scholarly journals Comments to: Velho G, Hattersley AT, Froguel P (2000) Maternal diabetes alters birth weight in glucokinase-deficient (MODY2) kindred but has no influence on adult weight, height, insulin secretion or insulin sensivity. Diabetologia 43: 1060-1063

Diabetologia ◽  
2001 ◽  
Vol 44 (4) ◽  
pp. 516-517
Author(s):  
Not Available Not Available
2002 ◽  
Vol 187 (4) ◽  
pp. 922-926 ◽  
Author(s):  
Myriam A.J. Mondestin ◽  
Cande V. Ananth ◽  
John C. Smulian ◽  
Anthony M. Vintzileos

1987 ◽  
Vol 109 (3) ◽  
pp. 445-452 ◽  
Author(s):  
M. J. Nicholson

SummaryThe effects of night enclosure and walking 3000 km on growing and breeding cattle were examined over an 8-month period. Walking consisted of an 8 h walk of 40 km every 3rd day and experimental cattle were enclosed each night for 11 h. In addition, all cattle were allowed water once every 3 days. In cattle which both walked and were enclosed, a reduction of nearly 40% in grazing time was recorded. This was associated with a depression of dry-matter intake of only 12%, suggesting an intensification of eating in response to a restriction of grazing time. The overall effects of walking and enclosing on productivity, as determined by adult weight loss, calf and weaner growth, calving percentage and birth weight, were negligible and masked by the greater effects of poor nutrition during the dry season which affected all the animals. It is concluded that the additional energetic requirements for walking are small and this is attributed to adaptation, fitness and a possible depression of metabolic rate. These factors may explain why the observed costs of walking were lower than those reported in the literature.


Author(s):  
Munera Awad Radwan ◽  
Najia Abdelati El Mansori ◽  
Mufeda Ali Elfergani ◽  
Faiaz Ragab Halies ◽  
Mohanad Abdulhadi Lawgali

Introduction: Diabetes has long been associated with maternal and perinatal morbidity and mortality. The infant of a diabetic mother have higher risks for serious problems during pregnancy and at birth. Problems during pregnancy may include increased risks of abortions and stillbirths. Abnormal fetal metabolism during pregnancy complicated by maternal diabetes mellitus results in multiple neonatal sequallae, including abnormalities of growth, glucose and calcium metabolism, hematologic status, cardio- respiratory function, bilirubin metabolism, and congenital anomalies. The causes of the fetal and neonatal sequallae of maternal diabetes are Multifactorial. However, many of the perinatal complications can be traced to the effect of maternal glycemic control on the fetus & can be prevented by appropriate periconceptional & prenatal care. Objective:  to describe the morbidity pattern among infants of diabetic mothers (IDMs) either gestational or preconception diabetes mellitus. Methods:  A cross sectional study was conducted in Jamhouria hospital/ neonatal ward & enrolled 120 consecutive infants born to diabetics mother either gestational or preconception diabetes mellitus over one year period. Results: 120 babies were diagnosed as IDMs and were admitted to Neonatal intensive care unit, male, female, 74(60.8%) were gestational diabetes, and 46 (38.3%) with preconception diabetes, full term comprise 98 cases (81.6%) while premature were 22 cases (18.3%). For birth weight 20 case [16.7%} were low birth weight, macrosomia represent 16 case (13.3%). Most common congenital anomalies was cardiac lesion 36 cases, for GDM 18 case =24.3% were PCDM 18 case around 40.0%. Central nervous system 11 case (9.1%) all of them dilated ventricular system& only 2 of them need surgical intervention with shunt. Gastrointestinal anomalies 4 cases {3.4%} 2 of them ectopic anus & 2 short bowel syndrome. Most common metabolic disturbance was Hypocalcemia 17 case (14.1%), followed by hypoglycemia 11 case (9.1%), followed with hyper bilirubinemia 3 cases (2.5%) Followed by Respiratory distress syndrome 26 case (21.6%), 17 case hyaline membrane disease (14.1%) ,transient tachypnea of neo born 9 cases (7.5%) , Birth trauma  3 cases Erb,s palsy one of them  birth asphyxia. Conclusion: Most common type of diabetes in pregnancy is gestational diabetes, and most common congenital anomalies is the cardiac lesion & the most common metabolic disturbance is the hypocalcemia. Macrosomia associated with large birth weight as well as birth trauma. Large for gestational age and hypoglycemia associated mainly with poor maternal glycemic control.


Metabolites ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 387
Author(s):  
Valeria Calcaterra ◽  
Angela Zanfardino ◽  
Gian Vincenzo Zuccotti ◽  
Dario Iafusco

Maturity-onset diabetes of the young (MODY) represents a heterogenous group of monogenic autosomal dominant diseases, which accounts for 1–2% of all diabetes cases. Pregnancy represents a crucial time to diagnose MODY forms due to the 50% risk of inheritance in offspring of affected subjects and the potential implications on adequate fetal weight. Not only a history of maternal diabetes may affect the birth weight of offspring, paternal diabetes should also be taken into consideration for a correct pathogenetic diagnosis. The crucial role of maternal and paternal diabetes inheritance patterns and the impact of this inherited mutation on birthweight and the MODY diagnosis was discussed.


2014 ◽  
Vol 6 (1) ◽  
pp. 27-37 ◽  
Author(s):  
C. Madsen ◽  
P. Mogensen ◽  
N. Thomas ◽  
D. L. Christensen ◽  
I. C. Bygbjerg ◽  
...  

Physical inactivity and low birth weight (LBW) may lead to an increased risk for developing type 2 diabetes. The extent to which LBW individuals may benefit from physical exercise training when compared with those with normal birth weight (NBW) controls is uncertain. We assessed the impact of an outdoor exercise intervention on body composition, insulin secretion and action in young men born with LBW and NBW in rural India. A total of 61 LBW and 56 NBW healthy young men were recruited into the study. The individuals were instructed to perform outdoor bicycle exercise training for 45 min every day. Fasting blood samples, intravenous glucose tolerance tests and bioimpedance body composition assessment were carried out. Physical activity was measured using combined accelerometry and heart rate monitoring during the first and the last week of the intervention. Following the exercise intervention, the LBW group displayed an increase in physical fitness [55.0 ml (O2)/kg min (52.0−58.0)−57.5 ml (O2)/kg min (54.4−60.5)] level and total fat-free mass [10.9% (8.0−13.4)−11.4% (8.0−14.6)], as well as a corresponding decline in the ratio of total fat mass/fat-free mass. In contrast, an increase in total fat percentage as well as total fat mass was observed in the NBW group. After intervention, fasting plasma insulin levels, homoeostasis model assessments (HOMA) of insulin resistance (HOMA-IR) and insulin secretion (HOMA-IS), improved to the same extent in both the groups. In summary, young men born with LBW in rural India benefit metabolically from exercise training to an extent comparable with NBW controls.


2018 ◽  
Vol 172 (9) ◽  
pp. 867 ◽  
Author(s):  
Martina Persson ◽  
Prakesh S. Shah ◽  
Franca Rusconi ◽  
Brian Reichman ◽  
Neena Modi ◽  
...  

Diabetes Care ◽  
1998 ◽  
Vol 21 (10) ◽  
pp. 1652-1658 ◽  
Author(s):  
D. E. Yarbrough ◽  
E. Barrett-Connor ◽  
D. Kritz-Silverstein ◽  
D. L. Wingard

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