Plaque Morphologic Quantification Reliability of 3D Whole‐Brain Vessel Wall Imaging in Patients With Intracranial Atherosclerotic Disease: A Comparison With Conventional 3D Targeted Vessel Wall Imaging

2021 ◽  
Author(s):  
Na Zhang ◽  
Xinfeng Liu ◽  
Jiayu Xiao ◽  
Shlee S. Song ◽  
Zhaoyang Fan
Keyword(s):  
Vessel Wall ◽  
Vessel Wall Imaging ◽  
Atherosclerotic Disease ◽  
Whole Brain ◽  
Intracranial Atherosclerotic Disease ◽  
Brain Vessel ◽  
Wall Imaging

Magnetic resonance vessel wall imaging in intracranial atherosclerotic disease simulating vasculitis

2019 ◽  
Vol 67 (2) ◽  
pp. 588
Author(s):  
PN Sylaja ◽  
K Arun ◽  
Chinmay Nagesh ◽  
C Kesavadas ◽  
SapnaE Sreedharan
Keyword(s):  
Magnetic Resonance ◽  
Vessel Wall ◽  
Vessel Wall Imaging ◽  
Atherosclerotic Disease ◽  
Intracranial Atherosclerotic Disease ◽  
Wall Imaging

High-Resolution Magnetic Resonance Vessel Wall Imaging in Intracranial Atherosclerotic Disease

2019 ◽  
Vol 1 ◽  
pp. 193-214
Author(s):  
Ramez N. Abdalla ◽  
Donald R. Cantrell ◽  
Alireza Vali ◽  
Michael C. Hurley ◽  
Ali Shaibani ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
High Resolution ◽  
Vessel Wall ◽  
Vessel Wall Imaging ◽  
Atherosclerotic Disease ◽  
Intracranial Atherosclerotic Disease ◽  
Wall Imaging

Disparate trends of atherosclerotic plaque evolution in stroke patients under 18-month follow-up: a 3D whole-brain magnetic resonance vessel wall imaging study

2021 ◽  
pp. 197140092110269
Author(s):  
Jiayu Xiao ◽  
Shlee S Song ◽  
Konrad H Schlick ◽  
Shuang Xia ◽  
Tao Jiang ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Vessel Wall ◽  
Morphological Changes ◽  
Contrast Ratio ◽  
Vessel Wall Imaging ◽  
Atherosclerotic Disease ◽  
Stroke Recurrence ◽  
Intracranial Atherosclerotic Disease ◽  
Maximum Wall Thickness ◽  
Wall Imaging

Purpose The trend of atherosclerotic plaque feature evolution is unclear in stroke patients with and without recurrence. We aimed to use three-dimensional whole-brain magnetic resonance vessel wall imaging to quantify the morphological changes of causative lesions during medical therapy in patients with symptomatic intracranial atherosclerotic disease. Methods Patients with acute ischemic stroke attributed to intracranial atherosclerotic disease were retrospectively enrolled if they underwent both baseline and follow-up magnetic resonance vessel wall imaging. The morphological features of the causative plaque, including plaque volume, peak normalized wall index, maximum wall thickness, degree of stenosis, pre-contrast plaque-wall contrast ratio, and post-contrast plaque enhancement ratio, were quantified and compared between the non-recurrent and recurrent groups (defined as the recurrence of a vascular event within 18 months of stroke). Results Twenty-nine patients were included in the final analysis. No significant differences were found in plaque features in the baseline scan between the non-recurrent ( n = 22) and recurrent groups ( n = 7). The changes in maximum wall thickness (–13.32% vs. 8.93%, P = 0.026), plaque-wall contrast ratio (–0.82% vs. 3.42%, P = 0.005) and plaque enhancement ratio (–11.03% vs. 9.75%, P = 0.019) were significantly different between the non-recurrent and recurrent groups. Univariable logistic regression showed that the increase in plaque-wall contrast ratio (odds ratio 3.22, 95% confidence interval 1.55–9.98, P = 0.003) was related to stroke recurrence. Conclusion Morphological changes of plaque features on magnetic resonance vessel wall imaging demonstrated distinct trends in symptomatic intracranial atherosclerotic disease patients with and without stroke recurrence.

