, kcne4, kcnj10, and kcnb1) and extracellular receptors was determined. A reduction in the potential of the U87 glioma cell membrane was observed after treatment with rGO/ATS and rGO/TUD flakes. Moreover, it was also demonstrated that major changes in the expression of voltage-dependent ion channel genes were observed in clcn3, nalcn, and kcne4 after treatment with rGO/ATS and rGO/TUD flakes. Furthermore, the GN/ExF, rGO/ATS, and rGO/TUD flakes significantly reduced the expression of extracellular receptors (uPar, CD105) in U87 glioblastoma cells. In conclusion, the cytotoxic mechanism of rGO flakes may depend on the presence and types of oxygen-containing functional groups, which are more abundant in rGO compared to GN.

scholarly journals Measuring the Spatial Arrangement of Nmj-Nachr ion Channel Proteins in the Cell Membrane

2011 ◽  
Vol 100 (3) ◽  
pp. 348a
Author(s):  
Hannah DeBerg ◽  
Nir Friedman ◽  
Cong T. Nguyen ◽  
Paul Simonson ◽  
Paul Selvin
Keyword(s):  
Cell Membrane ◽  
Ion Channel ◽  
Spatial Arrangement ◽  
Channel Proteins ◽  
Ion Channel Proteins

scholarly journals Effect of a static magnetic field on the microscopic characteristics of highly efficient oil-removing bacteria

2017 ◽  
Vol 77 (2) ◽  
pp. 296-303 ◽  
Author(s):  
Zhijun Ren ◽  
Xiaodong Leng ◽  
Qian Liu
Keyword(s):  
Magnetic Field ◽  
Magnetic Fields ◽  
Cell Membrane ◽  
Static Magnetic Field ◽  
Cell Permeability ◽  
Cell Membrane Permeability ◽  
Oil Removal ◽  
Low Intensity ◽  
Highly Efficient ◽  
Acinetobacter Sp

Abstract To better understand the microbial oil removal enhancement process by a magnetic field, the effect of a static magnetic field (SMF) on the microscopic characteristics of highly efficient biodegradation oil-removing bacteria was studied. The Acinetobacter sp. B11 strain with a 53.6% oil removal rate was selected as the reference bacteria. The changes in the microscopic characteristics of Acinetobacter sp. B11 such as the cell surface morphology, cell permeability and cell activity of the bacteria were investigated. The results showed that low-intensity magnetic fields (15–35 mT) improved the ability of Acinetobacter sp. B11 to remove oil by 11.9% at 25 mT compared with that of bacteria with no magnetic field. Without destroying the cell membrane, the low-intensity magnetic fields increased the cell membrane permeability and improved the activity of superoxide dismutase (SOD), which effectively enhanced the oil degradation performance of the bacteria.

scholarly journals Intrinsic concentration cycles and high ion fluxes in self-assembled precipitate membranes

2019 ◽  
Vol 9 (6) ◽  
pp. 20190064 ◽  
Author(s):  
Yang Ding ◽  
Julyan H. E. Cartwright ◽  
Silvana S. S. Cardoso
Keyword(s):  
Cell Membrane ◽  
Fluid Mechanics ◽  
Ion Channel ◽  
Hydrothermal Vents ◽  
Biological Processes ◽  
Biological Cell ◽  
Osmotic Flow ◽  
Building Components ◽  
Self Assembled ◽  
Emergence Of Life

Concentration cycles are important for bonding of basic molecular building components at the emergence of life. We demonstrate that oscillations occur intrinsically in precipitation reactions when coupled with fluid mechanics in self-assembled precipitate membranes, such as at submarine hydrothermal vents. We show that, moreover, the flow of ions across one pore in such a prebiotic membrane is larger than that across one ion channel in a modern biological cell membrane, suggesting that proto-biological processes could be sustained by osmotic flow in a less efficient prebiotic environment. Oscillations in nanoreactors at hydrothermal vents may be just right for these warm little pores to be the cradle of life.

Retracted Article: Microelectrochemical cell arrays for whole-cell currents recording through ion channel proteins based on trans-electroporation approach

The Analyst ◽  
2020 ◽  
Vol 145 (1) ◽  
pp. 197-205 ◽  
Author(s):  
Tianyang Zheng ◽  
Gerhard Baaken ◽  
Jan C. Behrends ◽  
Jürgen Rühe
Keyword(s):  
Cell Membrane ◽  
Ion Channel ◽  
Biological Cell ◽  
Whole Cell ◽  
Channel Proteins ◽  
Retracted Article ◽  
Cell Arrays ◽  
Ion Channel Proteins

A novel chip based method is able to record the whole-cell currents through biological cell membrane with high electrostability.

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