Action of the N-Methyl-D-Aspartate Receptor Antagonist MK-801 against Focal Seizure Activity from the Feline Hippocampus

1992 ◽  
Vol 26 (4) ◽  
pp. 205-209 ◽  
Author(s):  
Yuji Wada ◽  
Hidehiro Hasegawa ◽  
Mitsuhiko Nakamura ◽  
Nariyoshi Yamaguchi
Keyword(s):  
Receptor Antagonist ◽  
Seizure Activity ◽  
Focal Seizure ◽  
Mk 801 ◽  
Aspartate Receptor

Peripheral administration of an N-methyl-d -aspartate receptor antagonist (MK-801) changes dorsal horn neuronal responses in rats

1999 ◽  
Vol 260 (2) ◽  
pp. 89-92 ◽  
Author(s):  
Takahiro Ushida ◽  
Toshikazu Tani ◽  
Motohiro Kawasaki ◽  
Osamu Iwatsu ◽  
Hiroshi Yamamoto
Keyword(s):  
Receptor Antagonist ◽  
Dorsal Horn ◽  
Neuronal Responses ◽  
Mk 801 ◽  
Aspartate Receptor

The N-methyl-d-aspartate receptor antagonist MK-801 delays the onset of puberty and may acutely block the first spontaneous LH surge and ovulation in the rat

1991 ◽  
Vol 131 (3) ◽  
pp. 435-441 ◽  
Author(s):  
H. M. A. Meijs-Roelofs ◽  
P. Kramer ◽  
E. C. M. van Leeuwen
Keyword(s):  
Nmda Receptors ◽  
Receptor Antagonist ◽  
Acute Treatment ◽  
Physiological Role ◽  
Female Rat ◽  
Mk 801 ◽  
Aspartate Receptor ◽  
Serum Lh ◽  
Lh Secretion

ABSTRACT The physiological role of activated hypothalamic N-methyl-d-aspartate (NMDA) receptors during the final phase of female sexual maturation was explored in the rat. The effects of administration of the specific non-competitive receptor antagonist MK-801 on the occurrence of first ovulation and on LH secretion were studied. Injections of MK-801 (0·1–0·2 mg/kg body wt, s.c.) were given once or twice daily, starting at 28 or 35 days of age and continuing up to the day of first ovulation, resulted in a significant delay of this ovulation. Rats that were treated daily with 0·2 mg MK-801/kg, starting on days 30 or 34 and continuing up to day 38, but not including the day of first pro-oestrus, also showed retarded first ovulation. No decrease in serum LH concentration, compared with control rats, could be detected in these rats. Acute treatment with MK-801 (one or two injections of 0·2, or one injection of 0·5 mg/kg) given at 11.30 h (and 16.00 h) on the day of first pro-oestrus produced partial (1 × 0·2 mg/kg) or complete (2×0·2 and 1 × 0·5 mg/kg) blockade of first ovulation; blocked rats ovulated 1 day later. Serum LH concentrations at 16.00 h on the day of pro-oestrus were significantly decreased in all MK-801-treated groups compared with saline-injected control rats. At 19.00 and 22.00 h LH concentrations remained low in all non-ovulating MK-801-treated rats, but increased in the MK-801-treated rats that ovulated. Thus chronic blockade of the NMDA receptors by the antagonist MK-801 delays but does not prevent first ovulation, whereas acute treatment blocks the pro-oestrous LH peak. It was concluded that activation of NMDA receptors plays an important role both in tonic and preovulatory LH secretion during the onset of puberty in the female rat. Journal of Endocrinology (1991) 131, 435–441

Digastric muscle activities in anoxic infant rats

2004 ◽  
Vol 82 (11) ◽  
pp. 960-968 ◽  
Author(s):  
Chikako Saiki ◽  
Shigeji Matsumoto
Keyword(s):  
Receptor Antagonist ◽  
Trigeminal Nerve ◽  
Muscle Activity ◽  
Phase 1 ◽  
Digastric Muscle ◽  
Phase 2 ◽  
Mk 801 ◽  
Aspartate Receptor ◽  
Infant Rats ◽  
Developmental Age

The digastric muscle acts for both feeding (including mastication and swallowing) and respiration. In this study, we examined whether or not the muscle activity is detectable during anoxia in developing rats. Rats at 4 different ages, days 5, 10, 16, and 24, were exposed to 100% N2 under pentobarbital or ketamine–xylazine anesthesia, and the electromyograms of digastric muscles (dEMG) and the diaphragm (diaEMG) were examined simultaneously. Prior to the anoxic exposure, at all ages, the dEMG was similar to or less apparent than the diaEMG, which was detected at each inspiratory movement. In anoxia, we first observed dEMG activity, mostly sporadic (days 5 and 10) or mostly tonic (days 16 and 24), when diaEMG activity was temporarily suppressed (we termed it Phase 1). Second, synchronous phasic or tonic dEMG and phasic diaEMG were recorded temporarily before terminal apnea (we termed it Phase 2). These phenomena were also obtained in vagotomized rats (all ages) or in rats injected with the N-methyl-D-aspartate receptor antagonist MK-801 (dizocilpine (5R,10S)-(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate) (days 16 and 24). In conclusion, our results suggest that in anoxia, dEMG activity is detectable during diaEMG suppression in early anoxia, irrespective of the developmental age, the anesthetic (pentobarbital or ketamine–xylazine), vagotomy, or MK-801 injections.Key words: newborn, hypoxia, apnea, swallowing, trigeminal nerve.

Chronic treatment with caffeine blunts the hyperlocomotor but not cognitive effects of the N-methyl-d-aspartate receptor antagonist MK-801 in mice

2003 ◽  
Vol 166 (3) ◽  
pp. 258-263 ◽  
Author(s):  
Oscar P. Dall'Igna ◽  
Adriana L. da Silva ◽  
Marcelo O. Dietrich ◽  
Anselmo Hoffmann ◽  
Ricardo V. de Oliveira ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Chronic Treatment ◽  
Cognitive Effects ◽  
Mk 801 ◽  
Aspartate Receptor
Sign in / Sign up

Export Citation Format

Share Document