Plastic membrane electrode for the potentiometric determination of pethidine hydrochloride in pharmaceutical preparations

2000 ◽  
Vol 368 (4) ◽  
pp. 335-337 ◽  
Author(s):  
Z.-H. Liu ◽  
M.-L. Wen ◽  
Y. Yao ◽  
J. Xiong
Keyword(s):  
Pharmaceutical Preparations ◽  
Potentiometric Determination ◽  
Membrane Electrode ◽  
Plastic Membrane

Plastic membrane electrode for selective determination of diclofenac (voltaren) in pharmaceutical preparations

The Analyst ◽  
1994 ◽  
Vol 119 (9) ◽  
pp. 1993 ◽  
Author(s):  
Saad S. M. Hassan ◽  
Ragab M. Abdel-Aziz ◽  
Mohamed S. Abdel-Samad
Keyword(s):  
Pharmaceutical Preparations ◽  
Membrane Electrode ◽  
Selective Determination ◽  
Plastic Membrane

scholarly journals Construction and Evaluation of Scopolamine Ion- Selective Electrode

2000 ◽  
Vol 68 (3) ◽  
pp. 247-261
Author(s):  
A. Shalaby ◽  
M. El-Maamly ◽  
H. Abdellatef
Keyword(s):  
Pharmaceutical Preparations ◽  
Electrode System ◽  
Potentiometric Determination ◽  
Membrane Electrode ◽  
Selective Membrane ◽  
Nernstian Slope ◽  
Ion Associate ◽  
Ph Range ◽  
Associate Species

The construction of plasticised PVC matrix-type scopolamine ion- selective membrane electrode and its use in the potentiometric determination of scopolamine in pharmaceutical preparations are described. It is based on the use of tlie ion-associate species, fonned by scopolainine cation and 5-nitrobarbitoric counter ion. The basic electrode peifonnance characteristics are evaluated according to IUPAC I-ecoininendatioiis. It exhibited a linear response for 1x10-2–1x10-5 M of scopolamine solutions with a cationic Nernstian slope over the pH range of 4-7. Common organic and inorganic cations showed negligible interference. Direct potentiometric determination of 1x10-2–1x10-5 M aqueous tubocurarine chloride using this membrane electrode system showed an average recovery of 99.05 with a mean standard deviation of 0.12. This electrode system was successfully applied to the potentiometric determination of scopolamine in some pharmaceutical preparations.

Spectrophotometric and Potentiometric Determination of Piroxicam and Tenoxicam in Pharmaceutical Preparations

2003 ◽  
Vol 51 (1) ◽  
pp. 6-10 ◽  
Author(s):  
Mohamed A. El-Ries ◽  
Gehad Mohamed ◽  
Shaeban Khalil ◽  
Manal El-Shall
Keyword(s):  
Pharmaceutical Preparations ◽  
Potentiometric Determination

scholarly journals Potentiometric Determination of Ketotifen Fumarate in Pharmaceutical Preparations and Urine Using Carbon Paste and PVC Membrane Selective Electrodes

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Eman Y. Z. Frag ◽  
Gehad G. Mohamed ◽  
Mohamed M. Khalil ◽  
Mohammad M. A. Hwehy
Keyword(s):  
Biological Fluid ◽  
Pharmaceutical Preparations ◽  
Standard Addition ◽  
Selectivity Coefficient ◽  
Potentiometric Determination ◽  
Pvc Membrane ◽  
Membrane Electrodes ◽  
Carbon Paste ◽  
Ketotifen Fumarate

This study compares between unmodified carbon paste (CPE; the paste has no ion pair) and polyvinyl chloride (PVC) membrane selective electrodes that were used in potentiometric determination of ketotifen fumarate (KTF), where sodium tetraphenylborate (NaTPB) was used as titrant. The performance characteristics of these sensors were evaluated according to IUPAC recommendations which reveal a fast, stable, and linear response for KTF over the concentration range of 10−7to 10−2 mol L−1. The electrodes show Nernstian slope value of and  mV decade−1for CPE and PVC membrane electrodes at 30∘C, respectively. The potential is nearly stable over the pH range 3.0–6.0 and 2.0–7.0 for CPE and PVC membrane electrodes, respectively. Selectivity coefficient values towards different inorganic cations, sugars, and amino acids reflect high selectivity of the prepared electrodes. The electrodes responses at different temperatures were also studied, and long operational lifetime of 12 and 5 weeks for CPE and PVC membrane electrodes, respectively, were found. These are used for determination of ketotifen fumarate using potentiometric titration, calibration, and standard addition methods in pure samples, its pharmaceutical preparations (Zaditen tablets), and biological fluid (urine). The direct potentiometric determination of KTF using the proposed sensors gave recoveries % of and with RSD 1.42 and 0.63% for CPE and PVC membrane selective electrodes, respectively. Validation of the method shows suitability of the proposed sensors for use in quality control assessment of KTF. The obtained results were in a good agreement with those obtained using the reported spectrophotometric method.

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