HEALTH-FOOD SUPPLEMENT N,N-DIMETHYLGLYCINE CONTROLS SEIZURE ACTIVITY

InPharma ◽  
1982 ◽  
Vol 364 (1) ◽  
pp. 13-13
2007 ◽  
Vol 51 (9) ◽  
pp. 861-873 ◽  
Author(s):  
Nobunao Ikewaki ◽  
Noboru Fujii ◽  
Takashi Onaka ◽  
Shinichiro Ikewaki ◽  
Hidetoshi Inoko
Keyword(s):  

2001 ◽  
Vol 100 (6) ◽  
pp. 627 ◽  
Author(s):  
Raymond J. PLAYFORD ◽  
Christopher E. MACDONALD ◽  
Denis P. CALNAN ◽  
David N. FLOYD ◽  
Theo PODAS ◽  
...  

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
EunChae Ryu ◽  
Ji Sung Park ◽  
Sib Sankar Giri ◽  
Se Chang Park

Soft-shell turtle (SST; freshwater terrapin or tortoise) is a popular and important health functional food (HFF) product in many Asian countries. HFFs containing SST must be safe, but several HFFs have been found to be contaminated with dangerous substances, such as nitrofuran metabolites (NFMs). This finding suggests that the consumption of HFFs results in the regular exposure of vulnerable individuals to hazardous substances. Importantly, nitrofuran antibiotics have been banned for use in food-producing animals since the 1990s by the European Union. Thus, in this study, we propose a reliable and quick method to reduce the time required for the detection of four NFMs in SST powder that conventional methods are unable to quantify. Our method involves the derivatization and hydrolysis of SST powder and was validated in accordance with the requirements of European Commission Decision 2002/657/EC. The method achieves an apparent mean recovery of 82.2–108.1%, repeatability of 1.5–3.8%, and reproducibility of 2.2–4.8% for 0.5–10.0 μg kg−1 of 1-aminohydantoin, semicarbazide, 3-amino-2-oxazolidinone, and 3-amino-5-morpholinomethyl-2-oxazolidinone. In addition, linearity was achieved with correlation coefficients of 0.999, and the detection capability (CCβ) and decision limit (CCα) were found to be reliable, indicating that this is a fast and accurate method for the analysis of SST powder. The validated method was successfully applied to detect NFMs in SST powder in commercial HHFs.


2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Sherry L. Xu ◽  
Cathy W. C. Bi ◽  
Roy C. Y. Choi ◽  
Kevin Y. Zhu ◽  
Abudureyimu Miernisha ◽  
...  

Neurotrophic factors are playing vital roles in survival, growth, and function of neurons. Regulation of neurotrophic factors in the brain has been considered as one of the targets in developing drug or therapy against neuronal disorders. Flavonoids, a family of multifunctional natural compounds, are well known for their neuronal beneficial effects. Here, the effects of flavonoids on regulating neurotrophic factors were analyzed in cultured rat astrocytes. Astrocyte is a major secreting source of neurotrophic factors in the brain. Thirty-three flavonoids were screened in the cultures, and calycosin, isorhamnetin, luteolin, and genistein were identified to be highly active in inducing the synthesis and secretion of neurotrophic factors, including nerve growth factor (NGF), glial-derived neurotrophic factor (GDNF), and brain-derived neurotrophic factor (BDNF). The inductions were in time- and dose-dependent manners. In cultured astrocytes, the phosphorylation of estrogen receptor was triggered by application of flavonoids. The phosphorylation was blocked by an inhibitor of estrogen receptor, which in parallel reduced the flavonoid-induced expression of neurotrophic factors. The results proposed the role of flavonoids in protecting brain diseases, and therefore these flavonoids could be developed for health food supplement for patients suffering from neurodegenerative diseases.


2015 ◽  
Vol 05 (04) ◽  
pp. 262-274 ◽  
Author(s):  
Gallant Kar Lun Chan ◽  
Zack Chun Fai Wong ◽  
Kelly Yin Ching Lam ◽  
Lily Kwan Wai Cheng ◽  
Laura Minglu Zhang ◽  
...  

Gut ◽  
1999 ◽  
Vol 44 (5) ◽  
pp. 653-658 ◽  
Author(s):  
R J Playford ◽  
D N Floyd ◽  
C E Macdonald ◽  
D P Calnan ◽  
R O Adenekan ◽  
...  

