Aryl hydrocarbon or dioxin receptor: Biologic and toxic responses

1993 ◽  
pp. 1-42 ◽  
Author(s):  
K. W. Bock
Keyword(s):  
Aryl Hydrocarbon ◽  
Toxic Responses ◽  
Dioxin Receptor

scholarly journals Aryl Hydrocarbon Receptor Nuclear Translocator in Hepatocytes Is Required for Aryl Hydrocarbon Receptor–Mediated Adaptive and Toxic Responses in Liver

2010 ◽  
Vol 118 (2) ◽  
pp. 554-563 ◽  
Author(s):  
Manabu Nukaya ◽  
Jacqueline A. Walisser ◽  
Susan M. Moran ◽  
Gregory D. Kennedy ◽  
Christopher A. Bradfield
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Aryl Hydrocarbon ◽  
Toxic Responses

scholarly journals Recruitment of Dioxin Receptor to Active Transcription Sites

2002 ◽  
Vol 13 (6) ◽  
pp. 2001-2015 ◽  
Author(s):  
Cem Elbi ◽  
Tom Misteli ◽  
Gordon L. Hager
Keyword(s):  
Transcription Factor ◽  
Target Genes ◽  
Biological Effects ◽  
Dependent Manner ◽  
Regulatory Domains ◽  
Aryl Hydrocarbon ◽  
Transcription Sites ◽  
Active Transcription ◽  
Ligand Stimulation ◽  
Dioxin Receptor

The aryl hydrocarbon receptor (AhR or dioxin receptor) is a ligand-activated transcription factor that heterodimerizes with the AhR nuclear translocator (ARNT/HIF-1β) to form an AhR/ARNT transcription factor complex. This complex binds to specific DNA sites in the regulatory domains of numerous target genes and mediates the biological effects of exogenous ligands. Herein, we have investigated the subcellular distribution of the AhR/ARNT complex in response to ligand stimulation, by using live-cell confocal and high-resolution deconvolution microscopy. We found that unliganded AhR shows a predominantly cytoplasmic diffuse distribution in mouse hepatoma cells. On addition of ligand, AhR rapidly translocates to the nucleus and accumulates in multiple bright foci. Inhibition of transcription prevented the formation of AhR foci. Dual- and triple-immunolabeling experiments, combined with labeling of nascent RNA, showed that the foci are transcription sites, indicating that upon ligand stimulation, AhR is recruited to active transcription sites. The interaction of AhR with ARNT was both necessary and sufficient for the recruitment of AhR to transcription sites. These results indicate that AhR/ARNT complexes are recruited to specific subnuclear compartments in a ligand-dependent manner and that these foci represent the sites of AhR target genes.

scholarly journals Dioxin-like Activity in Pregnant Women and Indices of Fetal Growth: The ACCEPT Birth Cohort

Toxics ◽  
2022 ◽  
Vol 10 (1) ◽  
pp. 26
Author(s):  
Manhai Long ◽  
Maria Wielsøe ◽  
Eva Cecilie Bonefeld-Jørgensen
Keyword(s):  
Pregnant Women ◽  
Fetal Growth ◽  
Serum Lipid ◽  
Normal Weight ◽  
Growth Indices ◽  
Serum Samples ◽  
Aryl Hydrocarbon ◽  
Median Level ◽  
Marine Food ◽  
Toxic Responses

Exposure to lipophilic persistent organic pollutants (lipPOPs) elicits a number of species- and tissue-specific toxic responses, many of which involve the aryl hydrocarbon receptor (AhR). This study aims to measure the combined serum dioxin-like activity of lipPOPs in Greenlandic Inuit pregnant women and the associations with fetal growth indices. The combined dioxin-like activity of serum lipPOPs extracts was determined using the AhR reporter gene bioassay and expressed as pico-gram (pg) TCDD equivalent (TEQ) per gram serum lipid [AhR-TEQ (pg/g lipid)]. Significant AhR-TEQ was found in > 87% of serum samples with the median level of 86.2 pg TEQ/g lipid. The AhR-TEQ level positively correlated with the marine food intake biomarker n-3/n-6 polyunsaturated fatty acids ratio, while negatively correlated with body mass index and parity. Women giving birth to infants with low birth weight (<2500 g) and length (<50 cm) had higher AhR-TEQ level compared to those with normal weight and length infants. For previous smokers, we found significant inverse associations between maternal AhR-TEQ level and fetal growth indices. In conclusion, exposure of Greenlandic Inuit pregnant women to dioxin-like compounds through traditional marine food can adversely influence the fetal growth via induced AhR activity. Smoking might have modifying effects.

scholarly journals Exactly the Same but Different: Promiscuity and Diversity in the Molecular Mechanisms of Action of the Aryl Hydrocarbon (Dioxin) Receptor

2011 ◽  
Vol 124 (1) ◽  
pp. 1-22 ◽  
Author(s):  
Michael S. Denison ◽  
Anatoly A. Soshilov ◽  
Guochun He ◽  
Danica E. DeGroot ◽  
Bin Zhao
Keyword(s):  
Molecular Mechanisms ◽  
Mechanisms Of Action ◽  
Aryl Hydrocarbon ◽  
Dioxin Receptor

Aryl Hydrocarbon Receptor Activation Produces Heart-Specific Transcriptional and Toxic Responses in Developing Zebrafish

2006 ◽  
Vol 70 (2) ◽  
pp. 549-561 ◽  
Author(s):  
Sara A. Carney ◽  
Jing Chen ◽  
C. Geoffrey Burns ◽  
Kong M. Xiong ◽  
Richard E. Peterson ◽  
...  
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Receptor Activation ◽  
Aryl Hydrocarbon ◽  
Toxic Responses

scholarly journals Common Commercial and Consumer Products Contain Activators of the Aryl Hydrocarbon (Dioxin) Receptor

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e56860 ◽  
Author(s):  
Bin Zhao ◽  
Jessica E. S. Bohonowych ◽  
Alicia Timme-Laragy ◽  
Dawoon Jung ◽  
Alessandra A. Affatato ◽  
...  
Keyword(s):  
Consumer Products ◽  
Aryl Hydrocarbon ◽  
Dioxin Receptor
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