Pharmacokinetics of a novelN-methyl-D-aspartate receptor antagonist (SM-18400): Identification of anN-acetylated metabolite and pre-clinical assessment ofN-acetylation polymorphism

2003 ◽  
Vol 28 (1) ◽  
pp. 21-29 ◽  
Author(s):  
Masashi Yabuki ◽  
Yutaka Kon-Ya ◽  
Masaki Kataoka ◽  
Takeshi Shimizudani ◽  
Kyoko Akao ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Clinical Assessment ◽  
Acetylation Polymorphism ◽  
Aspartate Receptor

Metabolism, Distribution and Excretion of a Selective N-Methyl-d-Aspartate Receptor Antagonist, Traxoprodil, in Rats and Dogs

2007 ◽  
Vol 35 (8) ◽  
pp. 1350-1364 ◽  
Author(s):  
Chandra Prakash ◽  
Donghui Cui ◽  
Michael J. Potchoiba ◽  
Todd Butler
Keyword(s):  
Receptor Antagonist ◽  
Aspartate Receptor

scholarly journals Combination Therapy in Moderate to Severe Alzheimer’s Disease - Overview and Discussion Points for the Future

2011 ◽  
Vol 6 (4) ◽  
pp. 228
Author(s):  
José L Molinuevo ◽  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Combination Therapy ◽  
Receptor Antagonist ◽  
Cholinesterase Inhibitors ◽  
Current Data ◽  
Aspartate Receptor ◽  
The Future

Two effective symptomatic therapies are available for Alzheimer’s disease: the cholinesterase inhibitors (ChEIs) and memantine, an N-methyl-D-aspartate receptor antagonist. Current data demonstrate that combination therapy with memantine and a ChEI produces symptomatic benefits in all domains of AD. The benefits of combination therapy are greater than those of ChEI monotherapy, are sustained long term and appear to increase with time.

EFFECT OF N-METHYL-D-ASPARTATE RECEPTOR ANTAGONIST ON RADIATION-INDUCED GUT INJURIES IN MICE

2017 ◽  
Author(s):  
Masatsugu Ohgami ◽  
Nobuhiko Takai ◽  
Masahiko Watanabe ◽  
Koichi Ando ◽  
Akiko Uzawa ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Aspartate Receptor ◽  
Radiation Induced

Action of the N-Methyl-D-Aspartate Receptor Antagonist MK-801 against Focal Seizure Activity from the Feline Hippocampus

1992 ◽  
Vol 26 (4) ◽  
pp. 205-209 ◽  
Author(s):  
Yuji Wada ◽  
Hidehiro Hasegawa ◽  
Mitsuhiko Nakamura ◽  
Nariyoshi Yamaguchi
Keyword(s):  
Receptor Antagonist ◽  
Seizure Activity ◽  
Focal Seizure ◽  
Mk 801 ◽  
Aspartate Receptor
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