scholarly journals Effect of Lepidium meyenii (Maca), a root with aphrodisiac and fertility-enhancing properties, on serum reproductive hormone levels in adult healthy men

2003 ◽  
Vol 176 (1) ◽  
pp. 163-168 ◽  
Author(s):  
GF Gonzales ◽  
A Cordova ◽  
K Vega ◽  
A Chung ◽  
A Villena ◽  
...  
Keyword(s):  
Serum Testosterone ◽  
Serum Levels ◽  
Reproductive Hormone ◽  
Double Blind ◽  
Healthy Men ◽  
Hormone Levels ◽  
Lepidium Meyenii ◽  
The Times ◽  
Changes Over Time ◽  
Different Doses

Lepidium meyenii (Maca) is a Peruvian hypocotyl that grows exclusively between 4000 and 4500 m in the central Andes. Maca is traditionally employed in the Andean region for its supposed aphrodisiac and/or fertility-enhancing properties. This study was a 12-week double-blind, placebo-controlled, randomized, parallel trial in which active treatment with different doses of Maca Gelatinizada was compared with a placebo. The study aimed to test the hypothesis that Maca has no effect on serum reproductive hormone levels in apparently healthy men when administered in doses used for aphrodisiac and/or fertility-enhancing properties. Men aged between 21 and 56 Years received 1500 mg or 3000 mg Maca. Serum levels of luteinizing hormone, follicle-stimulating hormone, prolactin, 17-alpha hydroxyprogesterone, testosterone and 17-beta estradiol were measured before and at 2, 4, 8 and 12 weeks of treatment with placebo or Maca (1.5 g or 3.0 g per day). Data showed that compared with placebo Maca had no effect on any of the hormones studied nor did the hormones show any changes over time. Multiple regression analysis showed that serum testosterone levels were not affected by treatment with Maca at any of the times studied (P, not significant). In conclusion, treatment with Maca does not affect serum reproductive hormone levels.

scholarly journals Effect ofLepidium meyeniiWalp. on Semen Parameters and Serum Hormone Levels in Healthy Adult Men: A Double-Blind, Randomized, Placebo-Controlled Pilot Study

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Ingrid Melnikovova ◽  
Tomas Fait ◽  
Michaela Kolarova ◽  
Eloy C. Fernandez ◽  
Luigi Milella
Keyword(s):  
Healthy Adult ◽  
Pilot Trial ◽  
Sperm Concentration ◽  
Medical Intervention ◽  
Semen Parameters ◽  
Double Blind ◽  
Hormone Levels ◽  
Lepidium Meyenii ◽  
Adult Men ◽  
Serum Hormone

Background/Aims.Products ofLepidium meyeniiWalp. (maca) are touted worldwide as an alimentary supplement to enhance fertility and restore hormonal balance. Enhancing properties of maca on semen parameters in animals were previously reported by various authors, but we present to the best of our knowledge the first double-blind, randomized, placebo-controlled pilot trial in men. The aim of this study was to evaluate the effects of maca on semen parameters and serum hormone levels in healthy adult men.Methods.A group of 20 volunteers aged 20–40 years was supplied by milled hypocotyl of maca or placebo (1.75 g/day) for 12 weeks. Negative controls of semen were compared to the samples after 6 and 12 weeks of maca administration; negative blood controls were compared to the samples after 12 weeks of treatment.Results.Sperm concentration and motility showed rising trends compared to placebo even though levels of hormones did not change significantly after 12 weeks of trial.Conclusion.Our results indicate that maca possesses fertility enhancing properties in men. As long as men prefer to use alimentary supplement to enhance fertility rather than prescribed medication or any medical intervention, it is worth continuing to assess its possible benefits.

scholarly journals Randomized, double blind, placebo controlled clinical study to assess efficacy and safety of NRL/MW/201901 in subjects suffering from erectile dysfunction

