Abstract TMP52: Association of Chronic Kidney Disease and Intracranial Atherosclerotic Disease by High Resolution Vessel Wall MRI: The ARIC Study

Stroke ◽  
2018 ◽  
Vol 49 (Suppl_1) ◽  
Author(s):  
Qing HAO ◽  
Rebecca Gottesman ◽  
Ye Qiao ◽  
Richa Sharma ◽  
Li Liu ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
High Resolution ◽  
Kidney Disease ◽  
Vessel Wall ◽  
Atherosclerotic Disease ◽  
Intracranial Atherosclerotic Disease ◽  
Aric Study

High-Resolution Magnetic Resonance Vessel Wall Imaging in Intracranial Atherosclerotic Disease

2019 ◽  
Vol 1 ◽  
pp. 193-214
Author(s):  
Ramez N. Abdalla ◽  
Donald R. Cantrell ◽  
Alireza Vali ◽  
Michael C. Hurley ◽  
Ali Shaibani ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
High Resolution ◽  
Vessel Wall ◽  
Vessel Wall Imaging ◽  
Atherosclerotic Disease ◽  
Intracranial Atherosclerotic Disease ◽  
Wall Imaging

High resolution vessel wall MR imaging in prestenotic intracranial atherosclerotic disease

2019 ◽  
Vol 63 ◽  
pp. 278-280 ◽  
Author(s):  
Jae W. Song ◽  
Samuel D. Rafla ◽  
Emmanuel C. Obusez ◽  
Scott B. Raymond ◽  
Edip M. Gurol ◽  
...  
Keyword(s):  
High Resolution ◽  
Mr Imaging ◽  
Vessel Wall ◽  
Atherosclerotic Disease ◽  
Intracranial Atherosclerotic Disease

High-resolution vessel wall MRI for the evaluation of intracranial atherosclerotic disease

2017 ◽  
Vol 59 (12) ◽  
pp. 1193-1202 ◽  
Author(s):  
Adam de Havenon ◽  
Mahmud Mossa-Basha ◽  
Lubdha Shah ◽  
Seong-Eun Kim ◽  
Min Park ◽  
...  
Keyword(s):  
High Resolution ◽  
Vessel Wall ◽  
Atherosclerotic Disease ◽  
Intracranial Atherosclerotic Disease

scholarly journals Biomarker Profiling of Neurovascular Diseases in Patients with Stage 5 Chronic Kidney Disease

2018 ◽  
Vol 24 (9_suppl) ◽  
pp. 248S-254S
Author(s):  
Justin Lee ◽  
Jack Bontekoe ◽  
Brandon Trac ◽  
Vinod Bansal ◽  
José Biller ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Carotid Artery Disease ◽  
Vascular Dysfunction ◽  
Enzyme Linked Immunosorbent Assay ◽  
Neurocognitive Deficits ◽  
Intracranial Atherosclerotic Disease ◽  
Artery Disease ◽  
D Dimer ◽  
Neurovascular Diseases

Patients with stage 5 chronic kidney disease (CKD5D) have a higher risk of developing neurocognitive deficits. Stroke, cervical carotid artery disease (CCAD), and intracranial atherosclerotic disease (ICAD) are causes of such deficits in CKD5D. Chronic inflammation from renal failure elevates risk for these diseases through oxidative stress and vascular dysfunction. The adverse impact on the carotid and intracranial vasculatures contributes to the multifactorial pathophysiology of stroke. Eleven plasma biomarker levels in patients with CKD5D (n = 97) and healthy controls (n = 17-50) were measured using sandwich enzyme-linked immunosorbent assay (ELISA) method. Of the 97 patients with CKD5D, 24 had CCAD, 19 had ICAD, and 23 had acute stroke. Elevations in NACHT, LRR, and PYD domains-containing protein 3 (NALP3) levels in patients with CKD5D (+)CCAD (1.80 ± 0.11 ng/mL) compared to patients with (−)CCAD (1.55 ± 0.08 ng/mL) were statistically significant ( P = .0299). Differences in D-dimer levels were also found to be statistically significant ( P = .0258) between CKD5D (+)stroke (1.83 ± 0.42 μg/mL) and (−)stroke (0.89 ± 0.13 μg/mL) groups. The ages of the (+) neurovascular disease groups were found to be significantly elevated compared to the (−) neurovascular disease groups ( P = .0002 carotid AD; P < .0001 ICAD; P = .0157 stroke). D-dimer levels were positively correlated with age in CKD5D ( P = .0375). With the possible exception of NALP3 for CCAD, profiling levels of specific biomarkers for risk stratification of neurovascular diseases in the CKD5D population warrants further investigation.

