Co-administration of the health food supplement, bovine colostrum, reduces the acute non-steroidal anti-inflammatory drug-induced increase in intestinal permeability

2001 ◽  
Vol 100 (6) ◽  
pp. 627 ◽  
Author(s):  
Raymond J. PLAYFORD ◽  
Christopher E. MACDONALD ◽  
Denis P. CALNAN ◽  
David N. FLOYD ◽  
Theo PODAS ◽  
...  
Keyword(s):  
Intestinal Permeability ◽  
Food Supplement ◽  
Bovine Colostrum ◽  
Health Food ◽  
Drug Induced ◽  
Inflammatory Drug ◽  
Anti Inflammatory

Co-administration of the health food supplement, bovine colostrum, reduces the acute non-steroidal anti-inflammatory drug-induced increase in intestinal permeability

2001 ◽  
Vol 100 (6) ◽  
pp. 627-633 ◽  
Author(s):  
Raymond J. PLAYFORD ◽  
Christopher E. MACDONALD ◽  
Denis P. CALNAN ◽  
David N. FLOYD ◽  
Theo PODAS ◽  
...  
Keyword(s):  
Fold Increase ◽  
Preliminary Evidence ◽  
Food Supplement ◽  
Bovine Colostrum ◽  
Gut Permeability ◽  
Health Food ◽  
Drug Induced ◽  
Gastrointestinal Injury ◽  
Prophylactic Measures ◽  
Anti Inflammatory

Non-steroidal anti-inflammatory drugs (NSAIDs) are effective analgesics but cause gastrointestinal injury. Present prophylactic measures are suboptimal and novel therapies are required. Bovine colostrum is a cheap, readily available source of growth factors, which reduces gastrointestinal injury in rats and mice. We therefore examined whether spray-dried, defatted colostrum could reduce the rise in gut permeability (a non-invasive marker of intestinal injury) caused by NSAIDs in volunteers and patients taking NSAIDs for clinical reasons. Healthy male volunteers (n = 7) participated in a randomized crossover trial comparing changes in gut permeability (lactulose/rhamnose ratios) before and after 5 days of 50 mg of indomethacin three times daily (tds) per oral with colostrum (125 ml, tds) or whey protein (control) co-administration. A second study examined the effect of colostral and control solutions (125 ml, tds for 7 days) on gut permeability in patients (n = 15) taking a substantial, regular dose of an NSAID for clinical reasons. For both studies, there was a 2 week washout period between treatment arms. In volunteers, indomethacin caused a 3-fold increase in gut permeability in the control arm (lactulose/rhamnose ratio 0.36±0.07 prior to indomethacin and 1.17±0.25 on day 5, P < 0.01), whereas no significant increase in permeability was seen when colostrum was co-administered. In patients taking long-term NSAID treatment, initial permeability ratios were low (0.13±0.02), despite continuing on the drug, and permeability was not influenced by co-administration of test solutions. These studies provide preliminary evidence that bovine colostrum, which is already currently available as an over-the-counter preparation, may provide a novel approach to the prevention of NSAID-induced gastrointestinal damage in humans.

scholarly journals Involvement of gliadin, a component of wheat gluten, in increased intestinal permeability leading to non-steroidal anti-inflammatory drug-induced small-intestinal damage

PLoS ONE ◽  
2019 ◽  
Vol 14 (2) ◽  
pp. e0211436 ◽  
Author(s):  
Sunao Shimada ◽  
Tetsuya Tanigawa ◽  
Toshio Watanabe ◽  
Akinobu Nakata ◽  
Naoki Sugimura ◽  
...  
Keyword(s):  
Intestinal Permeability ◽  
Wheat Gluten ◽  
Intestinal Damage ◽  
Drug Induced ◽  
Inflammatory Drug ◽  
Small Intestinal ◽  
Anti Inflammatory

Non Steroidal Anti-Inflammatory Drug Induced Damage on Lower Gastro-Intestinal Tract: Is There an Involvement of Microbiota?

2014 ◽  
Vol 9 (3) ◽  
pp. 196-204 ◽  
Author(s):  
Lucia Montenegro ◽  
Giuseppe Losurdo ◽  
Raffaele Licinio ◽  
Maria Zamparella ◽  
Floriana Giorgio ◽  
...  
Keyword(s):  
Intestinal Tract ◽  
Drug Induced ◽  
Inflammatory Drug ◽  
Anti Inflammatory ◽  
Gastro Intestinal Tract

scholarly journals Back Pain and Radiculopathy from Non-Steroidal Anti-Inflammatory Drug-induced Dorsal Epidural Haematoma

2019 ◽  
Vol 12 (3) ◽  
pp. e229015 ◽  
Author(s):  
Jaime L Martinez Santos ◽  
Mohammed Alshareef ◽  
Stephen P Kalhorn
Keyword(s):  
Back Pain ◽  
Epidural Haematoma ◽  
Drug Induced ◽  
Inflammatory Drug ◽  
Anti Inflammatory

Non-Steroidal Anti-Inflammatory Drug-Induced Gastropathy

1989 ◽  
Vol 4 (2) ◽  
pp. 77-94 ◽  
Author(s):  
S. Szabo ◽  
W. F. Spill ◽  
K. D. Rainsford
Keyword(s):  
Drug Induced ◽  
Inflammatory Drug ◽  
Anti Inflammatory
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