Impact of rapid expansion of supercritical solution process conditions on the crystallinity of poly(vinylidene fluoride) nanoparticles

2016 ◽  
Vol 117 ◽  
pp. 18-25 ◽  
Author(s):  
Simone Wolff ◽  
Sabine Beuermann ◽  
Michael Türk
Keyword(s):  
Vinylidene Fluoride ◽  
Solution Process ◽  
Rapid Expansion ◽  
Process Conditions ◽  
Poly Vinylidene Fluoride ◽  
Supercritical Solution ◽  
Fluoride Nanoparticles

scholarly journals Submicron Poly(vinylidene fluoride) Particles from Rapid Expansion of Supercritical Solution

2008 ◽  
Vol 80 (9) ◽  
pp. 1403-1404
Author(s):  
M. Türk ◽  
E. Breininger ◽  
S. Beuermann ◽  
M. Imran-ul-haq
Keyword(s):  
Vinylidene Fluoride ◽  
Rapid Expansion ◽  
Poly Vinylidene Fluoride ◽  
Supercritical Solution

Continuous nanonization of lonidamine by modified-rapid expansion of supercritical solution process

2018 ◽  
Vol 133 ◽  
pp. 486-493 ◽  
Author(s):  
Biao-Qi Chen ◽  
Ranjith Kumar Kankala ◽  
Shi-Bin Wang ◽  
Ai-Zheng Chen
Keyword(s):  
Solution Process ◽  
Rapid Expansion ◽  
Supercritical Solution

Colloidal Crystallization and Ionic Liquid Induced Partial β-Phase Transformation of Poly(vinylidene fluoride) Nanoparticles

2015 ◽  
Vol 48 (8) ◽  
pp. 2570-2575 ◽  
Author(s):  
Daichi Okada ◽  
Hideki Kaneko ◽  
Katsuhiro Kato ◽  
Seiichi Furumi ◽  
Masaki Takeguchi ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Phase Transformation ◽  
Vinylidene Fluoride ◽  
Β Phase ◽  
Colloidal Crystallization ◽  
Poly Vinylidene Fluoride ◽  
Fluoride Nanoparticles

Response Surface Optimization of Catechin Liposomes Preparation Using the Rapid Expansion of Supercritical Solution Process

2020 ◽  
Vol 20 (12) ◽  
pp. 7583-7592
Author(s):  
Zhen Jiao ◽  
Sai Han ◽  
Weifang Wang ◽  
Jiangrui Cheng ◽  
Junying Song
Keyword(s):  
Response Surface ◽  
Solution Process ◽  
Rapid Expansion ◽  
Mass Ratio ◽  
Box Behnken Design ◽  
Response Surface Optimization ◽  
Hydrophilic Drug ◽  
Single Factor Analysis ◽  
Supercritical Solution

Phospholipid liposomes are a promising drug delivery system. Catechin, a hydrophilic drug, was used to prepare catechin liposomes through a modified rapid expansion of supercritical solution (RESS) process in this study. The influences of operation parameters (i.e., temperature, pressure, and mass ratio of liposomal materials to catechin) on the properties of the prepared liposomes were determined using the single-factor analysis. The process was further optimized by response surface methodology (RSM) based on the Box-Behnken design (BBD). The encapsulation efficiency (EE) values can be adequately predicted using the obtained equation. The maximum EE value can reach 61.36±0.68% under the optimal parameters (i.e., the expansion temperature, pressure, and p/c mass ratio were 56.34 °C, 19.99 MPa, and 5.99, respectively). The prepared liposomes can effectively protect and stabilize the loaded catechin effectively. In addition, the in vitro release study showed the slow and sustained release behavior of the catechin liposomes.

scholarly journals Recrystallization and Micronization of p-Toluenesulfonamide Using the Rapid Expansion of Supercritical Solution (RESS) Process

Crystals ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. 449 ◽  
Author(s):  
Tsung-Mao Yang ◽  
Chie-Shaan Su ◽  
Jin-Shuh Li ◽  
Kai-Tai Lu ◽  
Tsao-Fa Yeh
Keyword(s):  
Operating Conditions ◽  
Rapid Expansion ◽  
Optimum Operating ◽  
Control Factor ◽  
Process Conditions ◽  
Extraction Temperature ◽  
Control Factors ◽  
Supercritical Solution ◽  
Average Size ◽  
Expansion Temperature

This study is focused on the micronization of p-toluenesulfonamide (p-TSA) using the rapid expansion of supercritical solution (RESS) process. Taguchi’s experimental design method was applied to determine the optimum operating conditions. L9(34) orthogonal array with four control factors and three levels of each control factor was used to design nine experimental conditions. Four control factors were selected, including extraction temperature, extraction pressure, pre-expansion temperature, and post-expansion temperature. The particle size and morphology of the prepared samples were observed by scanning electron microscopy (SEM). In addition, Fourier transform infrared spectrometer (FTIR), X-ray diffraction (XRD), and differential scanning calorimetry (DSC) were employed to compare the differences between the raw and micronized p-TSA particles. The experimental and analytical results indicated that the extraction temperature was the most significant factor for the micronization of p-TSA in the RESS process, and the optimal operating conditions were at an extraction temperature of 50 °C, an extraction pressure of 220 MPa, a pre-expansion temperature of 220 °C, and a post-expansion temperature of 30 °C. The p-TSA particles were micronized from the original average size of 294.8 μm to the smallest average size of 1.1 μm at the optimal RESS process conditions. Furthermore, the physicochemical characteristics of p-TSA did not differ significantly before and after recrystallization.

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