scholarly journals Circulating Biomarker Levels in Patients With Stage 5 Chronic Kidney Disease With Respect to Neurovascular Diseases

2018 ◽  
Vol 24 (9_suppl) ◽  
pp. 314S-322S
Author(s):  
Justin Lee ◽  
Ryan McMillan ◽  
Leonidas Skiadopoulos ◽  
Vinod Bansal ◽  
José Biller ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Carotid Artery Disease ◽  
Kidney Injury ◽  
Assay Method ◽  
Neurocognitive Deficits ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Intracranial Atherosclerotic Disease ◽  
Artery Disease ◽  
Kidney Injury Molecule 1

The prevalence of neurocognitive deficits remains high in patients with stage 5 chronic kidney disease (CKD5D). Major contributors to such deficits include stroke, cervical carotid artery disease (CCAD), and intracranial atherosclerotic disease (ICAD). The risk of developing these dysfunctional vascular processes is facilitated by the chronic inflammation associated with renal failure. Plasma levels of 10 circulating biomarkers in patients with CKD5D (n = 78-90) were quantified using the sandwich enzyme linked immune sorbent assay method. Biomarkers for this study included kidney injury molecule-1, N-terminal prohormone of brain natriuretic peptide (NT-proBNP), neutrophil gelatinase-associated lipocalin, interleukin-18, endothelin 1, calcifediol, parathyroid hormone, platelet-derived growth factor, microparticles-expressing tissue factor, and lipoprotein(a) (Lp(a)). Of the 90 patients with CKD5D, 30 had CCAD, 24 had ICAD, and 22 had stroke. Lp(a) level was significantly elevated in patients with CKD5D with comorbid ICAD compared to those without (125.70 ± 10.03 ng/mL vs 97.16 ± 5.97 ng/mL; P = .0065). NT-proBNP level was also significantly elevated in patients with CKD5D with comorbid stroke diagnosis compared to those without stroke history, once patients with a diagnosis of heart failure (HF) were excluded (14.84 ± 2.80 ng/mL vs 9.06 ± 1.27 ng/mL; P = .0283). Profiling levels of Lp(a) and NT-ProBNP could thus be useful in the risk stratification of ICAD and stroke, respectively, in the CKD5D population.

Magnetic resonance vessel wall imaging in intracranial atherosclerotic disease simulating vasculitis

2019 ◽  
Vol 67 (2) ◽  
pp. 588
Author(s):  
PN Sylaja ◽  
K Arun ◽  
Chinmay Nagesh ◽  
C Kesavadas ◽  
SapnaE Sreedharan
Keyword(s):  
Magnetic Resonance ◽  
Vessel Wall ◽  
Vessel Wall Imaging ◽  
Atherosclerotic Disease ◽  
Intracranial Atherosclerotic Disease ◽  
Wall Imaging

Rabbit models of intracranial atherosclerotic disease for pathological validation of vessel wall MRI

2020 ◽  
pp. 197140092098015
Author(s):  
J Scott McNally ◽  
Adam de Havenon ◽  
Seong-Eun Kim ◽  
Chuanzhuo Wang ◽  
Shuping Wang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
New Zealand ◽  
Magnetic Resonance ◽  
Apolipoprotein E ◽  
Sensitivity And Specificity ◽  
Vessel Wall ◽  
Atherosclerotic Disease ◽  
Resonance Imaging ◽  
Intracranial Atherosclerotic Disease ◽  
Human Pathology