BACKGROUNDNon-steroidal anti-inflammatory drugs (NSAIDs) are effective for arthritis but cause gastrointestinal injury. Bovine colostrum is a rich source of growth factors and is marketed as a health food supplement.AIMSTo examine whether spray dried, defatted colostrum or milk preparations could reduce gastrointestinal injury caused by indomethacin.METHODSEffects of test solutions, administered orally, were examined using an indomethacin restraint rat model of gastric damage and an indomethacin mouse model of small intestinal injury. Effects on migration of the human colonic carcinoma cell line HT-29 and rat small intestinal cell line RIE-1 were assessed using a wounded monolayer assay system (used as an in vitro model of wound repair) and effects on proliferation determined using [3H]thymidine incorporation.RESULTSPretreatment with 0.5 or 1 ml colostral preparation reduced gastric injury by 30% and 60% respectively in rats. A milk preparation was much less efficacious. Recombinant transforming growth factor β added at a dose similar to that found in the colostrum preparation (12.5 ng/rat), reduced injury by about 60%. Addition of colostrum to drinking water (10% vol/vol) prevented villus shortening in the mouse model of small intestinal injury. Addition of milk preparation was ineffective. Colostrum increased proliferation and cell migration of RIE-1 and HT-29 cells. These effects were mainly due to constituents of the colostrum with molecular weights greater than 30 kDa.CONCLUSIONSBovine colostrum could provide a novel, inexpensive approach for the prevention and treatment of the injurious effects of NSAIDs on the gut and may also be of value for the treatment of other ulcerative conditions of the bowel.


Author(s):  
K. K. Dave ◽  
Rachna Paliwal

Healthy living is prime concern of today’s society. Many studies show that people are adopting health related changes in their eating habits. These changes create a new opportunity in food and drink industry. This is the reason health drink industry emerged as the most popular and growing segment of overall soft drinks industry in the world. As compared to the other food supplement health drinks stands the top in position, because these drinks have no side effects. There is enormous competition in between various international brands of health food drink companies. They are coming with new products and strategies. Malted health food drink is among best substitute of a complete food. India, the world’s largest malt bases drinks market accounts for 22% of the world’s retail volume sales. These drinks are traditionally consumed as milk substitutes and also available in mixed with water and marketed as nutritious drinks mainly consumed by the old, the young and the sick persons. Malt is germinated cereal grains that have been dried in a process known as malting. The grains are made to germinate by soaking in water, and are then halted from germinating further by drying with hot air. This paper is designed is such a way where perception of consumers about malted health food drinks are not only explained in details but also tested through proper application of statistical tools.


2001 ◽  
Vol 100 (6) ◽  
pp. 627-633 ◽  
Author(s):  
Raymond J. PLAYFORD ◽  
Christopher E. MACDONALD ◽  
Denis P. CALNAN ◽  
David N. FLOYD ◽  
Theo PODAS ◽  
...  

Non-steroidal anti-inflammatory drugs (NSAIDs) are effective analgesics but cause gastrointestinal injury. Present prophylactic measures are suboptimal and novel therapies are required. Bovine colostrum is a cheap, readily available source of growth factors, which reduces gastrointestinal injury in rats and mice. We therefore examined whether spray-dried, defatted colostrum could reduce the rise in gut permeability (a non-invasive marker of intestinal injury) caused by NSAIDs in volunteers and patients taking NSAIDs for clinical reasons. Healthy male volunteers (n = 7) participated in a randomized crossover trial comparing changes in gut permeability (lactulose/rhamnose ratios) before and after 5 days of 50 mg of indomethacin three times daily (tds) per oral with colostrum (125 ml, tds) or whey protein (control) co-administration. A second study examined the effect of colostral and control solutions (125 ml, tds for 7 days) on gut permeability in patients (n = 15) taking a substantial, regular dose of an NSAID for clinical reasons. For both studies, there was a 2 week washout period between treatment arms. In volunteers, indomethacin caused a 3-fold increase in gut permeability in the control arm (lactulose/rhamnose ratio 0.36±0.07 prior to indomethacin and 1.17±0.25 on day 5, P < 0.01), whereas no significant increase in permeability was seen when colostrum was co-administered. In patients taking long-term NSAID treatment, initial permeability ratios were low (0.13±0.02), despite continuing on the drug, and permeability was not influenced by co-administration of test solutions. These studies provide preliminary evidence that bovine colostrum, which is already currently available as an over-the-counter preparation, may provide a novel approach to the prevention of NSAID-induced gastrointestinal damage in humans.


Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 609
Author(s):  
Karen S. Bishop

Fomitopsis pinicola (Sw. Karst) is a common bracket fungus, with a woody texture. It is found predominantly in coniferous forests in temperate regions throughout Europe and Asia. Fomitopsis pinicola has been extensively used for medicinal purposes, particularly in Chinese and Korean traditional medicine. In this mini-review, the anti-cancer characteristics of F. pinicola extracts were investigated. In vitro experiments revealed the pro-apoptotic, anti-oxidant and anti-inflammatory properties of extracts, whilst two of three in vivo studies reported an inhibition of tumour growth and prolonged survival. Only studies wherein fungal specimens were sourced from Europe or Asia were included in this review, as samples sourced as F. pinicola from North America were probably not F. pinicola, but a different species. Although not one of the most revered fungal species, F. pinicola has been used as a medicinal fungus for centuries, as well as consumed as a health food supplement. To date, the results from only three in vivo studies, investigating anti-cancer properties, have been published. Further studies, using comprehensively identified specimens, are required to fully elucidate the anti-cancer properties of F. pinicola extracts.


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