Saliva and plasma clearance of antipyrine as reflectors of liver function

1981 ◽  
Vol 6 (4) ◽  
pp. 261-264 ◽  
Author(s):  
P. V. Luoma ◽  
E. A. Sotaniemi
Keyword(s):  
Liver Function ◽  
Plasma Clearance

Experience with a standardized bromsulfalein plasma clearance method as a sensitive test of liver function

1953 ◽  
Vol 14 (4) ◽  
pp. 500-501
Author(s):  
J.W. Culbertson ◽  
T.L. Welton ◽  
K.H. Kinard ◽  
J.G. Easton
Keyword(s):  
Liver Function ◽  
Plasma Clearance ◽  
Sensitive Test

CLINICAL CHEMISTRY OF GRAIN-FED CATTLE. II. LIVER FUNCTION

1975 ◽  
Vol 55 (1) ◽  
pp. 23-29 ◽  
Author(s):  
R. W. BIDE ◽  
W. J. DORWARD
Keyword(s):  
Liver Function ◽  
Plasma Clearance ◽  
Clinical Chemistry ◽  
Feedlot Cattle ◽  
Feeding Period ◽  
Test Animal ◽  
Beet Pulp ◽  
Time Required ◽  
Vitamin Concentrate

The rate of plasma clearance of bilirubin (BCR), as a test of liver function, was followed in three hay-fed and four grain-fed Hereford steers over the first 77 days of a 106-day feeding period. The grain diet was 90% steam rolled barley, 5% beet pulp pellets and 5% of a protein/mineral/vitamin concentrate given together with a hay supplement of 0.9 kg/head/day. The grain was introduced slowly over a 10-day period. Fluctuations in hematocrit values occurred during the adaptation to the grain diet. Periodic episodes of markedly reduced liver function occurred synchronously in test animals during the introduction of the grain diet. Similar episodes of reduced liver function were observed with decreasing frequency and severity as the feeding progressed. After 25 days of grain feeding, loss of synchrony also occurred, so that high values were observed in only one test animal at any one time. As the feeding period progressed, the time required for the distribution and equilibration of the bilirubin in the blood increased in the grain-fed animals causing interference with the BCR tests. The effects on liver function indicated a reduction in the efficiency of the liver which probably contributes to pathologic conditions in feedlot cattle.

Effects of vinyl chloride on liver function of exposed workers, evaluated by measurements of plasma clearance of the99Tc–N-2,4-dimethylacetanilido-iminodiacetate complex

1989 ◽  
Vol 9 (4) ◽  
pp. 213-218 ◽  
Author(s):  
Michał Studniarek ◽  
Krzysztof Durski ◽  
Julian Liniecki ◽  
Dariusz Brykalski ◽  
Anna Poznańska ◽  
...  
Keyword(s):  
Liver Function ◽  
Vinyl Chloride ◽  
Plasma Clearance ◽  
Exposed Workers

Lupinosis of ewes around the time of mating reduces reproductive performance

1996 ◽  
Vol 47 (8) ◽  
pp. 1305 ◽  
Author(s):  
AL Barnes ◽  
KP Croker ◽  
JG Allen ◽  
ND Costa
Keyword(s):  
Plasma Concentration ◽  
Liver Function ◽  
Liver Damage ◽  
Reproductive Performance ◽  
Plasma Clearance ◽  
Gamma Glutamyl Transferase ◽  
Subcutaneous Injections ◽  
Combined Control ◽  
Glutamyl Transferase ◽  
And Control

Lupinosis was induced in Merino ewes by subcutaneous injections of phomopsin toxins, given for 2 weeks before and up to 2 weeks after the start of joining, and the reproductive performance of the injected ewes was compared with untreated control ewes. Two experiments were conducted in consecutive years, with similar results. The liver damage and impairment of liver function due to lupinosis were measured by increases in plasma activities of glutamate dehydrogenase and gamma glutamyl transferase, plasma concentration of bilirubin, and plasma clearance of bromosulfthalein. Ovulation rate was depressed by phomopsin administration (1.11 v. 1.33 for the combined phomopsin-treated and control ewes, P < 0.001), and fewer phomopsin-treated ewes were pregnant (70.4% for the combined phomopsin-treated ewes v. 93.8% for the combined control ewes, P < 0.01). Thus, fewer lambs were born to the phomopsin-treated ewes compared with the control ewes (66.0 v. 109.3% for the combined years, P < 0.01). These results indicate that there may be severe detrimental effects of phomopsin intoxication on reproductive performance of ewes.

Acetaminophen: Macula densa hypersecretory activity by induced hepatotoxicity

1987 ◽  
Vol 45 ◽  
pp. 934-935
Author(s):  
S.S. Poolsawat ◽  
C.A. Huerta ◽  
S.TY. Lae ◽  
G.A. Miranda
Keyword(s):  
Cell Proliferation ◽  
Liver Function ◽  
Chronic Inflammation ◽  
Foam Cell ◽  
Term Effect ◽  
Short Term ◽  
Drug Induced ◽  
Experimental Induction ◽  
Tissue Alterations ◽  
Toxic Responses

Introduction. Experimental induction of altered histology by chemical toxins is of particular importance if its outcome resembles histopathological phenomena. Hepatotoxic drugs and chemicals are agents that can be converted by the liver into various metabolites which consequently evoke toxic responses. Very often, these drugs are intentionally administered to resolve an illness unrelated to liver function. Because of hepatic detoxification, the resulting metabolites are suggested to be integrated into the macromolecular processes of liver function and cause an array of cellular and tissue alterations, such as increased cytoplasmic lysis, centrilobular and localized necroses, chronic inflammation and “foam cell” proliferation of the hepatic sinusoids (1-4).Most experimentally drug-induced toxicity studies have concentrated primarily on the hepatic response, frequently overlooking other physiological phenomena which are directly related to liver function. Categorically, many studies have been short-term effect investigations which seldom have followed up the complications to other tissues and organs when the liver has failed to function normally.

Oral Glucose Tolerance as a Test of Liver Function

1953 ◽  
Vol 25 (4) ◽  
pp. 548-552 ◽  
Author(s):  
Thomas J. Rankin ◽  
Robert L. Jenson ◽  
Mahlon Delp
Keyword(s):  
Liver Function ◽  
Glucose Tolerance ◽  
Oral Glucose ◽  
Oral Glucose Tolerance
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