Dorsal bundle lesions do not affect latent inhibition of conditioned suppression

1984 ◽  
Vol 84 (4) ◽  
pp. 549-555 ◽  
Author(s):  
E. Tsaltas ◽  
G. C. Preston ◽  
J. N. P. Rawlins ◽  
G. Winocur ◽  
J. A. Gray
Keyword(s):  
Latent Inhibition ◽  
Conditioned Suppression ◽  
Dorsal Bundle

The effects of ritanserin, RU 24969 and 8-OH-DPAT on latent inhibition in the rat

1993 ◽  
Vol 7 (1_suppl) ◽  
pp. 63-71 ◽  
Author(s):  
Helen J. Cassaday ◽  
Helen Hodges ◽  
Jeffrey A. Gray
Keyword(s):  
Latent Inhibition ◽  
Conditioned Suppression ◽  
Opposite Effect ◽  
Partial Support ◽  
Attentional Deficits ◽  
Acute Schizophrenia ◽  
Retarding Effect ◽  
Ru 24969 ◽  
Serotonergic Function

When animals are exposed to a stimulus that has no consequences they are subsequently impaired in learning that this stimulus predicts an important event, such as footshock. This retarding effect of stimulus pre-exposure is called latent inhibition (LI) and is reliably disrupted by amphetamine, antipsychotics having an opposite effect. The present experiments investigated whether agents which affect serotonergic transmission also attenuate LI, using a conditioned suppression of drinking procedure. The results showed that the 5-HT2 antagonist ritanserin (2.0 mg/kg), and the 5-HT1b agonist RU 24969 (0.5 and 10.0 mg/kg) attenuated LI by increasing learning in pre-exposed animals, whilst the effects of the 5-HT1a agonist 8-OH-DPAT (0.38 mg/kg), though in a similar direction, were not significant. These experiments provide partial support for the involvement of serotonin in LI. Since amphetamine-induced attenuation of LI has been proposed as a model for the attentional deficits found in acute schizophrenia, these results are discussed in terms of the possible involvement of reduced serotonergic function in schizophrenic attentional disorder.

Associative learning and latent inhibition in a conditioned suppression paradigm in humans

2000 ◽  
Vol 117 (1-2) ◽  
pp. 53-60 ◽  
Author(s):  
João Vinicius Salgado ◽  
Marc Vidal ◽  
Philippe Oberling ◽  
Frederico Guilherme Graeff ◽  
Jean Marie Danion ◽  
...  
Keyword(s):  
Associative Learning ◽  
Latent Inhibition ◽  
Conditioned Suppression

scholarly journals EMD386088 (5 mg/kg) has no effect on latent inhibition shown to both light and noise stimuli

2019 ◽  
Vol 34 (1) ◽  
pp. 145-147
Author(s):  
Helen Joan Cassaday ◽  
Karen Elizabeth Thur
Keyword(s):  
Fear Conditioning ◽  
Latent Inhibition ◽  
Conditioned Suppression ◽  
Conditioning Procedure ◽  
Conditioned Stimuli ◽  
Receptor Antagonists ◽  
Clinical Model ◽  
Attentional Switching

Activation of 5-hydroxytyptamine6 (5-HT6) receptors stimulates attentional switching and 5-HT6 receptor antagonists are putative drugs for psychosis. Latent inhibition (LI) provides a pre-clinical model of attentional switching and ‘antipsychotic-like’ action and is known to be modulated by 5-hydroxytyptamine. In the present study, LI was shown in a fear conditioning procedure that measured suppression of drinking after conditioning with footshock. In two experiments (each n = 48) it was shown that pre-exposure to both light- and noise-conditioned stimuli reduced conditioned suppression relative to the corresponding non-pre-exposed control. However, counter to prediction, LI was intact after treatment with the 5-HT6 agonist EMD386088 (5 mg/kg).

A Search for Context-Stimulus Associations in Latent Inhibition

1984 ◽  
Vol 36 (2b) ◽  
pp. 145-169 ◽  
Author(s):  
Geoffrey Hall ◽  
Hugh Minor
Keyword(s):  
Latent Inhibition ◽  
Conditioned Suppression ◽  
Contextual Factors ◽  
Repeated Exposure ◽  
Latent Inhibition Effect ◽  
Inhibition Effect ◽  
Context Stimulus ◽  
Exposure Experiment ◽  
Lever Pressing

Six experiments investigated the effects of pre-exposure to a tone on the subsequent acquisition of conditioned suppression by rats. In Experiments 1–3 the response suppressed was drinking; in Experiments 4–6 it was food-rewarded lever pressing. Repeated exposure to the tone resulted in latent inhibition, i.e., a retardation in the acquisition of suppression. The size of the latent inhibition effect was reduced when a different context was used for conditioning from that used for pre-exposure (Experiment 2). When the context remained the same throughout, a phase of exposure to the context alone, interposed between pre-exposure and conditioning, had no influence on the size of the latent inhibition effect ultimately observed. This last result casts doubt upon Wagner's (1976, 1979) theory of the role of contextual factors in latent inhibition, and alternative accounts are considered.

Early handling and latent inhibition in the conditioned suppression paradigm

1987 ◽  
Vol 20 (2) ◽  
pp. 233-240 ◽  
Author(s):  
I. Weiner ◽  
J. Feldon ◽  
D. Ziv-Harris
Keyword(s):  
Latent Inhibition ◽  
Conditioned Suppression ◽  
Early Handling

Reduction of latent inhibition by d-amphetamine in a conditioned suppression paradigm in humans

2000 ◽  
Vol 117 (1-2) ◽  
pp. 61-67 ◽  
Author(s):  
João Vinicius Salgado ◽  
Luiz Alberto Hetem ◽  
Marc Vidal ◽  
Frederico Guilherme Graeff ◽  
Jean Marie Danion ◽  
...  
Keyword(s):  
Latent Inhibition ◽  
Conditioned Suppression
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