Decreased circulating 25-(OH) Vitamin D concentrations in obese female children and adolescents: Positive associations with Retinol Binding Protein-4 and Neutrophil Gelatinase-associated Lipocalin

HORMONES ◽  
2013 ◽  
Vol 12 (3) ◽  
pp. 397-404 ◽  
Author(s):  
Dimitra Metheniti ◽  
Sophia Sakka ◽  
Maria Dracopoulou ◽  
Alexandra Margeli ◽  
Ioannis Papassotiriou ◽  
...  
Keyword(s):  
Vitamin D ◽  
Children And Adolescents ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Retinol Binding Protein 4 ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Obese Female ◽  
Female Children ◽  
25 Oh Vitamin D ◽  
Neutrophil Gelatinase

scholarly journals Neutrophil Gelatinase-Associated Lipocalin and Retinol-Binding Protein-4 as Biomarkers for Diabetic Kidney Disease

2020 ◽  
Vol 45 (2) ◽  
pp. 222-232 ◽  
Author(s):  
Fatemeh Abbasi ◽  
Fatemeh Moosaie ◽  
Pegah Khaloo ◽  
Fatemeh Dehghani Firouzabadi ◽  
Seyede Marzie Fatemi Abhari ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Kidney Disease ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Control Group ◽  
Tubular Damage ◽  
Retinol Binding Protein 4 ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Neutrophil Gelatinase

Aims: This study was designed to evaluate the conflicting association between 2 tubular protein markers including neutrophil gelatinase-associated lipocalin (NGAL) and retinol-binding protein-4 (RBP-4) with albuminuria and glomerular filtration rate (GFR) and calculate the accuracy of the role of NGAL and RBP-4 in diagnosis of diabetic nephropathy (DN) in patients with type2 diabetes. Methods: This is a cross-sectional study that included 133 patients with type 2 diabetes. There were 3 diabetic study groups with normoalbuminuria, moderately increased albuminuria, severely increased albuminuria, and non-diabetic control group without any renal disease. We analyzed the difference of urinary NGAL (uNGAL) and RBP-4 between nondiabetics and diabetics, as well as within the diabetic group. We also assessed the association between albuminuria and NGAL and RBP-4. Results: The urinary levels of NGAL and RBP-4 were higher in patients with type 2 diabetes compared to nondiabetics as well as in albuminuric diabetics compared to nonalbuminuric patients with diabetes (p value <0.001). These 2 proteins were higher in patients with severely increased albuminuria compared to patients with moderately increased albuminuria, even after adjustment for other metabolic factors (all p < 0.01). Moreover, areas under the curve of NGAL and RBP-4 for the diagnosis of chronic kidney disease were 80.6 and 74.6%, respectively. Conclusion: uNGAL and RBP-4 are potential markers of tubular damage that may increase before the onset of glomerular markers such as albuminuria and GFR in patients with type 2 diabetes. Therefore, these markers can be used as complementary measurements to albuminuria and GFR in the earlier diagnosis of DN.

scholarly journals Assessment of Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Retinol-Binding Protein 4 (RBP4) in Type 2 Diabetic Patients with Nephropathy

2016 ◽  
Vol 11 ◽  
pp. BMI.S33191 ◽  
Author(s):  
Mohamed H. Mahfouz ◽  
Adel M. Assiri ◽  
Mohammed H. Mukhtar
Keyword(s):  
Early Detection ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Retinol Binding Protein 4 ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Neutrophil Gelatinase ◽  
Type 2 Diabetic

Diabetic nephropathy (DN) is one of the most serious microvascular complications of diabetes. The study aims to evaluate the diagnostic value of serum neutrophil gelatinase-associated lipocalin (NGAL) and retinol-binding protein 4 (RBP4) as biomarkers for early detection of nephropathy in type 2 diabetic patients. The current study was performed on 150 type 2 diabetic patients. These patients were classified into three equal groups according to their albumin/creatinine ratio (ACR), including patients with normoalbuminuria (ACR <30 mg/g creatinine), patients with microalbuminuria (ACR = 30–300 mg/g creatinine), and patients with macroalbuminuria (ACR >300 mg/g creatinine). Fifty apparently healthy subjects matching the same age and socioeconomic status with diabetic subjects were selected as a control group. The plasma glucose, insulin, glycosylated hemoglobin (HbA1c), homeostasis model assessment of insulin resistance (HOMA-IR), lipid profile, urea, creatinine, cystatin C, glomerular filtration rate (GFR), NGAL, and RBP4 were measured in the studied groups. Significantly elevated NGAL and RBP4 levels were observed in micro- and macroalbuminuric diabetic groups when compared to the control and normoalbuminuric diabetic groups. NGAL and RBP4 were found to correlate positively with duration of diabetes, systolic and diastolic blood pressure, glucose, HbA1c, HOMA-IR, triacylglycerol, and ACR, but correlate inversely with GFR in DN groups. Receiver operating characteristic curves revealed that for early detection of DN, the best cutoff values to discriminate DN and diabetic without nephropathy groups were 91.5 ng/mL for NGAL with 87% sensitivity, 74% specificity, and area under the curve (AUC) = 0.881; 24.5 ng/mL for RBP4 with 84% sensitivity, 90% specificity, and AUC = 0.912; and 37.5 mg/g creatinine for ACR with 89% sensitivity, 72% specificity, and AUC = 0.819. RBP4 is more specific (90% specificity) than NGAL (74% specificity) and ACR (72% specificity). Therefore, RBP4 marker may serve as a tool to follow-up clinical monitoring of the development and progression of DN.

Retinol-Binding Protein 4 Levels in Obese Children and Adolescents with Glucose Intolerance

2010 ◽  
Vol 73 (5) ◽  
pp. 335-340 ◽  
Author(s):  
D. Yeste ◽  
J. Vendrell ◽  
R. Tomasini ◽  
L.L. Gallart ◽  
M. Clemente ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Glucose Intolerance ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Obese Children ◽  
Retinol Binding Protein 4
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