Multi-sequence whole-brain intracranial vessel wall imaging at 7.0 tesla

2013 ◽  
Vol 23 (11) ◽  
pp. 2996-3004 ◽  
Author(s):  
Anja G. van der Kolk ◽  
Jeroen Hendrikse ◽  
Manon Brundel ◽  
Geert J. Biessels ◽  
Ewoud J. Smit ◽  
...  
Keyword(s):  
Vessel Wall ◽  
Vessel Wall Imaging ◽  
Whole Brain ◽  
Intracranial Vessel ◽  
Wall Imaging

scholarly journals T2-Weighted Whole-Brain Intracranial Vessel Wall Imaging at 3 Tesla With Cerebrospinal Fluid Suppression

2021 ◽  
Vol 15 ◽  
Author(s):  
Lei Zhang ◽  
Yanjie Zhu ◽  
Yulong Qi ◽  
Liwen Wan ◽  
Lijie Ren ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Vessel Wall ◽  
Vessel Wall Imaging ◽  
Inversion Recovery ◽  
Whole Brain ◽  
Intracranial Vessel ◽  
Spin Echo Sequence ◽  
Weighted Sequences ◽  
Preparation Module ◽  
Wall Imaging

BackgroundT2-weighted (T2w) intracranial vessel wall imaging (IVWI) provides good contrast to differentiate intracranial vasculopathies and discriminate various important plaque components. However, the strong cerebrospinal fluid (CSF) signal in T2w images interferes with depicting the intracranial vessel wall. In this study, we propose a T2-prepared sequence for whole-brain IVWI at 3T with CSF suppression.MethodsA preparation module that combines T2 preparation and inversion recovery (T2IR) was used to suppress the CSF signal and was incorporated into the commercial three-dimensional (3D) turbo spin echo sequence-Sampling Perfection with Application optimized Contrast using different flip angle Evolution (SPACE). This new technique (hereafter called T2IR-SPACE) was evaluated on nine healthy volunteers and compared with two other commonly used 3D T2-weighted sequences: T2w-SPACE and FLAIR-SPACE (FLAIR: fluid-attenuated inversion recovery). The signal-to-noise ratios (SNRs) of the vessel wall (VW) and CSF and contrast-to-noise ratios (CNRs) between them were measured and compared among these three T2-weighted sequences. Subjective wall visualization of the three T2-weighted sequences was scored blindly and independently by two radiologists using a four-point scale followed by inter-rater reproducibility analysis. A pilot study of four stroke patients was performed to preliminarily evaluate the diagnostic value of this new sequence, which was compared with two conventional T2-weighted sequences.ResultsT2IR-SPACE had the highest CNR (11.01 ± 6.75) compared with FLAIR-SPACE (4.49 ± 3.15; p < 0.001) and T2w-SPACE (−56.16 ± 18.58; p < 0.001). The subjective wall visualization score of T2IR-SPACE was higher than those of FLAIR-SPACE and T2w-SPACE (T2IR-SPACE: 2.35 ± 0.59; FLAIR-SPACE: 0.52 ± 0.54; T2w-SPACE: 1.67 ± 0.58); the two radiologists’ scores showed excellent agreement (ICC = 0.883).ConclusionThe T2IR preparation module markedly suppressed the CSF signal without much SNR loss of the other tissues (i.e., vessel wall, white matter, and gray matter) compared with the IR pulse. Our results suggest that T2IR-SPACE is a potential alternative T2-weighted sequence for assessing intracranial vascular diseases.

scholarly journals Whole-brain magnetic resonance imaging of plaque burden and lenticulostriate arteries in patients with different types of stroke

2019 ◽  
Vol 12 ◽  
pp. 175628641983329 ◽  
Author(s):  
Fang Wu ◽  
Qian Zhang ◽  
Kai Dong ◽  
Jiangang Duan ◽  
Xiaoxu Yang ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Vessel Wall ◽  
Imaging Techniques ◽  
Three Dimensional ◽  
Brain Magnetic Resonance Imaging ◽  
Atherosclerotic Disease ◽  
Plaque Burden ◽  
Control Group ◽  
Whole Brain ◽  
Intracranial Atherosclerotic Disease

