High-resolution vessel wall MRI for the evaluation of intracranial atherosclerotic disease

2017 ◽  
Vol 59 (12) ◽  
pp. 1193-1202 ◽  
Author(s):  
Adam de Havenon ◽  
Mahmud Mossa-Basha ◽  
Lubdha Shah ◽  
Seong-Eun Kim ◽  
Min Park ◽  
...  
Keyword(s):  
High Resolution ◽  
Vessel Wall ◽  
Atherosclerotic Disease ◽  
Intracranial Atherosclerotic Disease

High-Resolution Magnetic Resonance Vessel Wall Imaging in Intracranial Atherosclerotic Disease

2019 ◽  
Vol 1 ◽  
pp. 193-214
Author(s):  
Ramez N. Abdalla ◽  
Donald R. Cantrell ◽  
Alireza Vali ◽  
Michael C. Hurley ◽  
Ali Shaibani ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
High Resolution ◽  
Vessel Wall ◽  
Vessel Wall Imaging ◽  
Atherosclerotic Disease ◽  
Intracranial Atherosclerotic Disease ◽  
Wall Imaging

High resolution vessel wall MR imaging in prestenotic intracranial atherosclerotic disease

2019 ◽  
Vol 63 ◽  
pp. 278-280 ◽  
Author(s):  
Jae W. Song ◽  
Samuel D. Rafla ◽  
Emmanuel C. Obusez ◽  
Scott B. Raymond ◽  
Edip M. Gurol ◽  
...  
Keyword(s):  
High Resolution ◽  
Mr Imaging ◽  
Vessel Wall ◽  
Atherosclerotic Disease ◽  
Intracranial Atherosclerotic Disease

Magnetic resonance vessel wall imaging in intracranial atherosclerotic disease simulating vasculitis

2019 ◽  
Vol 67 (2) ◽  
pp. 588
Author(s):  
PN Sylaja ◽  
K Arun ◽  
Chinmay Nagesh ◽  
C Kesavadas ◽  
SapnaE Sreedharan
Keyword(s):  
Magnetic Resonance ◽  
Vessel Wall ◽  
Vessel Wall Imaging ◽  
Atherosclerotic Disease ◽  
Intracranial Atherosclerotic Disease ◽  
Wall Imaging

Rabbit models of intracranial atherosclerotic disease for pathological validation of vessel wall MRI

2020 ◽  
pp. 197140092098015
Author(s):  
J Scott McNally ◽  
Adam de Havenon ◽  
Seong-Eun Kim ◽  
Chuanzhuo Wang ◽  
Shuping Wang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
New Zealand ◽  
Magnetic Resonance ◽  
Apolipoprotein E ◽  
Sensitivity And Specificity ◽  
Vessel Wall ◽  
Atherosclerotic Disease ◽  
Resonance Imaging ◽  
Intracranial Atherosclerotic Disease ◽  
Human Pathology

Introduction Vessel wall magnetic resonance imaging can improve the evaluation of intracranial atherosclerotic disease. However, pathological validation is needed to improve vessel wall magnetic resonance imaging techniques. Human pathology samples are not practical for such analysis, so an animal model is therefore needed. Materials and methods Watanabe heritable hyperlipidemic rabbits and apolipoprotein E knockout rabbits were evaluated against New Zealand white wild-type rabbits. Evaluation of intracranial arteries was performed with vessel wall magnetic resonance imaging and pathological analysis, rating the presence and severity of disease in each segment. Two-tailed t-tests were performed to compare disease occurrence and severity prevalence among rabbit subtypes. Sensitivity and specificity were calculated to assess the diagnostic accuracy of vessel wall magnetic resonance imaging. Results Seventeen rabbits (five Watanabe heritable hyperlipidemic, four apolipoprotein E knockout and eight New Zealand white) were analysed for a total of 51 artery segments. Eleven segments (five Watanabe heritable hyperlipidemic and six apolipoprotein E knockout) demonstrated intracranial atherosclerotic disease on pathology. Disease model animals had lesions more frequently than New Zealand white animals ( P<0.001). The sensitivity and specificity of vessel wall magnetic resonance imaging for the detection of intracranial atherosclerotic disease were 68.8% and 95.2%, respectively. When excluding mild cases to assess vessel wall magnetic resonance imaging accuracy for detecting moderate to severe intracranial atherosclerotic disease lesions, sensitivity improved to 100% with unchanged specificity. Conclusion Intracranial atherosclerotic disease can be reliably produced and detected using 3T vessel wall magnetic resonance imaging-compatible Watanabe heritable hyperlipidemic and ApoE rabbit models. Further analysis is needed to characterize better the development and progression of the disease to correlate tissue-validated animal findings with those in human vessel wall magnetic resonance imaging studies.

