Metabolism, Distribution and Excretion of a Selective N-Methyl-d-Aspartate Receptor Antagonist, Traxoprodil, in Rats and Dogs

2007 ◽  
Vol 35 (8) ◽  
pp. 1350-1364 ◽  
Author(s):  
Chandra Prakash ◽  
Donghui Cui ◽  
Michael J. Potchoiba ◽  
Todd Butler
Keyword(s):  
Receptor Antagonist ◽  
Aspartate Receptor

scholarly journals Combination Therapy in Moderate to Severe Alzheimer’s Disease - Overview and Discussion Points for the Future

2011 ◽  
Vol 6 (4) ◽  
pp. 228
Author(s):  
José L Molinuevo ◽  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Combination Therapy ◽  
Receptor Antagonist ◽  
Cholinesterase Inhibitors ◽  
Current Data ◽  
Aspartate Receptor ◽  
The Future

Two effective symptomatic therapies are available for Alzheimer’s disease: the cholinesterase inhibitors (ChEIs) and memantine, an N-methyl-D-aspartate receptor antagonist. Current data demonstrate that combination therapy with memantine and a ChEI produces symptomatic benefits in all domains of AD. The benefits of combination therapy are greater than those of ChEI monotherapy, are sustained long term and appear to increase with time.

EFFECT OF N-METHYL-D-ASPARTATE RECEPTOR ANTAGONIST ON RADIATION-INDUCED GUT INJURIES IN MICE

2017 ◽  
Author(s):  
Masatsugu Ohgami ◽  
Nobuhiko Takai ◽  
Masahiko Watanabe ◽  
Koichi Ando ◽  
Akiko Uzawa ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Aspartate Receptor ◽  
Radiation Induced

Action of the N-Methyl-D-Aspartate Receptor Antagonist MK-801 against Focal Seizure Activity from the Feline Hippocampus

1992 ◽  
Vol 26 (4) ◽  
pp. 205-209 ◽  
Author(s):  
Yuji Wada ◽  
Hidehiro Hasegawa ◽  
Mitsuhiko Nakamura ◽  
Nariyoshi Yamaguchi
Keyword(s):  
Receptor Antagonist ◽  
Seizure Activity ◽  
Focal Seizure ◽  
Mk 801 ◽  
Aspartate Receptor

scholarly journals Suppression of Spreading Depression of Leão in Neocortex by an N-Methyl-D-Aspartate Receptor Antagonist

1992 ◽  
Vol 19 (4) ◽  
pp. 487-491 ◽  
Author(s):  
Richard S. McLachlan
Keyword(s):  
Receptor Antagonist ◽  
Spreading Depression ◽  
Excitatory Amino Acid ◽  
Mean Amplitude ◽  
Nmda Receptor Antagonist ◽  
Chemical Stimulation ◽  
Critical Element ◽  
Rate Of Spread ◽  
Interictal Spike ◽  
Aspartate Receptor

ABSTRACT:Spreading depression has been implicated in the pathophysiology of a number of diseases such as migraine, stroke and epilepsy. The characteristics of this phenomenon were explored in neocortex of anesthetized rats. Spreading depression was produced in 10 of 15 animals using mechanical, electrical and chemical stimulation. Mean amplitude of the DC shift was -9.3 mV, mean duration at any one electrode 65 sec and rate of spread 2-5 mm/min. Spreading depression was facilitated by focal interictal spike activity induced by penicillin and completely blocked by the N-methyl-D-aspartate (NMDA) receptor antagonist, DL-2-aminophosphonovaleric acid (APV), providing further evidence that excitatory amino acid neurotransmission is a critical element in the development or propagation of the phenomenon.

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