2020 ◽  
Vol 11 (3) ◽  
pp. 2790-2801
Author(s):  
Omkar Kulkarni ◽  
Anuj Agarwal ◽  
Priya Khare ◽  
Gayatri Ganu
Keyword(s):  
Quality Of Life ◽  
Erectile Dysfunction ◽  
Holistic Approach ◽  
Serum Testosterone ◽  
Well Being ◽  
Serum Levels ◽  
Treated Group ◽  
Double Blind ◽  
Resting Metabolism

Sex is an integral part of a well-being. Sexual satisfaction is the most important component of the quality of life. In management of ED overall sexual potential and quality of life needs to be taken care of as a holistic approach to management. The aim of the study was to clinically validate effect of NRL/MW/201901 a polyhedral Nutraceutical product in ED. The clinical efficacy of NRL/MW/201901 in patients suffering from erectile dysfunction was evaluated by assessing Quality of Erection Questionnaire and sexual encounter profile with Intra-vaginal ejaculation latency time, serum testosterone and anthropometric analysis etc. NRL/MW/201901 was effective in increasing erection function, orgasmic function, intercourse satisfaction, overall satisfaction and sexual desire. There is marked increase in number of sexual encounters in NRL/MW/201901 treated group. Serum levels of testosterone were increased after treatment of NRL/MW/201901 than in placebo group. It was evident from the anthropometric analysis of the subjects that there was significant increase in resting metabolism and % skeletal muscle content in NRL/MW/201901 treated group. There were no evident adverse events related to drug. Thus it could be concluded that NRL/MW/201901 is safe and effective in the treatment of mild to moderate erectile dysfunction.

Characterization of a prospective human model for study of the reproductive hormone responses to major illness

2008 ◽  
Vol 295 (1) ◽  
pp. E63-E69 ◽  
Author(s):  
Daniel I. Spratt ◽  
Robert S. Kramer ◽  
Jeremy R. Morton ◽  
F. Lee Lucas ◽  
Karen Becker ◽  
...  
Keyword(s):  
Animal Studies ◽  
Time Course ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Serum Testosterone ◽  
Serum Levels ◽  
Reproductive Hormones ◽  
Human Model ◽  
Reproductive Hormone ◽  
Cabg Surgery

With critical illness, serum testosterone levels fall markedly, whereas estrogen levels rise. Although animal studies suggest adaptive advantages, no prospective model has been available for studies in humans. We hypothesized that coronary artery bypass graft (CABG) surgery would provide such a model by eliciting the same reproductive hormone and other endocrine responses as reported with major nonsurgical illnesses. We further hypothesized that those responses would occur consistently in all CABG patients with predictable time courses, providing reliable windows for prospective studies. In 17 men undergoing CABG, serum levels of reproductive hormones, cortisol, thyroid hormones, and IGF-I were measured before and for up to 5 wk after surgery. Changes in serum levels of reproductive and other hormones were similar to those reported in nonsurgical critically ill patients. Time course for onset, duration, and recovery of reproductive hormone changes were consistent among all patients. A window for studying the testosterone and estrogen responses was established as the first 5 days following CABG. Practical use of this model was demonstrated by evaluating, in another seven men, changes in gonadotroph responsiveness to GnRH following CABG. Finally, to determine whether our findings in CABG could be extended to other surgeries, we demonstrated similar endocrine responses in 12 men following abdominal aortic aneurysm resection. We conclude that patients undergoing CABG surgery provide a useful human model for the prospective evaluation of the reproductive axis responses to acute illness. Other major surgeries are likely to also be suitable for these studies.

Effect of Lepidium meyenii (MACA) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men

Andrologia ◽  
2002 ◽  
Vol 34 (6) ◽  
pp. 367-372 ◽  
Author(s):  
G. F. Gonzales ◽  
A. Cordova ◽  
K. Vega ◽  
A. Chung ◽  
A. Villena ◽  
...  
Keyword(s):  
Sexual Desire ◽  
Serum Testosterone ◽  
Healthy Men ◽  
Testosterone Levels ◽  
Lepidium Meyenii

scholarly journals Pharmacokinetics, safety and tolerability of three dosage regimens of buccal adhesive testosterone tablets in healthy men suppressed with leuprorelin