Background: Large-vessel atherosclerotic disease is an important pathogenesis of deep-perforator infarction (DPI). However, altered vessel walls of intracranial large arteries and distribution of small arteries in DPI are unclear because of the limited resolution of current imaging techniques. In this study the intracranial plaque burden and lenticulostriate artery (LSA) distribution in patients with recent DPI and non-DPI using whole-brain vessel-wall imaging (WB-VWI) were investigated. Methods: A total of 44 patients with recent DPI (23 patients) or non-DPI (21 patients) due to intracranial atherosclerotic disease were prospectively enrolled. WB-VWI was performed in all the patients using a three-dimensional T1-weighted vessel-wall magnetic resonance technique. Hemispheres with DPI and non-DPI were considered as the DPI group and non-DPI group, respectively. Hemispheres without a history of stroke were the control group. The intracranial plaque burden was compared between the DPI and non-DPI groups. The number and length of visualized LSA branches among DPI, non-DPI, and control groups were also evaluated. Results: A total of 77 hemispheres were analyzed (23 in the DPI group, 21 in the non-DPI group, and 33 in the control group). Plaque burden was lower ( p = 0.047) in the DPI group (82.0 ± 45.9 mm3) compared with the non-DPI group (130.9 ± 90.3 mm3). There was a significant reduction ( p = 0.002) in length of visualized LSA branches in the DPI group (74.1 ± 21.7 mm) compared with the control group (104.6 ± 33.3 mm). Conclusions: WB-VWI enables the combination of vessel-wall and LSA imaging in one image setting, which can provide information about plaque burden and LSA distribution.

Abstract 48: High-Resolution Vessel Wall Imaging of Cryptogenic Stroke: A 7T MRI Study

Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Jorge A Roa ◽  
Mario Zanaty ◽  
Daizo Ishii ◽  
Colin P Derdeyn ◽  
Girish Bathla ◽  
...  
Keyword(s):  
High Resolution ◽  
Vessel Wall ◽  
Cryptogenic Stroke ◽  
Vessel Wall Imaging ◽  
Observer Agreement ◽  
Intraplaque Hemorrhage ◽  
Post Contrast ◽  
Intracranial Atherosclerotic Disease ◽  
Wall Imaging

Background: High-resolution vessel wall imaging (HR-VWI) has emerged as a useful tool for characterization of intracranial vasculopathic processes. HR-VWI allows better characterization of the arterial wall and may aid in the identification of atherosclerotic plaques, intra-arterial hemorrhages such as in the case of dissections and/or increased contrast enhancement such as in vasculitis. 7T HR-VWI may provide additional information in the identification of stroke mechanism in patients with cryptogenic stroke. Methods: Patients with cryptogenic stroke were prospectively imaged with a 7T scan. Strokes were determined to be cryptogenic after an extensive diagnostic work-up was completed. T1-weighted (pre- and post-contrast), T2-weighted, TOF and SWAN sequences were obtained. Demographic and clinical information was gathered from electronic medical charts. Results: Seventeen patients were included. Mean age was 57.8 ± 16.3 years-old, and 10 (58.8%) were women. HR-VWI determined the etiology of AIS in all subjects: 12 (70.6%) intracranial atherosclerotic disease (ICAD), 3 small-vessel disease and 2 arterial dissections. Inter-observer agreement was κ = 0.92. Plaque enhancement was identified in 14 cases, and intraplaque hemorrhage in 1 case of arterial dissection. In a patient with angiography suggestive of Moyamoya disease, HR-VWI determined the presence of diffuse ICAD as the underlying cause of stroke. Conclusion: HR-VWI may be used in patients with cryptogenic stroke to identify the etiologic mechanism and guide treatment. Figure: Axial-DWI (A) shows an acute right-medullary infarct (arrow). (B) Right-VA stenosis (arrow) on CTA. 7T axial-SWAN (C) reveals focal-susceptibility (arrowhead) and intra-vessel hemosiderin (arrow) suggestive of IPH. Axial-T1 pre-contrast (D), post-contrast (E) and sagittal MPR (F) images show eccentric thickening/enhancement of right-VA (arrowheads), compared to normal-appearing left-VA (arrows D-E).

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