scholarly journals Development of a high resolution MRI intracranial atherosclerosis imaging phantom

2017 ◽  
Vol 10 (2) ◽  
pp. 143-149 ◽  
Author(s):  
Ju-Yu Chueh ◽  
Kajo van der Marel ◽  
Matthew J Gounis ◽  
Todd LeMatty ◽  
Truman R Brown ◽  
...  
Keyword(s):  
High Resolution ◽  
Vessel Wall ◽  
Cone Beam Ct ◽  
Absolute Difference ◽  
Patient Specific ◽  
Fibrous Cap ◽  
Intracranial Atherosclerotic Disease ◽  
High Resolution Mri ◽  
Atherosclerosis Imaging ◽  
Stenotic Vessel

Background and purposeCurrently, there is neither a standard protocol for vessel wall MR imaging of intracranial atherosclerotic disease (ICAD) nor a gold standard phantom to compare MR sequences. In this study, a plaque phantom is developed and characterized that provides a platform for establishing a uniform imaging approach for ICAD.Materials and methodsA patient specific injection mold was 3D printed to construct a geometrically accurate ICAD phantom. Polyvinyl alcohol hydrogel was infused into the core shell mold to form the stenotic artery. The ICAD phantom incorporated materials mimicking a stenotic vessel and plaque components, including fibrous cap and lipid core. Two phantoms were scanned using high resolution cone beam CT and compared with four different 3 T MRI systems across eight different sites over a period of 18 months. Inter-phantom variability was assessed by lumen dimensions and contrast to noise ratio (CNR).ResultsQuantitative evaluation of the minimum lumen radius in the stenosis showed that the radius was on average 0.80 mm (95% CI 0.77 to 0.82 mm) in model 1 and 0.77 mm (95% CI 0.74 to 0.81 mm) in model 2. The highest CNRs were observed for comparisons between lipid and vessel wall. To evaluate manufacturing reproducibility, the CNR variability between the two models had an average absolute difference of 4.31 (95% CI 3.82 to 5.78). Variation in CNR between the images from the same scanner separated by 7 months was 2.5–6.2, showing reproducible phantom durability.ConclusionsA plaque phantom composed of a stenotic vessel wall and plaque components was successfully constructed for multicenter high resolution MRI standardization.

Disparate trends of atherosclerotic plaque evolution in stroke patients under 18-month follow-up: a 3D whole-brain magnetic resonance vessel wall imaging study

2021 ◽  
pp. 197140092110269
Author(s):  
Jiayu Xiao ◽  
Shlee S Song ◽  
Konrad H Schlick ◽  
Shuang Xia ◽  
Tao Jiang ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Vessel Wall ◽  
Morphological Changes ◽  
Contrast Ratio ◽  
Vessel Wall Imaging ◽  
Atherosclerotic Disease ◽  
Stroke Recurrence ◽  
Intracranial Atherosclerotic Disease ◽  
Maximum Wall Thickness ◽  
Wall Imaging

