Preparation of anthracene fine particles by rapid expansion of a supercritical solution process utilizing supercritical CO2

2004 ◽  
Vol 21 (6) ◽  
pp. 1245-1249 ◽  
Author(s):  
Hyun Kwak ◽  
Jin Woo Jung ◽  
Seong Youl Bae ◽  
Hidehiro Kumazawa
Keyword(s):  
Supercritical Co2 ◽  
Fine Particles ◽  
Solution Process ◽  
Rapid Expansion ◽  
Supercritical Solution

Continuous nanonization of lonidamine by modified-rapid expansion of supercritical solution process

2018 ◽  
Vol 133 ◽  
pp. 486-493 ◽  
Author(s):  
Biao-Qi Chen ◽  
Ranjith Kumar Kankala ◽  
Shi-Bin Wang ◽  
Ai-Zheng Chen
Keyword(s):  
Solution Process ◽  
Rapid Expansion ◽  
Supercritical Solution

Response Surface Optimization of Catechin Liposomes Preparation Using the Rapid Expansion of Supercritical Solution Process

2020 ◽  
Vol 20 (12) ◽  
pp. 7583-7592
Author(s):  
Zhen Jiao ◽  
Sai Han ◽  
Weifang Wang ◽  
Jiangrui Cheng ◽  
Junying Song
Keyword(s):  
Response Surface ◽  
Solution Process ◽  
Rapid Expansion ◽  
Mass Ratio ◽  
Box Behnken Design ◽  
Response Surface Optimization ◽  
Hydrophilic Drug ◽  
Single Factor Analysis ◽  
Supercritical Solution

Phospholipid liposomes are a promising drug delivery system. Catechin, a hydrophilic drug, was used to prepare catechin liposomes through a modified rapid expansion of supercritical solution (RESS) process in this study. The influences of operation parameters (i.e., temperature, pressure, and mass ratio of liposomal materials to catechin) on the properties of the prepared liposomes were determined using the single-factor analysis. The process was further optimized by response surface methodology (RSM) based on the Box-Behnken design (BBD). The encapsulation efficiency (EE) values can be adequately predicted using the obtained equation. The maximum EE value can reach 61.36±0.68% under the optimal parameters (i.e., the expansion temperature, pressure, and p/c mass ratio were 56.34 °C, 19.99 MPa, and 5.99, respectively). The prepared liposomes can effectively protect and stabilize the loaded catechin effectively. In addition, the in vitro release study showed the slow and sustained release behavior of the catechin liposomes.

Micronization of ketoprofen by the rapid expansion of supercritical solution process

2010 ◽  
Vol 41 (8) ◽  
pp. 821-833 ◽  
Author(s):  
Ali Zeinolabedini Hezave ◽  
Sarah Aftab ◽  
Feridun Esmaeilzadeh
Keyword(s):  
Solution Process ◽  
Rapid Expansion ◽  
Supercritical Solution

Nanoparticle Production of Zingiber officinale Roscoe Rhizome Extracts by ESS (expansion of supercritical solution)

2021 ◽  
Vol 11 ◽  
Author(s):  
Zahra Rezvanjoo ◽  
Farhad Raofie
Keyword(s):  
Supercritical Co2 ◽  
High Speed ◽  
Zingiber Officinale ◽  
Rapid Expansion ◽  
Needle Valve ◽  
Vast Number ◽  
Nanoparticle Production ◽  
Zingiber Officinale Roscoe ◽  
Supercritical Solution ◽  
Solution Methodology

Aims: To propose a modified RESS method of herbal pharmaceutical extracts nanoparticle production. Background: A vast number of methods have been applied to water-insoluble pharmaceuticals to improve their solubility. Nanoparticle production of pharmaceuticals is considered as one of the high-speed ways to improve solubility. Objective: Supercritical CO2 was applied to extract Zingiber officinale Roscoe rhizome pharmaceutical. Then a modified RESS (rapid expansion of supercritical solution) method, called ESS (expansion of supercritical solution), was exerted to obtain NPs (nanoparticles) of the extracted pharmaceuticals. Methods: Initially, applying high pressure in supercritical CO2 contributed to the extract dissolution such that supercritical CO2 was saturated with the sample. Then by decreasing the pressure, an expansion occurred in the saturated medium. This expansion reduced the power of supercritical CO2 solvent and induced the sample nanoparticle nucleation in the needle valve. Conclusion: Unlike rapid expansion of supercritical solution methodology, in this technique, the initial and secondary pressures were permanently above the critical pressure to provide a gentle expansion, which contributes to the production of uniform and small particles. The obtained uniform NPs had a narrow size distribution. Consequently, ESS technique can be considered as an efficient technique for improving the solubility of hydrophobic pharmaceuticals such as [6]-gingerol.

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