Pathogenesis of oleic acid-induced lung injury in the rat: Distribution of oleic acid during injury and early endothelial cell changes

Lipids ◽  
1995 ◽  
Vol 30 (9) ◽  
pp. 817-823 ◽  
Author(s):  
Greg Beilman
Keyword(s):  
Oleic Acid ◽  
Endothelial Cell ◽  
Lung Injury ◽  
Cell Changes

Effects of Vaporized Perfluorocarbon on Pulmonary Blood Flow and Ventilation/Perfusion Distribution in a Model of Acute Respiratory Distress Syndrome

2001 ◽  
Vol 95 (6) ◽  
pp. 1414-1421 ◽  
Author(s):  
Matthias Hübler ◽  
Jennifer E. Souders ◽  
Erin D. Shade ◽  
Nayak L. Polissar ◽  
Carmel Schimmel ◽  
...  
Keyword(s):  
Blood Flow ◽  
Oleic Acid ◽  
Gas Exchange ◽  
Lung Injury ◽  
Repeated Measures ◽  
Pulmonary Blood Flow ◽  
Analysis Of Covariance ◽  
Inert Gas ◽  
Low Flow ◽  
Repeated Measures Analysis

Background Perfluorocarbon (PFC) liquids are known to improve gas exchange and pulmonary function in various models of acute respiratory failure. Vaporization has been recently reported as a new method of delivering PFC to the lung. Our aim was to study the effect of PFC vapor on the ventilation/perfusion (VA/Q) matching and relative pulmonary blood flow (Qrel) distribution. Methods In nine sheep, lung injury was induced using oleic acid. Four sheep were treated with vaporized perfluorohexane (PFX) for 30 min, whereas the remaining sheep served as control animals. Vaporization was achieved using a modified isoflurane vaporizer. The animals were studied for 90 min after vaporization. VA/Q distributions were estimated using the multiple inert gas elimination technique. Change in Qrel distribution was assessed using fluorescent-labeled microspheres. Results Treatment with PFX vapor improved oxygenation significantly and led to significantly lower shunt values (P < 0.05, repeated-measures analysis of covariance). Analysis of the multiple inert gas elimination technique data showed that animals treated with PFX vapor demonstrated a higher VA/Q heterogeneity than the control animals (P < 0.05, repeated-measures analysis of covariance). Microsphere data showed a redistribution of Qrel attributable to oleic acid injury. Qrel shifted from areas that were initially high-flow to areas that were initially low-flow, with no difference in redistribution between the groups. After established injury, Qrel was redistributed to the nondependent lung areas in control animals, whereas Qrel distribution did not change in treatment animals. Conclusion In oleic acid lung injury, treatment with PFX vapor improves gas exchange by increasing VA/Q heterogeneity in the whole lung without a significant change in gravitational gradient.

Corneal Endothelial Cell Changes After Femtosecond Laser–Assisted Cataract Surgery in Diabetic and Nondiabetic Patients

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Kyoung Hae Kang ◽  
Mi Yeon Song ◽  
Kook Young Kim ◽  
Kyu Yeon Hwang ◽  
Young A Kwon ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Femtosecond Laser ◽  
Cataract Surgery ◽  
Corneal Endothelial Cell ◽  
Cell Changes

Endothelial Cell Changes in Endotoxin-lnduced Uveitis

1994 ◽  
Vol 26 (1) ◽  
pp. 8-16 ◽  
Author(s):  
J.L. Alió ◽  
Ch. García-Elskamp ◽  
Ruiz Moreno ◽  
Ruiz Moreno
Keyword(s):  
Endothelial Cell ◽  
Cell Changes

scholarly journals Intratracheal Pulmonary Ventilation vs. Conventional Ventilation in an Oleic Acid Lung Injury Model in the Young Lamb 197

1998 ◽  
Vol 43 ◽  
pp. 36-36
Author(s):  
Allyson M Goodman ◽  
L Kyle Walker ◽  
Oswaldo Rivera ◽  
Winslow R Seale ◽  
Billie L Short
Keyword(s):  
Oleic Acid ◽  
Lung Injury ◽  
Pulmonary Ventilation ◽  
Conventional Ventilation ◽  
Injury Model ◽  
Lung Injury Model
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