Effect of different doses of naloxone on serum levels of prolactin and gonadotropins in young male volunteers

1985 ◽  
Vol 8 (1) ◽  
pp. 55-57 ◽  
Author(s):  
U. A. Knuth ◽  
E. Nieschlag
Keyword(s):  
Young Male ◽  
Serum Levels ◽  
Male Volunteers ◽  
Different Doses

Influence of oestradiol on alpha2-adrenoceptor binding sites on intact platelets of young male volunteers

1987 ◽  
Vol 33 (2) ◽  
pp. 147-150
Author(s):  
I. W. Reimann ◽  
C. Britzelmeier ◽  
P. Haber ◽  
H. Wollmann ◽  
K. H. Antonin ◽  
...  
Keyword(s):  
Binding Sites ◽  
Young Male ◽  
Male Volunteers ◽  
Alpha2 Adrenoceptor

scholarly journals Semen Quality, Hormonal Levels, and Androgen Receptor Gene Polymorphisms in a Population of Young Male Volunteers from Two Different Regions of Poland

2015 ◽  
Vol 21 ◽  
pp. 2494-2504
Author(s):  
Marzena Kamieniczna ◽  
Monika Fraczek ◽  
Agnieszka Malcher ◽  
Natalia Rozwadowska ◽  
Anna Czernikiewicz ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Gene Polymorphisms ◽  
Semen Quality ◽  
Receptor Gene ◽  
Young Male ◽  
Androgen Receptor Gene ◽  
Male Volunteers ◽  
Receptor Gene Polymorphisms ◽  
Hormonal Levels

Variability of pulsatile luteinizing hormone secretion in young male volunteers

1994 ◽  
Vol 131 (3) ◽  
pp. 263-272 ◽  
Author(s):  
Carl-Joachim Partsch ◽  
Sievert Abrahams ◽  
Niels Herholz ◽  
Michael Peter ◽  
Johannes D Veldhuis ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Half Life ◽  
Hormone Secretion ◽  
Young Male ◽  
Interpulse Interval ◽  
Luteinizing Hormone Secretion ◽  
Individual Subject ◽  
Deconvolution Analysis ◽  
Pulse Detection ◽  
Male Volunteers

Partsch C-J, Abrahams S, Herholz N, Peter M, Veldhuis JD, Sippell WG. Variability of pulsatile luteinizing hormone secretion in young male volunteers. Eur J Endocrinol 1994;131:263–72. ISSN 0804–4643 Characteristics of spontaneous pulsatile luteinizing hormone secretion were compared in ten young healthy men in three 24-h profiles obtained at intervals of 14 days and 3 months. The ages of the volunteers ranged from 19 to 25 years, and heights and weights were within normal limits. Blood samples were taken at 10-min intervals and plasma luteinizing hormone (LH) was determined in the same immunoradiometric assay using monoclonal antibodies. Conventional pulse detection was carried out with PULSAR and CLUSTER programs. In addition, a simultaneous multiple parameter DECONVOLUTION was applied. As a group, no significant differences between the three profile series were found for any of the calculated parameters of LH concentration or LH secretion. However, most parameters showed low correlation coefficients between the three study periods, suggesting that substantial individual variations might contribute to the more reliable group results. Median coefficients of variation (cv) for the individual subject ranged from 9.7% (interpulse interval and endogenous half-life) to 37.7% (mass per burst). However, the maximal individual cv observed was 78.4%. Intra-individual variability was lower than the variability between subjects for quantitative properties of LH concentration and secretion, although not significantly so for all parameters. In conventional pulse detection, the highest individual reliability was found for mean and integrated LH concentrations (median cv 10.2 and 13.7%, respectively), number of pulses per 24 h (CLUSTER, median cv 12.2%), mean pulse amplitude (PULSAR, median cv 10%) and interpulse interval (CLUSTER, median cv 9.7%). In DECONVOLUTION analysis, the endogenous LH half-life (median cv 9.7%), secretory burst amplitude (median cv 14.8%) and interburst interval (median cv 14.5%) revealed the lowest intra-individual variation. In contrast, the half-duration of a secretory episode and the mass of LH secreted per burst proved to be the least reliable measures (median cv 32.7% and 37.7%, respectively). Calculated endogenous LH production rates correlated highly (p < 0.01) across all three sessions. The relative frequencies of the LH peak amplitudes/heights and peak widths (durations) showed almost identical distribution curves for all three sampling periods. In conclusion, a high reproducibility of group results for both integrative parameters and pulse characteristics of LH concentrations and secretion were found in normal men. However, intra-individual reliability was variable and at times considerable, depending on the parameter chosen. These observations suggest caution in the interpretation of single LH profiles from individual subjects or patients unless the variation reported herein is considered. C-J Partsch, Institut für Reproduktionsmedizin, Westfälische Wilhelms-Universität, Steinfurter Straβe 107, D-48149 Münster, Germany

scholarly journals Propofol Protects against Ischemia/Reperfusion Injury Associated with Reduced Apoptosis in Rat Liver

