Differential effects of intra-accumbens and systemic amphetamine on latent inhibition using an on-baseline, within-subject conditioned suppression paradigm

1993 ◽  
Vol 110 (4) ◽  
pp. 479-489 ◽  
Author(s):  
A. S. Killcross ◽  
T. W. Robbins
Keyword(s):  
Latent Inhibition ◽  
Conditioned Suppression ◽  
Differential Effects

Dorsal bundle lesions do not affect latent inhibition of conditioned suppression

1984 ◽  
Vol 84 (4) ◽  
pp. 549-555 ◽  
Author(s):  
E. Tsaltas ◽  
G. C. Preston ◽  
J. N. P. Rawlins ◽  
G. Winocur ◽  
J. A. Gray
Keyword(s):  
Latent Inhibition ◽  
Conditioned Suppression ◽  
Dorsal Bundle

The effects of ritanserin, RU 24969 and 8-OH-DPAT on latent inhibition in the rat

1993 ◽  
Vol 7 (1_suppl) ◽  
pp. 63-71 ◽  
Author(s):  
Helen J. Cassaday ◽  
Helen Hodges ◽  
Jeffrey A. Gray
Keyword(s):  
Latent Inhibition ◽  
Conditioned Suppression ◽  
Opposite Effect ◽  
Partial Support ◽  
Attentional Deficits ◽  
Acute Schizophrenia ◽  
Retarding Effect ◽  
Ru 24969 ◽  
Serotonergic Function

When animals are exposed to a stimulus that has no consequences they are subsequently impaired in learning that this stimulus predicts an important event, such as footshock. This retarding effect of stimulus pre-exposure is called latent inhibition (LI) and is reliably disrupted by amphetamine, antipsychotics having an opposite effect. The present experiments investigated whether agents which affect serotonergic transmission also attenuate LI, using a conditioned suppression of drinking procedure. The results showed that the 5-HT2 antagonist ritanserin (2.0 mg/kg), and the 5-HT1b agonist RU 24969 (0.5 and 10.0 mg/kg) attenuated LI by increasing learning in pre-exposed animals, whilst the effects of the 5-HT1a agonist 8-OH-DPAT (0.38 mg/kg), though in a similar direction, were not significant. These experiments provide partial support for the involvement of serotonin in LI. Since amphetamine-induced attenuation of LI has been proposed as a model for the attentional deficits found in acute schizophrenia, these results are discussed in terms of the possible involvement of reduced serotonergic function in schizophrenic attentional disorder.

Differential effects of lesions in medial and dorsal raphe of the rat: Latent inhibition and septohippocampal serotonin levels.

1980 ◽  
Vol 94 (1) ◽  
pp. 145-154 ◽  
Author(s):  
Paul R. Solomon ◽  
Gwen L. Nichols ◽  
Joseph M. Kiernan ◽  
Russell S. Kamer ◽  
Lawrence J. Kaplan
Keyword(s):  
Latent Inhibition ◽  
Dorsal Raphe ◽  
Differential Effects ◽  
Dorsal Raphé

Associative learning and latent inhibition in a conditioned suppression paradigm in humans

2000 ◽  
Vol 117 (1-2) ◽  
pp. 53-60 ◽  
Author(s):  
João Vinicius Salgado ◽  
Marc Vidal ◽  
Philippe Oberling ◽  
Frederico Guilherme Graeff ◽  
Jean Marie Danion ◽  
...  
Keyword(s):  
Associative Learning ◽  
Latent Inhibition ◽  
Conditioned Suppression

scholarly journals EMD386088 (5 mg/kg) has no effect on latent inhibition shown to both light and noise stimuli

2019 ◽  
Vol 34 (1) ◽  
pp. 145-147
Author(s):  
Helen Joan Cassaday ◽  
Karen Elizabeth Thur
Keyword(s):  
Fear Conditioning ◽  
Latent Inhibition ◽  
Conditioned Suppression ◽  
Conditioning Procedure ◽  
Conditioned Stimuli ◽  
Receptor Antagonists ◽  
Clinical Model ◽  
Attentional Switching

Activation of 5-hydroxytyptamine6 (5-HT6) receptors stimulates attentional switching and 5-HT6 receptor antagonists are putative drugs for psychosis. Latent inhibition (LI) provides a pre-clinical model of attentional switching and ‘antipsychotic-like’ action and is known to be modulated by 5-hydroxytyptamine. In the present study, LI was shown in a fear conditioning procedure that measured suppression of drinking after conditioning with footshock. In two experiments (each n = 48) it was shown that pre-exposure to both light- and noise-conditioned stimuli reduced conditioned suppression relative to the corresponding non-pre-exposed control. However, counter to prediction, LI was intact after treatment with the 5-HT6 agonist EMD386088 (5 mg/kg).

The differential effects of chlorpromazine and haloperidol on latent inhibition in healthy volunteers

2001 ◽  
Vol 15 (2) ◽  
pp. 96-104 ◽  
Author(s):  
Denise McCartan ◽  
Robert Bell ◽  
Jonathan F. Green ◽  
Clarke Campbell ◽  
Karen Trimble ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Latent Inhibition ◽  
Differential Effects
Sign in / Sign up

Export Citation Format

Share Document