Age-Related Bone Mineral Density, Accumulated Bone Loss Rate and Prevalence of Osteoporosis at Multiple Skeletal Sites in Chinese Women

2002 ◽  
Vol 13 (8) ◽  
pp. 669-676 ◽  
Author(s):  
Er-Yuan Liao ◽  
Xian-Ping Wu ◽  
Xiao-Ge Deng ◽  
Gan Huang ◽  
Xu-Ping Zhu ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Loss ◽  
Bone Mineral ◽  
Loss Rate ◽  
Chinese Women ◽  
Mineral Density ◽  
Age Related ◽  
Bone Loss Rate ◽  
Prevalence Of Osteoporosis

scholarly journals Artificial neural networks to predict future bone mineral density and bone loss rate in Japanese postmenopausal women

2017 ◽  
Vol 10 (1) ◽  
Author(s):  
Mitsunori Shioji ◽  
Takehisa Yamamoto ◽  
Takeshi Ibata ◽  
Takayuki Tsuda ◽  
Kazushige Adachi ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Neural Networks ◽  
Artificial Neural Networks ◽  
Bone Loss ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Loss Rate ◽  
Mineral Density ◽  
Artificial Neural ◽  
Bone Loss Rate

Relationship of age-related concentrations of serum FSH and LH with bone mineral density, prevalence of osteoporosis in native Chinese women

2009 ◽  
Vol 400 (1-2) ◽  
pp. 8-13 ◽  
Author(s):  
Zhang-Rong Xu ◽  
Ai-Hong Wang ◽  
Xian-Ping Wu ◽  
Hong Zhang ◽  
Zhi-Feng Sheng ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Chinese Women ◽  
Mineral Density ◽  
Age Related ◽  
Relationship Of ◽  
Prevalence Of Osteoporosis

scholarly journals Profiles of Endogenous Circulating Cortisol and Bone Mineral Density in Healthy Elderly Men1

1999 ◽  
Vol 84 (9) ◽  
pp. 3058-3063 ◽  
Author(s):  
E. Dennison ◽  
P. Hindmarsh ◽  
C. Fall ◽  
S. Kellingray ◽  
D. Barker ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Bone Density ◽  
Bone Loss ◽  
Bone Mineral ◽  
Loss Rate ◽  
Cortisol Concentration ◽  
Mineral Density ◽  
Healthy Elderly ◽  
Bone Loss Rate

Exogenous glucocorticoids are known to increase the risk of osteoporosis. However, the contribution made by endogenous circulating cortisol concentrations to adult skeletal status remains unknown. We examined this issue in a sample of 34 healthy men, aged 61–72 yr. Venous blood samples were obtained under standard conditions every 20 min over a 24-h period. Measurements were made of serum cortisol and cortisol-binding globulin. Bone mineral density was measured at the lumbar spine and proximal femur using dual energy x-ray absorptiometry. Measurements were made at baseline and 4 yr later. There was a weak negative association between integrated cortisol concentration and lumbar spine bone density (r = −0.37; P < 0.05); similar relationships (P < 0.05) existed at three of five proximal femoral sites. There were also statistically significant positive associations between the trough cortisol concentration and bone loss rate at the lumbar spine (r = 0.38; P < 0.05), femoral neck (r = 0.47; P < 0.001), and the trochanteric region (r = 0.41; P = 0.02) over the 4-yr follow-up period. The cross-sectional relationships between cortisol concentration and bone density were removed by adjustment for body mass index, but the influence on bone loss rate remained significant after adjusting for adiposity, cigarette smoking, alcohol consumption, dietary calcium intake, physical activity, and serum testosterone and estradiol levels. These observations suggest that the endogenous cortisol profile of healthy elderly men is a determinant of their bone mineral density and their rate of involutional bone loss.

scholarly journals Cardiovascular disease is a risk factor for osteoporosis: a case-control study in Chinese women