Purpose The trend of atherosclerotic plaque feature evolution is unclear in stroke patients with and without recurrence. We aimed to use three-dimensional whole-brain magnetic resonance vessel wall imaging to quantify the morphological changes of causative lesions during medical therapy in patients with symptomatic intracranial atherosclerotic disease. Methods Patients with acute ischemic stroke attributed to intracranial atherosclerotic disease were retrospectively enrolled if they underwent both baseline and follow-up magnetic resonance vessel wall imaging. The morphological features of the causative plaque, including plaque volume, peak normalized wall index, maximum wall thickness, degree of stenosis, pre-contrast plaque-wall contrast ratio, and post-contrast plaque enhancement ratio, were quantified and compared between the non-recurrent and recurrent groups (defined as the recurrence of a vascular event within 18 months of stroke). Results Twenty-nine patients were included in the final analysis. No significant differences were found in plaque features in the baseline scan between the non-recurrent ( n = 22) and recurrent groups ( n = 7). The changes in maximum wall thickness (–13.32% vs. 8.93%, P = 0.026), plaque-wall contrast ratio (–0.82% vs. 3.42%, P = 0.005) and plaque enhancement ratio (–11.03% vs. 9.75%, P = 0.019) were significantly different between the non-recurrent and recurrent groups. Univariable logistic regression showed that the increase in plaque-wall contrast ratio (odds ratio 3.22, 95% confidence interval 1.55–9.98, P = 0.003) was related to stroke recurrence. Conclusion Morphological changes of plaque features on magnetic resonance vessel wall imaging demonstrated distinct trends in symptomatic intracranial atherosclerotic disease patients with and without stroke recurrence.

scholarly journals Whole-brain magnetic resonance imaging of plaque burden and lenticulostriate arteries in patients with different types of stroke

2019 ◽  
Vol 12 ◽  
pp. 175628641983329 ◽  
Author(s):  
Fang Wu ◽  
Qian Zhang ◽  
Kai Dong ◽  
Jiangang Duan ◽  
Xiaoxu Yang ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Vessel Wall ◽  
Imaging Techniques ◽  
Three Dimensional ◽  
Brain Magnetic Resonance Imaging ◽  
Atherosclerotic Disease ◽  
Plaque Burden ◽  
Control Group ◽  
Whole Brain ◽  
Intracranial Atherosclerotic Disease

Background: Large-vessel atherosclerotic disease is an important pathogenesis of deep-perforator infarction (DPI). However, altered vessel walls of intracranial large arteries and distribution of small arteries in DPI are unclear because of the limited resolution of current imaging techniques. In this study the intracranial plaque burden and lenticulostriate artery (LSA) distribution in patients with recent DPI and non-DPI using whole-brain vessel-wall imaging (WB-VWI) were investigated. Methods: A total of 44 patients with recent DPI (23 patients) or non-DPI (21 patients) due to intracranial atherosclerotic disease were prospectively enrolled. WB-VWI was performed in all the patients using a three-dimensional T1-weighted vessel-wall magnetic resonance technique. Hemispheres with DPI and non-DPI were considered as the DPI group and non-DPI group, respectively. Hemispheres without a history of stroke were the control group. The intracranial plaque burden was compared between the DPI and non-DPI groups. The number and length of visualized LSA branches among DPI, non-DPI, and control groups were also evaluated. Results: A total of 77 hemispheres were analyzed (23 in the DPI group, 21 in the non-DPI group, and 33 in the control group). Plaque burden was lower ( p = 0.047) in the DPI group (82.0 ± 45.9 mm3) compared with the non-DPI group (130.9 ± 90.3 mm3). There was a significant reduction ( p = 0.002) in length of visualized LSA branches in the DPI group (74.1 ± 21.7 mm) compared with the control group (104.6 ± 33.3 mm). Conclusions: WB-VWI enables the combination of vessel-wall and LSA imaging in one image setting, which can provide information about plaque burden and LSA distribution.

scholarly journals High-Resolution MRI of Intracranial Atherosclerotic Disease

2014 ◽  
Vol 9 (1) ◽  
pp. 9 ◽  
Author(s):  
Chang-Woo Ryu ◽  
Hyo-Sung Kwak ◽  
Geon-Ho Jahng ◽  
Han Na Lee
Keyword(s):  
High Resolution ◽  
Atherosclerotic Disease ◽  
Intracranial Atherosclerotic Disease ◽  
High Resolution Mri
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