scholarly journals Variability of serum concentrations of cystatin C and urinary retinol-binding protein, neutrophil gelatinase-associated lipocalin, immunoglobulin G, and C-reactive protein in dogs

2018 ◽  
Vol 32 (5) ◽  
pp. 1659-1664 ◽  
Author(s):  
D.J.X. Liu ◽  
E. Meyer ◽  
B.J.G. Broeckx ◽  
S. Daminet ◽  
J.R. Delanghe ◽  
...  
Keyword(s):  
Cystatin C ◽  
Immunoglobulin G ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Serum Concentrations ◽  
C Reactive Protein ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Reactive Protein ◽  
Neutrophil Gelatinase

scholarly journals Rapid diagnostic testing platform for iron and vitamin A deficiency

2017 ◽  
Vol 114 (51) ◽  
pp. 13513-13518 ◽  
Author(s):  
Zhengda Lu ◽  
Dakota O’Dell ◽  
Balaji Srinivasan ◽  
Elizabeth Rey ◽  
Ruisheng Wang ◽  
...  
Keyword(s):  
Vitamin A ◽  
Binding Protein ◽  
Vitamin A Deficiency ◽  
Work Capacity ◽  
Diagnostic Methods ◽  
Retinol Binding Protein ◽  
Micronutrient Deficiencies ◽  
C Reactive Protein ◽  
Laptop Computer ◽  
Reactive Protein

Micronutrient deficiencies such as those of vitamin A and iron affect a third of the world’s population with consequences such as night blindness, higher child mortality, anemia, poor pregnancy outcomes, and reduced work capacity. Many efforts to prevent or treat these deficiencies are hampered by the lack of adequate, accessible, and affordable diagnostic methods that can enable better targeting of interventions. In this work, we demonstrate a rapid diagnostic test and mobile enabled platform for simultaneously quantifying iron (ferritin), vitamin A (retinol-binding protein), and inflammation (C-reactive protein) status. Our approach, enabled by combining multiple florescent markers and immunoassay approaches on a single test, allows us to provide accurate quantification in 15 min even though the physiological range of the markers of interest varies over five orders of magnitude. We report sensitivities of 88%, 100%, and 80% and specificities of 97%, 100%, and 97% for iron deficiency (ferritin <15 ng/mL or 32 pmol/L), vitamin A deficiency (retinol-binding protein <14.7 μg/mL or 0.70 μmol/L) and inflammation status (C-reactive protein >3.0 μg/mL or 120 nmol/L), respectively. This technology is suitable for point-of-care use in both resource-rich and resource-limited settings and can be read either by a standard laptop computer or through our previously developed NutriPhone technology. If implemented as either a population-level screening or clinical diagnostic tool, we believe this platform can transform nutritional status assessment and monitoring globally.

scholarly journals Faktor-Faktor yang Memengaruhi Status Nutrisi Akut Pascabedah

Sari Pediatri ◽  
2016 ◽  
Vol 16 (3) ◽  
pp. 215
Author(s):  
Yusrina Istanti ◽  
Antonius Pudjiadi ◽  
Abdul Latief ◽  
Sri Martuti ◽  
Moh. Supriatna ◽  
...  
Keyword(s):  
Binding Protein ◽  
Retinol Binding Protein ◽  
C Reactive Protein ◽  
Reactive Protein

Latar belakang. Malnutrisi sering ditemukan pada pasien pascabedah dan berhubungan dengan penurunan fungsi otot, respirasi, imun serta penyembuhan luka yang terganggu. Tindakan pembedahan merupakan stresor yang memicu respons metabolik sehingga berpengaruh terhadap luaran, termasuk status nutrisi.Tujuan. Mengetahui faktor-faktor yang memengaruhi status nutrisi akut pascabedah.Metode. Penelitian observasional analitik dilakukan di ICU anak tiga rumah sakit, yaitu RS Cipto Mangunkusumo, RS Dr Kariadi, dan RSUD Dr Muwardi. Dilakukan pemeriksaan kadar retinol binding protein (RBP) hari ke-1 dan ke-5 pascabedah sebagai indikator status nutrisi, kortisol, dan C-reactive protein (CRP) sebagai marker respons inflamasi. Status nutrisi berdasarkan antropometri dinilai, jenis, dan lama pembedahan dicatat. Dilakukan uji korelasi untuk melihat hubungan antara kortisol, CRP, dan RBP dengan kadar RBP hari ke-5. Uji kai kuadrat untuk melihat hubungan status nutrisi, jenis dan lama pembedahan dengan kadar RBP hari ke-5.Hasil. Selama kurun waktu 6 bulan didapatkan 39 subjek yang memenuhi kriteria inklusi dan 4 subjek dieksklusi. Penurunan kadar RBP hari ke-5 dijumpai pada 12 (34,4%) subjek. Didapatkan hubungan antara kadar kortisol, CRP, dan RBP hari ke-1 dengan kadar RBP hari ke-5 [r=-0,35 (p=0,04); r=-0,53 (p=0,001); r=0,42 (p=0,01)]. Tidak terdapat hubungan antara status nutrisi berdasarkan antropometri serta jenis dan lama pembedahan dengan kadar RBP hari ke-5 (p>0,05).Kesimpulan. Terdapat hubungan antara kadar RBP hari ke-1 dan ke-5 sebagai parameter status nutrisi akut pascabedah. Kadar RBP hari ke-5 tidak dipengaruhi oleh status nutrisi prabedah serta jenis dan lama pembedahan, tetapi oleh kadar kortisol dan CRP sebagai marker respons stres.

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