The gonadotroph origin of null cell adenomas

HORMONES ◽  
2016 ◽  
Vol 15 (2) ◽  
pp. 243-247 ◽  
Author(s):  
George Kontogeorgos ◽  
Eleni Thodou
Keyword(s):  
Null Cell ◽  
Null Cell Adenomas

Immunonegative "Null Cell" Adenomas and Gonadotropin (Gn) Subunit (SUs) Immunopositive Adenomas Share Frequent Expression of Multiple Transcription Factors

2006 ◽  
Vol 17 (1) ◽  
pp. 35-44 ◽  
Author(s):  
Yudo Ishii ◽  
Masanori Suzuki ◽  
Susumu Takekoshi ◽  
Noboru Egashira ◽  
Michio Yamazaki ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Null Cell ◽  
Null Cell Adenomas

Null cell adenomas, oncocytomas, and gonadotroph adenomas of the human pituitary: An immunocytochemical and ultrastructural anafysis of 300 cases

1993 ◽  
Vol 4 (1) ◽  
pp. 20-27 ◽  
Author(s):  
George Kontogeorgos ◽  
Kalman Kovacs ◽  
Eva Horvath ◽  
Bernd W. Scheithauer
Keyword(s):  
Null Cell ◽  
Human Pituitary ◽  
Null Cell Adenomas

The immunohistochemical and radiological features of nonfunctioning pituitary adenomas

2015 ◽  
Vol 61 (6) ◽  
pp. 4-9 ◽  
Author(s):  
Anna Konstantinovna Lipatenkova ◽  
Larisa Konstantinovna Dzeranova ◽  
Ekaterina Aleksandrovna Pigarova ◽  
Nadezhda Sergeevna Dalantaeva ◽  
Ljudmila Igorevna Astaf'eva ◽  
...  
Keyword(s):  
Pituitary Adenomas ◽  
Area Under The Curve ◽  
Pituitary Hormones ◽  
Serum Markers ◽  
Invasive Growth ◽  
Null Cell ◽  
Ki 67 ◽  
Nonfunctioning Pituitary Adenomas ◽  
Radiological Features ◽  
Null Cell Adenomas

Pituitary adenomas without clinically active hypersecretion are summarized under the term nonfunctioning pituitary adenomas (NFPAs). Since there are no specific serum markers, the differential diagnosis and treatment imply special difficulties.Aim.To investigate the immunohistochemical and radiological features of NFPAs and assess the granins — chromogranin A (CgA), secretogranin II (SgII), secretoneurin (Sn) as immunohistochemical markers of NFPAs.Matherial and methods.50 pituitary adenomas excised surgically were immunostained to reveal pituitary hormones, ki-67, CgА. SgII, Sn. All patients underwent MRI, invasive growth was estimated due to J.Hardy classification (1973).Results.24 (51,1%) were gonadotropic tumors, 12 (25,5%) — null cell adenomas. Immunopositivity for ACTH was determined in 6 cases (12,7%), for GH in 5 (10,6%) cases, for PRL in 4 (8,5%). The median level of ki-67 was 2% (min. — 0.5%, max. — 7%). The CgA, SgII, Sn immunopositivity was found in 83, 93,6, 85,1% respectively, being more expressed in gonadotropinomas and null cell adenomas. Invasive growth was detected in 28 (44%) cases, among the invasive adenomas 22 tumors were giant. CgA expression is adverse prognostic factor, area under the curve (AUC) with 0,705. We did not find any correlation between ACTH-, STH-, CgII- and Sn- immunopositivity, ki-67 and invasive growth.Conclusions.Our work shows that a majority of NFPAs are truly secreting adenomas with significant numbers comprising potentially hazardous cortico- and somatotropinomas. CgA, SgII and Sn have a high expression in most of the NFPAs.

Clinical, pathologic, and imaging characteristics of pituitary null cell adenomas as defined according to the 2017 World Health Organization criteria: a case series from two pituitary centers

Pituitary ◽  
2019 ◽  
Vol 22 (5) ◽  
pp. 514-519 ◽  
Author(s):  
Joao Paulo Almeida ◽  
Corbin C. Stephens ◽  
Jennifer M. Eschbacher ◽  
Michelle M. Felicella ◽  
Kevin C. J. Yuen ◽  
...  
Keyword(s):  
World Health Organization ◽  
Case Series ◽  
World Health ◽  
Null Cell ◽  
Imaging Characteristics ◽  
Health Organization ◽  
Null Cell Adenomas

Computer-assisted microscope analysis of feulgen-stained nuclei in gonadotroph adenomas and null-cell adenomas of the pituitary gland

1997 ◽  
Vol 8 (2) ◽  
pp. 109-120 ◽  
Author(s):  
M. Beatriz S. Lopes ◽  
Isabelle Salmon ◽  
Nathalie Nagy ◽  
Christine Decaestecker ◽  
Jean-Lambert Pasteels ◽  
...  
Keyword(s):  
Pituitary Gland ◽  
Computer Assisted ◽  
Null Cell ◽  
Microscope Analysis ◽  
Null Cell Adenomas

Gsα, protein kinase C, cathepsin D, growth factors, estrogen receptor-related protein, and p53 in prolactin cell adenomas and null cell adenomas of the pituitary

1998 ◽  
Vol 9 (2) ◽  
pp. 135-148
Author(s):  
Lars Wellhausen ◽  
Wolfgang Saeger ◽  
Wolf Müller ◽  
Michael Derwahl ◽  
Christiane Hamacher ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Protein Kinase C ◽  
Growth Factors ◽  
Protein Kinase ◽  
Cathepsin D ◽  
Related Protein ◽  
Null Cell ◽  
Prolactin Cell ◽  
Kinase C ◽  
Null Cell Adenomas

Inactivation of the p16 Gene in Human Pituitary Nonfunctioning Tumors by Hypermethylation Is More Common in Null Cell Adenomas

2001 ◽  
Vol 12 (3) ◽  
pp. 281-290 ◽  
Author(s):  
Katharina H Ruebel ◽  
Long Jin ◽  
Shuya Zhang ◽  
Bernd W Scheithauer ◽  
Ricardo V Lloyd
Keyword(s):  
Null Cell ◽  
Human Pituitary ◽  
P16 Gene ◽  
Null Cell Adenomas

Gonadotropin Secretion in Vitro by Human Pituitary Null Cell Adenomas and Oncocytomas**

1986 ◽  
Vol 62 (5) ◽  
pp. 1011-1019 ◽  
Author(s):  
SYLVIA L. ASA ◽  
BLAIR M. GERRIE ◽  
WILLIAM SINGER ◽  
EVA HORVATH ◽  
KALMAN KOVACS ◽  
...  
Keyword(s):  
Null Cell ◽  
Human Pituitary ◽  
Gonadotropin Secretion ◽  
Null Cell Adenomas
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