Influence of oestradiol on alpha2-adrenoceptor binding sites on intact platelets of young male volunteers

1987 ◽  
Vol 33 (2) ◽  
pp. 147-150
Author(s):  
I. W. Reimann ◽  
C. Britzelmeier ◽  
P. Haber ◽  
H. Wollmann ◽  
K. H. Antonin ◽  
...  
Keyword(s):  
Binding Sites ◽  
Young Male ◽  
Male Volunteers ◽  
Alpha2 Adrenoceptor

scholarly journals Semen Quality, Hormonal Levels, and Androgen Receptor Gene Polymorphisms in a Population of Young Male Volunteers from Two Different Regions of Poland

2015 ◽  
Vol 21 ◽  
pp. 2494-2504
Author(s):  
Marzena Kamieniczna ◽  
Monika Fraczek ◽  
Agnieszka Malcher ◽  
Natalia Rozwadowska ◽  
Anna Czernikiewicz ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Gene Polymorphisms ◽  
Semen Quality ◽  
Receptor Gene ◽  
Young Male ◽  
Androgen Receptor Gene ◽  
Male Volunteers ◽  
Receptor Gene Polymorphisms ◽  
Hormonal Levels

Variability of pulsatile luteinizing hormone secretion in young male volunteers

1994 ◽  
Vol 131 (3) ◽  
pp. 263-272 ◽  
Author(s):  
Carl-Joachim Partsch ◽  
Sievert Abrahams ◽  
Niels Herholz ◽  
Michael Peter ◽  
Johannes D Veldhuis ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Half Life ◽  
Hormone Secretion ◽  
Young Male ◽  
Interpulse Interval ◽  
Luteinizing Hormone Secretion ◽  
Individual Subject ◽  
Deconvolution Analysis ◽  
Pulse Detection ◽  
Male Volunteers

Partsch C-J, Abrahams S, Herholz N, Peter M, Veldhuis JD, Sippell WG. Variability of pulsatile luteinizing hormone secretion in young male volunteers. Eur J Endocrinol 1994;131:263–72. ISSN 0804–4643 Characteristics of spontaneous pulsatile luteinizing hormone secretion were compared in ten young healthy men in three 24-h profiles obtained at intervals of 14 days and 3 months. The ages of the volunteers ranged from 19 to 25 years, and heights and weights were within normal limits. Blood samples were taken at 10-min intervals and plasma luteinizing hormone (LH) was determined in the same immunoradiometric assay using monoclonal antibodies. Conventional pulse detection was carried out with PULSAR and CLUSTER programs. In addition, a simultaneous multiple parameter DECONVOLUTION was applied. As a group, no significant differences between the three profile series were found for any of the calculated parameters of LH concentration or LH secretion. However, most parameters showed low correlation coefficients between the three study periods, suggesting that substantial individual variations might contribute to the more reliable group results. Median coefficients of variation (cv) for the individual subject ranged from 9.7% (interpulse interval and endogenous half-life) to 37.7% (mass per burst). However, the maximal individual cv observed was 78.4%. Intra-individual variability was lower than the variability between subjects for quantitative properties of LH concentration and secretion, although not significantly so for all parameters. In conventional pulse detection, the highest individual reliability was found for mean and integrated LH concentrations (median cv 10.2 and 13.7%, respectively), number of pulses per 24 h (CLUSTER, median cv 12.2%), mean pulse amplitude (PULSAR, median cv 10%) and interpulse interval (CLUSTER, median cv 9.7%). In DECONVOLUTION analysis, the endogenous LH half-life (median cv 9.7%), secretory burst amplitude (median cv 14.8%) and interburst interval (median cv 14.5%) revealed the lowest intra-individual variation. In contrast, the half-duration of a secretory episode and the mass of LH secreted per burst proved to be the least reliable measures (median cv 32.7% and 37.7%, respectively). Calculated endogenous LH production rates correlated highly (p < 0.01) across all three sessions. The relative frequencies of the LH peak amplitudes/heights and peak widths (durations) showed almost identical distribution curves for all three sampling periods. In conclusion, a high reproducibility of group results for both integrative parameters and pulse characteristics of LH concentrations and secretion were found in normal men. However, intra-individual reliability was variable and at times considerable, depending on the parameter chosen. These observations suggest caution in the interpretation of single LH profiles from individual subjects or patients unless the variation reported herein is considered. C-J Partsch, Institut für Reproduktionsmedizin, Westfälische Wilhelms-Universität, Steinfurter Straβe 107, D-48149 Münster, Germany

scholarly journals Prolonged High Altitude Exposure Results in Elevated Erythroferrone and Diminished Hepcidin Levels in Healthy Young Male Volunteers

2017 ◽  
Vol 31 (S1) ◽  
Author(s):  
James P McClung ◽  
Stephen R. Hennigar ◽  
Claire E. Berryman ◽  
Andrew J. Young ◽  
Stefan M. Pasiakos
Keyword(s):  
High Altitude ◽  
Young Male ◽  
Altitude Exposure ◽  
Male Volunteers

scholarly journals Corticosteroid-binding globulin in experimental hypothyroidism in male and female rats

2000 ◽  
Vol 46 (5) ◽  
pp. 35-39
Author(s):  
L. I. Nadolnik ◽  
N. V. Emelyanov ◽  
I. P. Pasteur ◽  
V. V. Vinogradov
Keyword(s):  
Biological Activity ◽  
Thyroid Hormones ◽  
Binding Sites ◽  
Young Male ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats ◽  
Corticosteroid Binding Globulin ◽  
Daily Dose

Main parameters of complex formation of corticosteroid-binding globulin (CSG) were studied in young male and female rats with hypothyrosis induced by mercasolyl in a daily dose of 6 and 30 mg/kg. No pronounced differences in CSG, typical of adult animals, were observed in young rats under conditions of thyroid function inhibition. Steroidand androgen-inhibitory and estrogen-inducing effects of hormones towards CSG did not manifest in hypothyrosis. Decrease in the level of thyroid hormones is characterized by increased affinity of CSG for glucocorticoids and a decrease in the concentration of binding sites. These data indicate that thyroid hormones are the primary regulators of CSG activity. Possibility of modifying CSG affinity and role of this factor in regulation of biological activity of glucocorticoids are discussed.

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