2020 ◽  
Author(s):  
Hao Chai ◽  
Jirong Ge ◽  
Li Li ◽  
Jianyang Li ◽  
Yunjin Ye
Keyword(s):  
Bone Mineral Density ◽  
Cardiovascular Disease ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Retrospective Study ◽  
Bone Mineral ◽  
Chinese Women ◽  
Baseline Survey ◽  
Mineral Density ◽  
Age Related

Abstract Background: Osteoporosis and cardiovascular disease (CVD) are age-related diseases. According to some studies, patients with CVD have a higher risk of bone loss. This retrospective study intended to reveal the correlation between osteoporosis and CVD in Chinese women. Although epidemiological evidence has provided evidence of the relationship between the two, it lacks clinical data in southeast China.Methods: The 2873 participants completed the baseline survey from January 2007 to October 2019, and 2496 were included in this retrospective study. We divided all subjects into the osteoporosis group and the non-osteoporosis group based on their bone mineral density. Dual-energy x-ray absorptiometry (DXA) was used to examine bone mineral density. The general information came from the questionnaire survey and medical records. Results: According to the criterion, the osteoporosis group had 799 subjects, with a mean age of 64.19 years. The non-osteoporosis group had 1697 subjects, with a mean age of 61.03 years. Subjects in the osteoporosis group had a significantly higher prevalence of hypertension and coronary heart disease. Besides, there was a higher probability of drinking tea and drinking milk in the osteoporosis group. In correlation analysis, the occurrence of osteoporosis correlated positively with hypertension and coronary heart disease. Logistic regression analysis showed that the odds of osteoporosis was high if participants had hypertension, coronary heart disease, or drank tea and drank milk. Conclusions: This study indicated that patients with osteoporosis had a higher prevalence of CVD in Chinese women, and CVD is one of the hazard factors for osteoporosis.

scholarly journals 3-Hydroxyanthranilic acid Administration Did Not Prevent Age Related Bone Loss

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 680-681
Author(s):  
Carlos Isales ◽  
Ke-Hong Ding ◽  
Wendy Bollag ◽  
Meghan McGee-Lawrence ◽  
William Hill ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Body Composition ◽  
Bone Loss ◽  
Bone Mineral ◽  
Degradation Products ◽  
High Dose ◽  
Mineral Density ◽  
Tryptophan Degradation ◽  
Age Related ◽  
Hydroxyanthranilic Acid

Abstract Aging is associated with accumulation of various tryptophan degradation products that may having either bone anabolic or catabolic effects. In epidemiologic studies, elevated levels of 3-hydroxyanthranilic acid (3-HAA) are associated with a higher bone mineral density (BMD). We have previously shown that the C57BL/6 mouse loses bone mass with age. Thus, we hypothesized that administering 3-HAA via a daily intraperitoneal (IP) injection would result in preserved or increased BMD. In an IACUC-approved protocol, we injected 26-month-old C57BL/6 mice with either a low dose (0.5 mg) or high dose (5 mg) of 3-HAA IP five days a week for eight weeks. At the end of this time mice were sacrificed and body composition and bone mineral density measured by DigiMus. BMD was significantly lower in the high dose 3-HAA group: 0.0570 + 0.004 vs 0.0473 + 0.006 vs 0.0432 + 0.0075 gm/cm2, (means+SD, Control vs 0.5 mg 3HAA vs 5 mg 3HAA, p=0.004, 0 vs 5.0 mg, n=6-9/group). 3-HAA had no significant impact on body composition (lean body mass: 86.7 + 1.7% vs 86.2 + 2.7% vs 86.1 + 2.0%, Control vs 0.5 mg vs 5.0 mg 3-HAA, p=ns; and fat mass 12.6 + 2.0% vs 13.8 + 2.7% vs 13.9 + 2.0% vs 0.2%, Control vs 0.5 vs 5 mg 3-HAA, p=ns). Thus, 3-HAA did not prevent bone loss in older mice but instead significantly worsened bone loss. 3-HAA is known to have both pro- and anti- oxidant effects depending on the environment. These data would suggest that at the higher concentrations 3-HAA is acting predominantly as a pro-oxidant molecule accelerating age-related bone loss.

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