Numerical simulation of particle formation in the rapid expansion of supercritical solution process

2014 ◽  
Vol 95 ◽  
pp. 572-587 ◽  
Author(s):  
Jiewei Liu ◽  
Gustav Amberg ◽  
Minh Do-Quang
Keyword(s):  
Numerical Simulation ◽  
Solution Process ◽  
Particle Formation ◽  
Rapid Expansion ◽  
Supercritical Solution

Continuous nanonization of lonidamine by modified-rapid expansion of supercritical solution process

2018 ◽  
Vol 133 ◽  
pp. 486-493 ◽  
Author(s):  
Biao-Qi Chen ◽  
Ranjith Kumar Kankala ◽  
Shi-Bin Wang ◽  
Ai-Zheng Chen
Keyword(s):  
Solution Process ◽  
Rapid Expansion ◽  
Supercritical Solution

Response Surface Optimization of Catechin Liposomes Preparation Using the Rapid Expansion of Supercritical Solution Process

2020 ◽  
Vol 20 (12) ◽  
pp. 7583-7592
Author(s):  
Zhen Jiao ◽  
Sai Han ◽  
Weifang Wang ◽  
Jiangrui Cheng ◽  
Junying Song
Keyword(s):  
Response Surface ◽  
Solution Process ◽  
Rapid Expansion ◽  
Mass Ratio ◽  
Box Behnken Design ◽  
Response Surface Optimization ◽  
Hydrophilic Drug ◽  
Single Factor Analysis ◽  
Supercritical Solution

Phospholipid liposomes are a promising drug delivery system. Catechin, a hydrophilic drug, was used to prepare catechin liposomes through a modified rapid expansion of supercritical solution (RESS) process in this study. The influences of operation parameters (i.e., temperature, pressure, and mass ratio of liposomal materials to catechin) on the properties of the prepared liposomes were determined using the single-factor analysis. The process was further optimized by response surface methodology (RSM) based on the Box-Behnken design (BBD). The encapsulation efficiency (EE) values can be adequately predicted using the obtained equation. The maximum EE value can reach 61.36±0.68% under the optimal parameters (i.e., the expansion temperature, pressure, and p/c mass ratio were 56.34 °C, 19.99 MPa, and 5.99, respectively). The prepared liposomes can effectively protect and stabilize the loaded catechin effectively. In addition, the in vitro release study showed the slow and sustained release behavior of the catechin liposomes.

Micronization of ketoprofen by the rapid expansion of supercritical solution process

2010 ◽  
Vol 41 (8) ◽  
pp. 821-833 ◽  
Author(s):  
Ali Zeinolabedini Hezave ◽  
Sarah Aftab ◽  
Feridun Esmaeilzadeh
Keyword(s):  
Solution Process ◽  
Rapid Expansion ◽  
Supercritical Solution
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