Spectrophotometric and Potentiometric Determination of Piroxicam and Tenoxicam in Pharmaceutical Preparations

2003 ◽  
Vol 51 (1) ◽  
pp. 6-10 ◽  
Author(s):  
Mohamed A. El-Ries ◽  
Gehad Mohamed ◽  
Shaeban Khalil ◽  
Manal El-Shall
Keyword(s):  
Pharmaceutical Preparations ◽  
Potentiometric Determination

scholarly journals Potentiometric Determination of Ketotifen Fumarate in Pharmaceutical Preparations and Urine Using Carbon Paste and PVC Membrane Selective Electrodes

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Eman Y. Z. Frag ◽  
Gehad G. Mohamed ◽  
Mohamed M. Khalil ◽  
Mohammad M. A. Hwehy
Keyword(s):  
Biological Fluid ◽  
Pharmaceutical Preparations ◽  
Standard Addition ◽  
Selectivity Coefficient ◽  
Potentiometric Determination ◽  
Pvc Membrane ◽  
Membrane Electrodes ◽  
Carbon Paste ◽  
Ketotifen Fumarate

This study compares between unmodified carbon paste (CPE; the paste has no ion pair) and polyvinyl chloride (PVC) membrane selective electrodes that were used in potentiometric determination of ketotifen fumarate (KTF), where sodium tetraphenylborate (NaTPB) was used as titrant. The performance characteristics of these sensors were evaluated according to IUPAC recommendations which reveal a fast, stable, and linear response for KTF over the concentration range of 10−7to 10−2 mol L−1. The electrodes show Nernstian slope value of and  mV decade−1for CPE and PVC membrane electrodes at 30∘C, respectively. The potential is nearly stable over the pH range 3.0–6.0 and 2.0–7.0 for CPE and PVC membrane electrodes, respectively. Selectivity coefficient values towards different inorganic cations, sugars, and amino acids reflect high selectivity of the prepared electrodes. The electrodes responses at different temperatures were also studied, and long operational lifetime of 12 and 5 weeks for CPE and PVC membrane electrodes, respectively, were found. These are used for determination of ketotifen fumarate using potentiometric titration, calibration, and standard addition methods in pure samples, its pharmaceutical preparations (Zaditen tablets), and biological fluid (urine). The direct potentiometric determination of KTF using the proposed sensors gave recoveries % of and with RSD 1.42 and 0.63% for CPE and PVC membrane selective electrodes, respectively. Validation of the method shows suitability of the proposed sensors for use in quality control assessment of KTF. The obtained results were in a good agreement with those obtained using the reported spectrophotometric method.

Modified Screen-Printed Ion Selective Electrodes for Potentiometric Determination of Sodium Dodecylsulfate in Different Samples

2015 ◽  
Vol 98 (1) ◽  
pp. 116-123 ◽  
Author(s):  
Tamer Awad Ali ◽  
Gehad G Mohamed
Keyword(s):  
Response Times ◽  
Inorganic Compounds ◽  
Cetylpyridinium Chloride ◽  
Sodium Dodecylsulfate ◽  
Direct Determination ◽  
Pharmaceutical Preparations ◽  
Ion Association ◽  
Potentiometric Determination ◽  
Screen Printed

Abstract Fabrication and general performance characteristics of novel screen-printed sensors for potentiometric determination of sodium dodecylsulfate (SDS) are described. The sensors are based on the use of ion-association complexes of SDS with cetylpyridinium chloride (electrode I) and cetyltrimethylammonium bromide (electrode II) as exchange sites in a screen-printed electrode matrix. Electrodes (I) and (II) show fast, stable, and near-Nernstian response for the mono-charge anion of SDS over the concentration range of1 × 10–2 – 5.8 × 10–7 and 1 × 10–2 – 6.3 × 10–7 mol/L at 25°C and the pH range of 2.0–9.0 and 2.0–8.0 with anionic slope of 57.32 ± 0.81 and 56.58 ± 0.65 mV/decade, respectively. Electrodes (I) and (II) have lower LODs of 5.8 × 10–7 and 6.3 × 10–7 mol/L and response times of about 8 and 13 s, respectively. Shelf life of5 months for both electrodes is adequate. Selectivity coefficients of SDS related to a number of interfering cations, and some inorganic compounds were investigated. There were negligible interferences causedby most of the investigated species. The direct determination of 0.10–13.50 mg of SDS by electrodes (I) and (II) shows average recoveries of 99.96 and 99.85%, and mean RSDs of 0.83 and 1.04%, respectively. In the present investigation, both electrodes were used successfully as end point indicators for determination of SDS in pure pharmaceutical preparations and real spiked water samples. The results obtained using the proposed sensors to determine SDS in solution compared favorably with those obtained by thestandard addition method.

scholarly journals Disposable gold nanoparticle functionalized and bare screen-printed electrodes for potentiometric determination of trazodone hydrochloride in pure form and pharmaceutical preparations

RSC Advances ◽  
2018 ◽  
Vol 8 (21) ◽  
pp. 11517-11527 ◽  
Author(s):  
Fathy M. Salama ◽  
Khalid A. Attia ◽  
Ragab A. Said ◽  
Ahmed El-Olemy ◽  
Ahmed M. Abdel-raoof
Keyword(s):  
Gold Nanoparticles ◽  
Gold Nanoparticle ◽  
Electrochemical Sensors ◽  
Pharmaceutical Preparations ◽  
Potentiometric Determination ◽  
Chemically Modified ◽  
Screen Printed Electrodes ◽  
Trazodone Hydrochloride ◽  
Screen Printed

In the present study, screen-printed electrodes unmodified and chemically modified with gold nanoparticles were used as sensitive electrochemical sensors for the determination of trazodone hydrochloride.

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