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Ali F. Abdel-Wahab ◽  
Wahid M. Al-Harizy
Keyword(s):  
Caspase 3 ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Serum Levels ◽  
Group I ◽  
Cellular Apoptosis ◽  
Bax Gene ◽  
Hepatic Protection ◽  
Different Doses

Propofol is an intravenous anesthetic, reported to have a protective effect against ischemia/reperfusion (I/R) injury in heart and brain, but no definite data are available concerning its effect in hepatic I/R. This work investigated the effect of propofol anesthesia on hepatic I/R injury using in vivo rat model. Four groups of rats were included: sham operated, I/R (30 min ischemia and 2 h reperfusion), I/R treated with propofol (10 mg/kg/h), and I/R treated with propofol (20 mg/kg/h). Liver enzyme leakage, TNF-α and caspase-3 levels, and antiapoptotic Bcl-xL/apoptotic Bax gene expression, together with histopathological changes, were used to evaluate the extent of hepatic I/R injury. Compared with sham-operated group, I/R group showed significant increase in serum levels of liver enzymes (ALT, AST), TNF-α, and caspase-3 and significant decrease in the Bcl-xL/Bax ratio, associated with histopathologic damage in liver. Propofol infusion significantly attenuated these changes with reduced hepatic histopathologic lesions compared with nonpreconditioned I/R group. However, no significant differences were found between two groups treated with different doses of propofol. In conclusion, propofol infusion reduced hepatic I/R injury with decreased markers of cellular apoptosis. Therefore, propofol anesthesia may provide a useful hepatic protection during liver surgery.

scholarly journals Prolonged High Altitude Exposure Results in Elevated Erythroferrone and Diminished Hepcidin Levels in Healthy Young Male Volunteers

2017 ◽  
Vol 31 (S1) ◽  
Author(s):  
James P McClung ◽  
Stephen R. Hennigar ◽  
Claire E. Berryman ◽  
Andrew J. Young ◽  
Stefan M. Pasiakos
Keyword(s):  
High Altitude ◽  
Young Male ◽  
Altitude Exposure ◽  
Male Volunteers

scholarly journals Effect of Lepidium meyenii (Maca), a root with aphrodisiac and fertility-enhancing properties, on serum reproductive hormone levels in adult healthy men

2003 ◽  
Vol 176 (1) ◽  
pp. 163-168 ◽  
Author(s):  
GF Gonzales ◽  
A Cordova ◽  
K Vega ◽  
A Chung ◽  
A Villena ◽  
...  
Keyword(s):  
Serum Testosterone ◽  
Serum Levels ◽  
Reproductive Hormone ◽  
Double Blind ◽  
Healthy Men ◽  
Hormone Levels ◽  
Lepidium Meyenii ◽  
The Times ◽  
Changes Over Time ◽  
Different Doses

Lepidium meyenii (Maca) is a Peruvian hypocotyl that grows exclusively between 4000 and 4500 m in the central Andes. Maca is traditionally employed in the Andean region for its supposed aphrodisiac and/or fertility-enhancing properties. This study was a 12-week double-blind, placebo-controlled, randomized, parallel trial in which active treatment with different doses of Maca Gelatinizada was compared with a placebo. The study aimed to test the hypothesis that Maca has no effect on serum reproductive hormone levels in apparently healthy men when administered in doses used for aphrodisiac and/or fertility-enhancing properties. Men aged between 21 and 56 Years received 1500 mg or 3000 mg Maca. Serum levels of luteinizing hormone, follicle-stimulating hormone, prolactin, 17-alpha hydroxyprogesterone, testosterone and 17-beta estradiol were measured before and at 2, 4, 8 and 12 weeks of treatment with placebo or Maca (1.5 g or 3.0 g per day). Data showed that compared with placebo Maca had no effect on any of the hormones studied nor did the hormones show any changes over time. Multiple regression analysis showed that serum testosterone levels were not affected by treatment with Maca at any of the times studied (P, not significant). In conclusion, treatment with Maca does not affect serum reproductive hormone levels.

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