Introduction Vessel wall magnetic resonance imaging can improve the evaluation of intracranial atherosclerotic disease. However, pathological validation is needed to improve vessel wall magnetic resonance imaging techniques. Human pathology samples are not practical for such analysis, so an animal model is therefore needed. Materials and methods Watanabe heritable hyperlipidemic rabbits and apolipoprotein E knockout rabbits were evaluated against New Zealand white wild-type rabbits. Evaluation of intracranial arteries was performed with vessel wall magnetic resonance imaging and pathological analysis, rating the presence and severity of disease in each segment. Two-tailed t-tests were performed to compare disease occurrence and severity prevalence among rabbit subtypes. Sensitivity and specificity were calculated to assess the diagnostic accuracy of vessel wall magnetic resonance imaging. Results Seventeen rabbits (five Watanabe heritable hyperlipidemic, four apolipoprotein E knockout and eight New Zealand white) were analysed for a total of 51 artery segments. Eleven segments (five Watanabe heritable hyperlipidemic and six apolipoprotein E knockout) demonstrated intracranial atherosclerotic disease on pathology. Disease model animals had lesions more frequently than New Zealand white animals ( P<0.001). The sensitivity and specificity of vessel wall magnetic resonance imaging for the detection of intracranial atherosclerotic disease were 68.8% and 95.2%, respectively. When excluding mild cases to assess vessel wall magnetic resonance imaging accuracy for detecting moderate to severe intracranial atherosclerotic disease lesions, sensitivity improved to 100% with unchanged specificity. Conclusion Intracranial atherosclerotic disease can be reliably produced and detected using 3T vessel wall magnetic resonance imaging-compatible Watanabe heritable hyperlipidemic and ApoE rabbit models. Further analysis is needed to characterize better the development and progression of the disease to correlate tissue-validated animal findings with those in human vessel wall magnetic resonance imaging studies.

An Overview of the Pathophysiology of Vascular Calcification in Chronic Kidney Disease

2007 ◽  
Vol 27 (2_suppl) ◽  
pp. 215-222 ◽  
Author(s):  
Tomasz Stompór
Keyword(s):  
Chronic Kidney Disease ◽  
Calcium Phosphate ◽  
Kidney Disease ◽  
Vascular Calcification ◽  
Vessel Wall ◽  
Matrix Gla Protein ◽  
Soft Tissue Calcification ◽  
Poor Control ◽  
Bone Morphogenetic Protein 7 ◽  
Morphogenetic Protein

Abnormalities of calcium–phosphate balance, with subsequent bone metabolism disorders, are among the key and earliest features of chronic kidney disease (CKD). Recently, another consequence of these abnormalities was brought to light—namely, vascular calcification. Most studies performed in patients on dialysis suggest that their vascular calcification is more advanced than that seen in the general population. Furthermore, the progression of vessel wall mineralization is much more dynamic in patients with CKD. Apart from the commonly assessed factors that promote vascular calcification, such as age, duration of dialysis, or poor control of calcium–phosphate status, several other factors have recently been identified. In the spectrum of substances involved in the regulation of the process of soft-tissue calcification, the most extensively studied in the nephrology literature are bone morphogenetic protein 7, osteoprotegerin, matrix Gla protein, fetuin-A, and the phosphatonins. Better understanding of the mechanisms underlying excess vascular mineralization have led to the development of promising new therapies.

Bone Imaging and Chronic Kidney Disease: Will High-Resolution Peripheral Tomography Improve Bone Evaluation and Therapeutic Management?

2009 ◽  
Vol 19 (1) ◽  
pp. 44-49 ◽  
Author(s):  
Justine Bacchetta ◽  
Stéphanie Boutroy ◽  
Laurent Juillard ◽  
Nicolas Vilayphiou ◽  
Fitsum Guebre-Egziabher ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
High Resolution ◽  
Kidney Disease ◽  
Therapeutic Management ◽  
Bone Imaging
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