Reaction of C-reactive protein with interleukin-2 receptor α-Chain

1998 ◽  
Vol 125 (6) ◽  
pp. 582-584 ◽  
Author(s):  
P. G. Nazarov
Keyword(s):  
Interleukin 2 ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Interleukin 2 Receptor ◽  
Α Chain

Association of Soluble Interleukin-2 Receptor and C-Reactive Protein with the Efficacy of Bendamustine Salvage Treatment for Indolent Lymphomas and Mantle Cell Lymphoma

2018 ◽  
Vol 139 (1) ◽  
pp. 12-18 ◽  
Author(s):  
Yukiko Kawaguchi ◽  
Tsuyoshi Nakamaki ◽  
Maasa Abe ◽  
Yuta Baba ◽  
So Murai ◽  
...  
Keyword(s):  
Mantle Cell Lymphoma ◽  
Cell Lymphoma ◽  
Interleukin 2 ◽  
Complete Response ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Interleukin 2 Receptor ◽  
Mantle Cell ◽  
Soluble Interleukin 2 Receptor ◽  
Indolent Lymphomas

Bendamustine has demonstrated favourable efficacy in relapsed or refractory indolent lymphoma and mantle cell lymphoma. We retrospectively evaluated the pre-treatment clinical and laboratory factors and their correlation with the clinical outcome of these lymphomas. We analysed 53 patients who had been treated with bendamustine alone (n = 6) or rituximab plus bendamustine (n = 47). The overall response rate was 81.1%, with a complete response (CR) rate of 39.6%. The CR rate was significantly low in patients who had elevated levels of soluble interleukin-2 receptor (p = 0.024) and C-reactive protein (CRP; p = 0.004). The 1-year overall survival (OS) rate was 79.3%. An elevated CRP was associated with a short OS (p = 0.056). The present findings suggest that the lymphoma microenvironment and immune response were involved in the effects of bendamustine. These findings are also important in order to understand the pathophysiology of refractory lymphoma and to find effective strategies using bendamustine.

Mutation of Asp20of human interleukin-2 reveals a dual role of the p55 α chain of the interleukin-2 receptor

1993 ◽  
Vol 23 (4) ◽  
pp. 917-921 ◽  
Author(s):  
Claudia L. Flemming ◽  
Stephen J. Russell ◽  
Mary K. L. Collins
Keyword(s):  
Interleukin 2 ◽  
Dual Role ◽  
Interleukin 2 Receptor ◽  
Α Chain

Peptide nucleic acids directed to the promoter of the α-chain of the interleukin-2 receptor

1996 ◽  
Vol 1309 (3) ◽  
pp. 226-238 ◽  
Author(s):  
Danièle Praseuth ◽  
Mikhaïl Grigoriev ◽  
Anne-Laure Guieysse ◽  
Linda Louise Pritchard ◽  
Annick Harel-Bellan ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Peptide Nucleic Acids ◽  
Interleukin 2 ◽  
Interleukin 2 Receptor ◽  
Α Chain

Expression of Soluble Human Interleukin-2 Receptor α-Chain inEscherichia coli

1995 ◽  
Vol 6 (6) ◽  
pp. 737-747 ◽  
Author(s):  
Stella Dracheva ◽  
Robert E. Palermo ◽  
Gordon D. Powers ◽  
David S. Waugh
Keyword(s):  
Interleukin 2 ◽  
Inescherichia Coli ◽  
Interleukin 2 Receptor ◽  
Α Chain

Interleukin 2 receptor α chain gene polymorphisms and risks of multiple sclerosis and neuromyelitis optica in southern Japanese

2014 ◽  
Vol 337 (1-2) ◽  
pp. 147-150 ◽  
Author(s):  
Gulibahaer Ainiding ◽  
Yuji Kawano ◽  
Shinya Sato ◽  
Noriko Isobe ◽  
Takuya Matsushita ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Neuromyelitis Optica ◽  
Gene Polymorphisms ◽  
Interleukin 2 ◽  
Chain Gene ◽  
Interleukin 2 Receptor ◽  
Α Chain
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