scholarly journals Exactly the Same but Different: Promiscuity and Diversity in the Molecular Mechanisms of Action of the Aryl Hydrocarbon (Dioxin) Receptor

2011 ◽  
Vol 124 (1) ◽  
pp. 1-22 ◽  
Author(s):  
Michael S. Denison ◽  
Anatoly A. Soshilov ◽  
Guochun He ◽  
Danica E. DeGroot ◽  
Bin Zhao
Keyword(s):  
Molecular Mechanisms ◽  
Mechanisms Of Action ◽  
Aryl Hydrocarbon ◽  
Dioxin Receptor

scholarly journals Endocrine disruptive chemicals: mechanisms of action and involvement in metabolic disorders

2009 ◽  
Vol 43 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Elin Swedenborg ◽  
Joëlle Rüegg ◽  
Sari Mäkelä ◽  
Ingemar Pongratz
Keyword(s):  
Endocrine Disruption ◽  
Metabolic Disorders ◽  
Molecular Mechanisms ◽  
Fat Metabolism ◽  
Mechanisms Of Action ◽  
Mediating Effects ◽  
Aryl Hydrocarbon ◽  
Metabolic Functions ◽  
Considerable Concern

Endocrine disruption refers to the ability of chemicals to interfere with hormonal systems, and has raised considerable concern in recent years. Endocrine disruptive chemicals (EDCs) pose a documented risk to wildlife and have the potential to negatively influence human health. This review focuses on the molecular mechanisms of endocrine disruption and the possible involvement of EDCs in metabolic disorders. The first part describes the role of aryl hydrocarbon receptor (AhR) and nuclear receptors (NRs) in mediating effects of EDCs, in particular, how cross-talk between AhR and NR pathways can lead to endocrine disruption. The second part deals with how these receptors are involved in metabolic functions and how their targeting by EDCs can lead to disturbances in glucose and fat metabolism. The article illustrates that, although there is accumulating data on molecular mechanisms of EDC action as well as on EDC involvement in metabolic disorders, there is still a great demand for data that can unite the mechanistic and the toxicological/epidemiological observations.

scholarly journals The correlation between lncRNAs and Helicobacter pylori in gastric cancer

2019 ◽  
Vol 77 (9) ◽  
Author(s):  
Narges Dastmalchi ◽  
Seyed Mahdi Banan Khojasteh ◽  
Mirsaed Miri Nargesi ◽  
Reza Safaralizadeh
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Molecular Mechanisms ◽  
Gastrointestinal Diseases ◽  
Mechanisms Of Action ◽  
Molecular Pathways ◽  
Gastric Diseases ◽  
Non Coding Rnas ◽  
H Pylori ◽  
The Relationship

ABSTRACT Helicobacter pylori infection performs a key role in gastric tumorigenesis. Long non-coding RNAs (lncRNAs) have demonstrated a great potential to be regarded as effective malignancy biomarkers for various gastrointestinal diseases including gastric cancer (GC). The present review highlights the relationship between lncRNAs and H. pylori in GC. Several studies have examined not only the involvement of lncRNAs in H. pylori-associated GC progression but also their molecular mechanisms of action. Among the pertinent studies, some have addressed the effects of H. pylori infection on modulatory networks of lncRNAs, while others have evaluated the effects of changes in the expression level of lncRNAs in H. pylori-associated gastric diseases, especially GC. The relationship between lncRNAs and H. pylori was found to be modulated by various molecular pathways.

scholarly journals Gene Transcription as a Therapeutic Target in Leukemia

2021 ◽  
Vol 22 (14) ◽  
pp. 7340
Author(s):  
Alvina I. Khamidullina ◽  
Ekaterina A. Varlamova ◽  
Nour Alhuda Hammoud ◽  
Margarita A. Yastrebova ◽  
Alexandra V. Bruter
Keyword(s):  
Gene Transcription ◽  
Molecular Mechanisms ◽  
Hematological Malignancies ◽  
Mechanisms Of Action ◽  
Special Program ◽  
Cell Plasticity ◽  
Hematopoietic Stem ◽  
Promising Strategy ◽  
Tumor Cell Plasticity ◽  
Transcriptional Landscape

Blood malignancies often arise from undifferentiated hematopoietic stem cells or partially differentiated stem-like cells. A tight balance of multipotency and differentiation, cell division, and quiescence underlying normal hematopoiesis requires a special program governed by the transcriptional machinery. Acquisition of drug resistance by tumor cells also involves reprogramming of their transcriptional landscape. Limiting tumor cell plasticity by disabling reprogramming of the gene transcription is a promising strategy for improvement of treatment outcomes. Herein, we review the molecular mechanisms of action of transcription-targeted drugs in hematological malignancies (largely in leukemia) with particular respect to the results of clinical trials.

FK778: New Cellular and Molecular Mechanisms of Action

2006 ◽  
Vol 38 (3) ◽  
pp. 757-761 ◽  
Author(s):  
S. Schrepfer ◽  
T. Deuse ◽  
F. Koch-Nolte ◽  
C. Detter ◽  
H. Reichenspurner
Keyword(s):  
Molecular Mechanisms ◽  
Mechanisms Of Action

Molecular Mechanisms of Action of Bacterial Exotoxins

1996 ◽  
Vol 284 (2-3) ◽  
pp. 170-206 ◽  
Author(s):  
Joachim Balfanz ◽  
Peter Rautenberg ◽  
Uwe Ullmann
Keyword(s):  
Molecular Mechanisms ◽  
Mechanisms Of Action
Sign in / Sign up

Export Citation Format

Share Document