2002 ◽  
Vol 175 (3) ◽  
pp. 813-819 ◽  
Author(s):  
KJ Baisley ◽  
MJ Boyce ◽  
S Bukofzer ◽  
R Pradhan ◽  
SJ Warrington
Keyword(s):  
Circadian Variation ◽  
Serum Testosterone ◽  
Free Testosterone ◽  
Crossover Design ◽  
Normal Range ◽  
Double Blind ◽  
Healthy Men ◽  
Leuprorelin Acetate ◽  
Dosage Regimens ◽  
Dose Proportional

We used a randomised, double-blind, crossover design to evaluate the pharmacokinetics, safety and tolerability of three doses of buccal adhesive testosterone tablets (BATT). Twenty-four healthy men, whose endogenous testosterone was suppressed to </=5.38 nmol/l with leuprorelin acetate, took BATT (10, 20 or 30 mg) daily for 10 days. There was a 4-day washout between treatments. Substantial testosterone absorption occurred from BATT, and mean serum testosterone, free testosterone and dihydrotestosterone (DHT) concentrations over 24 h showed circadian variation. Steady state was reached by day 5. Average 24-h concentrations for the three BATT doses were within the normal range for eugonadal men: testosterone 11.67-14.57 nmol/l, free testosterone 0.026-0.33 nmol/l and DHT 1.66-2.03 nmol/l. On all three doses, peak testosterone and free testosterone was reached 8-9 h after tablet application; DHT peaked about 1-2 h later, and declined more slowly. Hormone concentrations increased with BATT dose, but increases were less than dose-proportional. There was no evidence of testosterone accumulation. BATT was well tolerated.

scholarly journals Serum Reproductive hormone levels in male symptomatic HIV/AIDS patients on Antiretroviral therapy negative to Malaria parasite in Nnewi, Anambra State, Nigeria

2019 ◽  
Vol 10 (3) ◽  
pp. 44-49
Author(s):  
Priscilla Ifeoma Ezeugwunne ◽  
Chukwuemeka Emmanuel Ogbodo ◽  
Adamma Rosemary Analike ◽  
Nwando Chikaodili Obi-Ezeani ◽  
Joy Ifeoma Onuora ◽  
...  
Keyword(s):  
Malaria Parasite ◽  
Serum Levels ◽  
Hiv Positive ◽  
Reproductive Hormone ◽  
Infected Male ◽  
Hormone Levels ◽  
Anambra State ◽  
Male Subjects ◽  
Asymptomatic Hiv ◽  
Hiv Aids

Background: AIDS is an endemic disease that causes death among young adults worldwide especially in Nigeria. Aims and Objectives: This study investigated the serum reproductive hormone levels in symptomatic HIV/AIDS male subjects on ART who are negative to malaria parasite in Nnewi, Anambra State, Nigeria. Materials and Methods: A total of 274 adult male participants aged between 18 and 60 years were randomly recruited, and grouped into: symptomatic HIV (stage 11) infected male participants on ART (A: n=69), Symptomatic HIV subjects not on ART (B: n= 69), Asymptomatic HIV positive subjects (C: n= 68) and HIV seronegative subjects (D: n= 68). Serum was used to assay for PSA, LH, FSH, Estrogen, Testosterone, Progesterone and Prolactin levels. Analysis of variance and student t-test were used for data analyses. Results: The serum levels of PSA, FSH, Estrogen, Testosterone, Progesterone and Prolactin were significantly different amongst the groups at p<0.05 respectively. There were significantly higher levels of PSA, Estrogen, Progesterone but lower levels of Testosterone and Prolactin in subjects on ART compared with control at p<0.05 respectively. There were significantly higher levels of PSA, FSH, Estrogen,Progesterone but lower levels of Testosterone in subjects not on ART compared with control at p<0.05 respectively. Conclusion: The reduction on serum levels of Testosterone and higher levels in FSH, PSA, Estrogen, and Progesterone may reveal presence of hypogonadism, primary testicular failure, prostate abnormalities such as cancer and hyperprogesteronaemia, in symptomatic HIV positives.

