99mTc-galactosyl-human Liver function evaluation by serum albumin scintigraphy. The contrast with antipyrine plasma clearance.

Kanzo ◽  
1996 ◽  
Vol 37 (2) ◽  
pp. 115-116
Author(s):  
KATSUYASU KODA
Keyword(s):  
Liver Function ◽  
Serum Albumin ◽  
Human Liver ◽  
Plasma Clearance ◽  
Function Evaluation

scholarly journals A clinical study on nimesulide hepatotoxicity

2018 ◽  
Vol 6 (11) ◽  
pp. 3523
Author(s):  
Manju K. Nair ◽  
Rema M. N. ◽  
Shenoy K. T.
Keyword(s):  
Liver Function ◽  
Adverse Effects ◽  
Serum Albumin ◽  
Tertiary Care ◽  
Liver Function Tests ◽  
Tertiary Care Centre ◽  
Function Tests ◽  
Serum Aspartate Aminotransferase ◽  
History Of Use ◽  
Blood Routine

Background: Hepatic injury can occur with the use of nimesulide, a non steroidal anti-inflammatory drug. This study was done to evaluate the hepatic and renal functions in patients with rheumatological complaints receiving nimesulide for 2 weeks.Methods: Fifty patients with rheumatological complaints treated at orthopaedic outpatient clinic of a tertiary care centre with nimesulide 100mg twice daily were enrolled in this study. The sociodemographic details, details of comorbidities, history of use of alcohol or tobacco, indication for treatment with nimesulide etc. were recorded in a predesigned proforma. All patients were followed up for two weeks and reviewed at the end of each week for any gastrointestinal adverse effects, changes in blood routine, liver function tests and renal function tests. Data collected was entered in Microsoft Excel 2010, analysed and results were expressed as mean and standard deviation.Results: Out of the fifty patients analysed, mean age was 39 years. 66 % were males. Among liver function tests, only serum albumin and serum aspartate aminotransferase (SGPT) were altered after treatment with nimesulide. Blood urea nitrogen, serum creatinine and blood routine remained normal. No gastrointestinal adverse effects were noted.Conclusions: Nimesulide produced changes in serum albumin and SGPT levels without prominent gastrointestinal or renal adverse effects.

scholarly journals Genome-wide transcriptome analysis identifies novel gene signatures implicated in human chronic liver disease

2013 ◽  
Vol 305 (5) ◽  
pp. G364-G374 ◽  
Author(s):  
Rana L. Smalling ◽  
Don A. Delker ◽  
Yuxia Zhang ◽  
Natalia Nieto ◽  
Michael S. Mcguiness ◽  
...  
Keyword(s):  
Liver Disease ◽  
Hepatitis C ◽  
Liver Function ◽  
Chronic Liver Disease ◽  
Nuclear Receptor ◽  
Liver Diseases ◽  
Human Liver ◽  
Chronic Liver ◽  
Rna Seq ◽  
Gene Signatures

The molecular mechanisms behind human liver disease progression to cirrhosis remain elusive. Nuclear receptor small heterodimer partner (SHP/ Nr0b2) is a hepatic tumor suppressor and a critical regulator of liver function. SHP expression is diminished in human cirrhotic livers, suggesting a regulatory role in human liver diseases. The goal of this study was to identify novel SHP-regulated genes that are involved in the development and progression of chronic liver disease. To achieve this, we conducted the first comprehensive RNA sequencing (RNA-seq) analysis of Shp−/− mice, compared the results with human hepatitis C cirrhosis RNA-seq and nonalcoholic steatohepatitis (NASH) microarray datasets, and verified novel results in human liver biospecimens. This approach revealed new gene signatures associated with chronic liver disease and regulated by SHP. Several genes were selected for validation of physiological relevance based on their marked upregulation, novelty with regard to liver function, and involvement in gene pathways related to liver disease. These genes include peptidoglycan recognition protein 2, dual specific phosphatase-4, tetraspanin 4, thrombospondin 1, and SPARC-related modular calcium binding protein-2, which were validated by qPCR analysis of 126 human liver specimens, including steatosis, fibrosis, and NASH, alcohol and hepatitis C cirrhosis, and in mouse models of liver inflammation and injury. This RNA-seq analysis identifies new genes that are regulated by the nuclear receptor SHP and implicated in the molecular pathogenesis of human chronic liver diseases. The results provide valuable transcriptome information for characterizing mechanisms of these diseases.

Use of Tc-99m DTPA Galactosyl Human Serum Albumin to Predict Postoperative Residual Liver Function

1999 ◽  
Vol 24 (6) ◽  
pp. 428-434 ◽  
Author(s):  
MASAKI UETAKE ◽  
KIYOSHI KOIZUMI ◽  
AKIHARU YAGAWA ◽  
HISASHI NOGATA ◽  
TORU TEZUKA ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Liver Function ◽  
Serum Albumin ◽  
Human Serum ◽  
Residual Liver Function ◽  
Galactosyl Human Serum Albumin ◽  
Postoperative Residual
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