Content of testosterone and activity of 5α-steroid-NAD(P)Δ4-oxidoreductase in normal bone tissue and malignant bone tumors

1997 ◽  
Vol 124 (3) ◽  
pp. 891-893
Author(s):  
P. V. Sergeev ◽  
S. A. Chukaev ◽  
E. V. Gorbatenko ◽  
N. E. Kushlinskii
Keyword(s):  
Bone Tissue ◽  
Bone Tumors ◽  
Malignant Bone Tumors ◽  
Normal Bone ◽  
Normal Bone Tissue

scholarly journals Osseous Choristoma of the Tongue: A Review of Etiopathogenesis

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Edoardo Gorini ◽  
Mauro Mullace ◽  
Luca Migliorini ◽  
Emilio Mevio
Keyword(s):  
Bone Tissue ◽  
Surgical Excision ◽  
Definitive Diagnosis ◽  
Histopathologic Examination ◽  
Review Of The Literature ◽  
Oral Region ◽  
Normal Bone ◽  
Normal Bone Tissue

Osseous choristoma is a normal bone tissue in an ectopic position. In the oral region lingual localization occurs more frequently and the mass is generally localized on the dorsum of the tongue. Definitive diagnosis is obtained only after histopathologic examination. The etiology remains already debatable. The treatment of choice is surgical excision. In this paper we present a case of tongue osseous choristoma and a review of the literature.

Scintigraphy with 99m Tc-Phosphonate and 67Gallium in Patients Suspected of Primary Bone Tumors

1982 ◽  
Vol 21 (04) ◽  
pp. 136-139 ◽  
Author(s):  
C.-J. Edeling
Keyword(s):  
Soft Tissue ◽  
Bone Scintigraphy ◽  
Primary Tumor ◽  
Bone Tumors ◽  
Whole Body ◽  
Skeletal Metastases ◽  
Malignant Bone Tumors ◽  
67Ga Scintigraphy ◽  
Primary Bone Tumors ◽  
Primary Bone

Whole-body scintigraphy with both 99mTc-phosphonate and 67Ga was performed on 92 patients suspected of primary bone tumors. In 46 patients with primary malignant bone tumors, scintigraphy with 99mTc-phosphonate disclosed the primary tumor in 44 cases and skeletal metastases in 11, and 67Ga scintigraphy detected the primary tumor in 43 cases, skeletal metastases in 6 cases and soft-tissue metastases in 8 cases. In 25 patients with secondary malignant bone tumors, bone scintigraphy visualized a single lesion in 10 cases and several lesions in 15 cases, and 67Ga scintigraphy detected the primary tumor in 17 cases, skeletal metastases in 17 cases and soft-tissue metastases in 9 cases. In 21 patients with benign bone disease positive uptake of 99mTc-phosphonate was recognized in 19 cases and uptake of 67Ga in 17 cases. It is concluded that bone scintigraphy should be used in patients suspected of primary bone tumors. If malignancy is suspected, 67Ga scintigraphy should be performed in addition.

MR-Derived CT-Like Images and Simulated Radiographs versus Conventional Radiography in Patients with Benign and Malignant Bone Tumors

2018 ◽  
Author(s):  
Alexandra Gersing ◽  
Daniela Muenzel ◽  
Felix Kopp ◽  
Benedikt Schwaiger ◽  
Carolin Knebel ◽  
...  
Keyword(s):  
Bone Tumors ◽  
Conventional Radiography ◽  
Malignant Bone Tumors

scholarly journals Genes associated with inflammation and bone remodeling are highly expressed in the bone of patients with the early-stage cam-type femoroacetabular impingement

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Guanying Gao ◽  
Ruiqi Wu ◽  
Rongge Liu ◽  
Jianquan Wang ◽  
Yingfang Ao ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bone Tissue ◽  
Bone Remodeling ◽  
Femoroacetabular Impingement ◽  
Early Stage ◽  
Control Group ◽  
Tissue Samples ◽  
Expression Levels ◽  
Normal Bone ◽  
Impingement Zone