scholarly journals Evaluation of the Impact of Different Doses of Curcuma longa L. on Antioxidant Capacity: A Randomized, Double-Blind, Crossover Pilot Trial

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Tatyanne Letícia N. Gomes ◽  
Renata Santos S. Zenha ◽  
Alisson H. Antunes ◽  
Flávia R. Faria ◽  
Kênnia R. Rezende ◽  
...  
Keyword(s):  
Antioxidant Capacity ◽  
Low Dose ◽  
Curcuma Longa ◽  
Pilot Trial ◽  
Bioactive Compound ◽  
High Dose ◽  
Double Blind ◽  
Healthy Men ◽  
The Impact ◽  
Different Doses

Curcumin is a bioactive compound derived from Curcuma longa L. root, extensively studied due to its antioxidant and anti-inflammatory properties. This study evaluates the effects of different doses of powdered C. longa root on antioxidant capacity in healthy men. In a pilot randomized, double-blinded, crossover experiment, we acutely administered a low dose (1.5 g, LCG), moderate dose (3.0 g, MCG), and high dose (6.0 g, HCG) of C. longa to nine healthy men. There were no differences in plasma curcumin levels ( p = 0.593 ) and antioxidant capacity ( p = 0.473 ) for time × group interactions. Plasma curcumin levels increased in all groups after 20 and 90 min of C. longa intake ( p < 0.05 ). HCG had a lower postprandial incremental area under the antioxidant capacity curve than LCG or MCG ( p < 0.01 ). A low dose of C. longa increased the antioxidant capacity in healthy men. However, plasma curcumin levels were not dose dependently affected.

scholarly journals Estrogen Replacement Therapy in a Man with Congenital Aromatase Deficiency: Effects of Different Doses of Transdermal Estradiol on Bone Mineral Density and Hormonal Parameters

2000 ◽  
Vol 85 (5) ◽  
pp. 1841-1845 ◽  
Author(s):  
Vincenzo Rochira ◽  
Marco Faustini-Fustini ◽  
Antonio Balestrieri ◽  
Cesare Carani
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Study Protocol ◽  
Phase 1 ◽  
Serum Testosterone ◽  
Serum Levels ◽  
Mineral Density ◽  
Phase 3 ◽  
Transdermal Estradiol ◽  
Different Doses

Abstract The effects of different doses of transdermal estradiol (TE) on bone mineral density (BMD) in a man with aromatase deficiency were evaluated. The study protocol was divided in the following four phases: phase 1, before estradiol treatment; phase 2, 50 μg TE twice weekly for 6 months; phase 3, 25 μg TE twice weekly for 9 months; and phase 4, 12.5 μg TE twice weekly for 9 months. X-rays of hands, legs, and pelvis were performed, and BMD of the lumbar spine, hormonal parameters (LH, FSH, testosterone, and estradiol), and markers of bone turnover were determined during each phase. BMD in phase 1 was 0.933 g/cm2 and increased to 1.051 and 1.173 g/cm2 after 4 and 7 months of TE, respectively. In phase 3, BMD reached the maximum value (1.275 g/cm2). In phase 4, BMD decreased to 1.180 g/cm2 and was 1.029 g/cm2 at the end of the study protocol. A bilateral necrosis of femoral heads was also detected by x-ray films. In phase 1 serum testosterone was in the normal range, whereas serum estradiol was undetectable. During the 24-month period of treatment with TE (phases 2–4), estradiol was directly related to the amount of TE, whereas LH was inversely related to estradiol serum levels. Estradiol and gonadotropins reached optimal values only in phase 3, when FSH also was near normal; serum testosterone concentrations were normal in phases 3 and 4. This study confirms the role of estrogens in achieving and maintaining bone mineral content in the human male, providing further clinical tools useful in the management of bone loss in aromatase deficiency in the male. We suggest that the adequate substitutive dose of TE for maintaining both bone mass and normal estradiol serum levels in adult men with aromatase deficiency may be 25 μg twice weekly (0.47 μg/kg weekly).

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