Abstract Background Recent studies have shown high expression levels of certain inflammatory, anabolic, and catabolic genes in the articular cartilage from the impingement zone of the hips with femoroacetabular impingement (FAI), representing an increased metabolic state. Nevertheless, little is known about the molecular properties of bone tissue from the impingement zone of hips with FAI. Methods Bone tissue samples from patients with early-stage cam-type FAI were collected during hip arthroscopy for treatment of cam-type FAI. Control bone tissue samples were collected from six patients who underwent total hip replacement because of a femoral neck fracture. Quantitative real-time polymerase chain reaction (PCR) was performed to determine the gene expression associated with inflammation and bone remodeling. The differences in the gene expression in bone tissues from the patients with early-stage cam-type FAI were also evaluated based on clinical parameters. Results In all, 12 patients with early-stage cam-type FAI and six patients in the control group were included in this study. Compared to the control samples, the bone tissue samples from patients with FAI showed higher expression levels of interleukin-6 (IL-6), alkaline phosphatase (ALP), receptor activator of nuclear factor-kB ligand (RANKL), and osteoprotegerin (OPG) (P < 0.05). IL-1 expression was detected only in the control group. On the other hand, there was no significant difference in IL-8 expression between the patients with FAI and the control group. The patients with FAI having a body mass index (BMI) of >24 kg/m2 showed higher ALP expression (P < 0.05). Further, the expression of IL-6 and ALP was higher in the patients with FAI in whom the lateral center-edge angle was >30° (P < 0.05). Conclusions Our results indicated the metabolic condition of bone tissues in patients with early-stage cam-type FAI differed from that of normal bone in the femoral head-neck junction. The expression levels of the genes associated with inflammation and bone remodeling were higher in the bone tissue of patients with early-stage cam-type FAI than in the patients with normal bone tissue.

scholarly journals Malignant bone tumors in Kuwait

2005 ◽  
Vol 29 (6) ◽  
pp. 406-411 ◽  
Author(s):  
K. C. Katchy ◽  
F. Ziad ◽  
S. Alexander ◽  
H. Gad ◽  
M. Abdel Mota'al
Keyword(s):  
Bone Tumors ◽  
Malignant Bone Tumors

scholarly journals Experience with extendable prostheses for malignant bone tumors in children

2011 ◽  
Vol 110 (11) ◽  
pp. 711-715 ◽  
Author(s):  
Yukihiro Yoshida ◽  
Shunzo Osaka ◽  
Yasuaki Tokuhashi
Keyword(s):  
Bone Tumors ◽  
Malignant Bone Tumors

Effect of Bone Tumor and Osteoporosis on Mechanical Properties of Bone and Bone Tissue Properties: A Finite Element Study

2007 ◽  
Author(s):  
Vipul P. Gohil ◽  
Paul K. Canavan ◽  
Hamid Nayeb-Hashemi
Keyword(s):  
Mechanical Properties ◽  
Finite Element ◽  
Bone Density ◽  
Bone Tissue ◽  
Bone Tumor ◽  
Cellular Structure ◽  
Bone Tumors ◽  
World Health ◽  
Tissue Stiffness ◽  
Tissue Properties

This research is aimed to study the variations in the biomechanical behavior of bone and bone tissues with osteoporosis and bone tumors. Osteoporosis and bone tumors reduce the mechanical strength of bone, which creates a greater risk of fracture. In the United States alone, ten million individuals, eight million of whom are women, are estimated to already have osteoporosis, and almost 34 million more are estimated to have low bone mass (osteopenia) placing them at increased risk for osteoporosis. World Health Organization defines osteopenia, as a bone density between one and two and a half standard deviations (SD) below the bone density of a normal young adult. (Osteoporosis is defined as 2.5 SD or more below that reference point.). Together, osteoporosis and osteopenia are expected to affect an estimated 52 million women and men age 50 and older by 2010, and 61 million by 2020. The current medical cost of osteoporosis total is nearly about $18 billion in the U.S. each year. There is a dearth of literature that addresses the effects of osteoporosis on bone tissue properties. Furthermore, there are few studies published related to the effect of bone tumors such as Adamantinoma of long bones, Aneurysmal bone cyst, Hemangioma and others on overall behavior of bone. To understand the variations in bio-mechanical properties of internal tissues of bone with osteoporosis and bone tumor, a 2D finite element (FE) model of bone is developed using ANSYS 9.0 ® (ANSYS Inc., Canonsburg, PA). Trabecular bone is modeled using hexagonal and voronoi cellular structure. This finite element model is subjected to change in BVF (bone volume fraction) and bone architecture caused by osteoporosis. The bone tumor is modeled as finer multi-cellular structure and the effects of its size, location, and property variation of tumor on overall bone behavior are studied. Results from this analysis and comparative data are used to determine behavior of bone and its tissue over different stage of osteoporosis and bone tumor. Results indicate that both bone tumor and osteoporosis significantly change the mechanical properties of the bone. The results show that osteoporosis increases the bone tissue stiffness significantly as BVF reduces. Bone tissue stiffness is found to increase by 80 percent with nearly 55 percent reduction of BVF. The results and methods developed in this research can be implemented to monitor variation in bio-mechanical properties of bone up to tissue level during medication or to determine type and time for need of external support such as bracing.

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